51 research outputs found
Citizen Science in Archaeology : Developing a Collaborative Web Service for Archaeological Finds in Finland
Peer reviewe
The usage of computer-aided cooling curve thermal analysis to optimise eutectic refiner and modifier in Al-Si alloys
Bismuth, antimony and strontium concentrations were optimised to alter the eutectic Al-Si phase in a commercial Al-Si-Cu-Mg alloy by way of computer-aided cooling curve thermal analysis. The results show that the eutectic growth temperature shifted to lower temperatures for all three inoculants. However, addition of Sr resulted in more depression of growth temperature compared with Bi and Sb. No further significant changes were observed with increasing the concentrations to more than 1, 0.5 and 0.04 wt% of Bi, Sb and Sr, respectively. The recalescence of these concentrations, meanwhile, showed a significant increase of magnitude. A good correlation was found between the results of thermal and microstructural analysis. For Bi and Sb, the eutectic depression temperature can be used as an individual criterion to gauge optimal levels of content in the refinement of Si, whereas for Sr, both depression temperature and recalescence magnitude must be considered. Based on the observed depression in eutectic growth temperature and recalescence, it can be concluded that the optimal concentrations to refine the eutectic Al-Si phase with Bi and Sb and to modify it with Sr at the given solidification conditions were 1, 0.5 and 0.04 wt%, respectively
Case report: chemotherapy in conjunction with bloodâbrain barrier disruption for a patient with germ cell tumor with multiple brain metastases
Clinical practice points
Testicular cancer with brain metastases is related to poor prognosis because the penetration of chemotherapeutic agents is decreased by the bloodâbrain barrier.
The standard treatment of brain metastasesâwhole brain radiation therapy combined with chemotherapyâis related to a limited increase in survival and considerable deleterious cognitive effects.
The bloodâbrain barrier can be transiently disrupted using hyperosmolar intra-arterial mannitol injection. When combined with intra-arterial chemotherapy, therapeutic intratumoral concentrations can be attained.
In experienced centers, bloodâbrain barrier disruption therapy is relatively safe with a low incidence of catheter-related complications.
Bloodâbrain barrier disruption therapy is a promising treatment modality for brain metastases as an alternative to whole brain radiation therapy
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