Intermediate inflation and the slow-roll approximation

It is shown that spatially homogeneous solutions of the Einstein equations coupled to a nonlinear scalar field and other matter exhibit accelerated expansion at late times for a wide variety of potentials $V$. These potentials are strictly positive but tend to zero at infinity. They satisfy restrictions on $V'/V$ and $V''/V'$ related to the slow-roll approximation. These results generalize Wald's theorem for spacetimes with positive cosmological constant to those with accelerated expansion driven by potentials belonging to a large class.Comment: 19 pages, results unchanged, additional backgroun

{\it Ab initio} calculations of magnetic structure and lattice dynamics of Fe/Pt multilayers

The magnetization distribution, its energetic characterization by the interlayer coupling constants and lattice dynamics of (001)-oriented Fe/Pt multilayers are investigated using density functional theory combined with the direct method to determine phonon frequencies. It is found that ferromagnetic order between consecutive Fe layers is favoured, with the enhanced magnetic moments at the interface. The bilinear and biquadratic coupling coefficients between Fe layers are shown to saturate fast with increasing thickness of nonmagnetic Pt layers which separate them. The phonon calculations demonstrate a rather strong dependence of partial iron phonon densities of states on the actual position of Fe monolayer in the multilayer structure.Comment: 7 pages, 8 figure

Magnetic and Structural Studies of the Quasi-Two-Dimensional Spin-Gap System (CuCl)LaNb2O7

We report magnetization, nuclear magnetic resonance (NMR), nuclear quadrupole resonance (NQR), and transmission electron microscopy (TEM) studies on the quasi-two-dimensional spin-gap system (CuCl)LaNb2O7, a possible candidate for the J1-J2 model on a square lattice. A sharp single NQR line is observed at the Cu and Cl sites, indicating that both Cu and Cl atoms occupy a unique site. However, the electric field gradient tensors at the Cu, Cl, and La sites do not have axial symmetry. This is incompatible with the reported crystal structure. Thus the J1-J2 model has to be modified. We propose alternative two-dimensional dimer models based on the NMR, NQR, and TEM results. The value of the hyperfine coupling constant at the Cu sites indicates that the spin density is mainly on the d(3z2-r2) orbital (z parallel c). At 1.5 K, Cu- and Nb-NMR signals disappear above the critical field Bc1 = 10.3 T determined from the onset of the magnetization, indicating a field-induced magnetic phase transition at Bc1.Comment: 9 pages, 16 figure

Can Gravitational Waves Prevent Inflation?

To investigate the cosmic no hair conjecture, we analyze numerically 1-dimensional plane symmetrical inhomogeneities due to gravitational waves in vacuum spacetimes with a positive cosmological constant. Assuming periodic gravitational pulse waves initially, we study the time evolution of those waves and the nature of their collisions. As measures of inhomogeneity on each hypersurface, we use the 3-dimensional Riemann invariant ${\cal I}\equiv {}~^{(3)\!}R_{ijkl}~^{(3)\!}R^{ijkl}$ and the electric and magnetic parts of the Weyl tensor. We find a temporal growth of the curvature in the waves' collision region, but the overall expansion of the universe later overcomes this effect. No singularity appears and the result is a ``no hair" de Sitter spacetime. The waves we study have amplitudes between $0.020\Lambda \leq {\cal I}^{1/2} \leq 125.0\Lambda$ and widths between $0.080l_H \leq l \leq 2.5l_H$, where $l_H=(\Lambda/3)^{-1/2}$, the horizon scale of de Sitter spacetime. This supports the cosmic no hair conjecture.Comment: LaTeX, 11 pages, 3 figures are available on request <To [email protected] (Hisa-aki SHINKAI)>, WU-AP/29/9

Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells

Purpose: Chronic lymphocytic leukemia (CLL) is currently incurable with standard chemotherapeutic agents, highlighting the need for novel therapies. Overcoming proliferative and cytoprotective signals generated within the microenvironment of lymphoid organs is essential for limiting CLL progression and ultimately developing a cure. Experimental Design: We assessed the potency of cyclin-dependent kinase (CDK) inhibitor CR8, a roscovitine analog, to induce apoptosis in primary CLL from distinct prognostic subsets using flow cytometry–based assays. CLL cells were cultured in in vitro prosurvival and proproliferative conditions to mimic microenvironmental signals in the lymphoid organs, to elucidate the mechanism of action of CR8 in quiescent and proliferating CLL cells using flow cytometry, Western blotting, and quantitative real-time PCR. Results: CR8 was 100-fold more potent at inducing apoptosis in primary CLL cells than roscovitine, both in isolated culture and stromal-coculture conditions. Importantly, CR8 induced apoptosis in CD40-ligated CLL cells and preferentially targeted actively proliferating cells within these cultures. CR8 treatment induced downregulation of the antiapoptotic proteins Mcl-1 and XIAP, through inhibition of RNA polymerase II, and inhibition of NF-κB signaling at the transcriptional level and through inhibition of the inhibitor of IκB kinase (IKK) complex, resulting in stabilization of IκBα expression. Conclusions: CR8 is a potent CDK inhibitor that subverts pivotal prosurvival and proproliferative signals present in the tumor microenvironment of CLL patient lymphoid organs. Our data support the clinical development of selective CDK inhibitors as novel therapies for CLL

Energy Density of Non-Minimally Coupled Scalar Field Cosmologies

Scalar fields coupled to gravity via $\xi R {\Phi}^2$ in arbitrary Friedmann-Robertson-Walker backgrounds can be represented by an effective flat space field theory. We derive an expression for the scalar energy density where the effective scalar mass becomes an explicit function of $\xi$ and the scale factor. The scalar quartic self-coupling gets shifted and can vanish for a particular choice of $\xi$. Gravitationally induced symmetry breaking and de-stabilization are possible in this theory.Comment: 18 pages in standard Late

Bianchi type IX asymptotical behaviours with a massive scalar field: chaos strikes back

We use numerical integrations to study the asymptotical behaviour of a homogeneous but anisotropic Bianchi type IX model in General Relativity with a massive scalar field. As it is well known, for a Brans-Dicke theory, the asymptotical behaviour of the metric functions is ruled only by the Brans-Dicke coupling constant with respect to the value -3/2. In this paper we examine if such a condition still exists with a massive scalar field. We also show that, contrary to what occurs for a massless scalar field, the singularity oscillatory approach may exist in presence of a massive scalar field having a positive energy density.Comment: 31 pages, 7 figures (low resolution

Accelerated cosmological expansion due to a scalar field whose potential has a positive lower bound

In many cases a nonlinear scalar field with potential $V$ can lead to accelerated expansion in cosmological models. This paper contains mathematical results on this subject for homogeneous spacetimes. It is shown that, under the assumption that $V$ has a strictly positive minimum, Wald's theorem on spacetimes with positive cosmological constant can be generalized to a wide class of potentials. In some cases detailed information on late-time asymptotics is obtained. Results on the behaviour in the past time direction are also presented.Comment: 16 page

Inverse Scattering at a Fixed Quasi-Energy for Potentials Periodic in Time

We prove that the scattering matrix at a fixed quasi--energy determines uniquely a time--periodic potential that decays exponentially at infinity. We consider potentials that for each fixed time belong to $L^{3/2}$ in space. The exponent 3/2 is critical for the singularities of the potential in space. For this singular class of potentials the result is new even in the time--independent case, where it was only known for bounded exponentially decreasing potentials.Comment: In this revised version I give a more detailed motivation of the class of potentials that I consider and I have corrected some typo