2,209 research outputs found
Veränderungen im Bildaufbau in der Steigbildmethode durch die Alterung von Milch
The Uni Kassel, FG bio-dynamic agriculture, wants to use the capillary dynamolysis
according to Wala (Steigbildethode) for milk samples from different collection-days.
Based on former methodological investigation (Zalecka 2006) the aim of the study is
to show the aging effect and to test, whether a once taken sample represents the
farm. Result: the repeatedly taken samples seem to be equal, but variation in the
climatic conditions of the chamber as well as aging of the solution have a tremendous
influence on the pictures and must be standardised
ShapeFit and ShapeKick for Robust, Scalable Structure from Motion
We introduce a new method for location recovery from pair-wise directions
that leverages an efficient convex program that comes with exact recovery
guarantees, even in the presence of adversarial outliers. When pairwise
directions represent scaled relative positions between pairs of views
(estimated for instance with epipolar geometry) our method can be used for
location recovery, that is the determination of relative pose up to a single
unknown scale. For this task, our method yields performance comparable to the
state-of-the-art with an order of magnitude speed-up. Our proposed numerical
framework is flexible in that it accommodates other approaches to location
recovery and can be used to speed up other methods. These properties are
demonstrated by extensively testing against state-of-the-art methods for
location recovery on 13 large, irregular collections of images of real scenes
in addition to simulated data with ground truth
Dynamical and quasistatic structural relaxation paths in Pd_(40)Ni_(40)P_(20) glass
By sequential heat treatment of a Pd_(40)Ni_(40)P_(20) metallic glass at temperatures and durations for which
α-relaxation is not possible, dynamic, and quasistatic relaxation paths below the glass transition are
identified via ex situ ultrasonic measurements following each heat treatment. The dynamic
relaxation paths are associated with hopping between nonequilibrium potential energy states of the
glass, while the quasistatic relaxation path is associated with reversible β-relaxation events toward
quasiequilibrium states. These quasiequilibrium states are identified with secondary potential energy
minima that exist within the inherent energy minimum of the glass, thereby supporting the concept
of the sub-basin/metabasin organization of the potential-energy landscape
Optimized random phase approximations for arbitrary reference systems: extremum conditions and thermodynamic consistence
The optimized random phase approximation (ORPA) for classical liquids is
re-examined in the framework of the generating functional approach to the
integral equations. We show that the two main variants of the approximation
correspond to the addition of the same correction to two different first order
approximations of the homogeneous liquid free energy. Furthermore, we show that
it is possible to consistently use the ORPA with arbitrary reference systems
described by continuous potentials and that the same approximation is
equivalent to a particular extremum condition for the corresponding generating
functional. Finally, it is possible to enforce the thermodynamic consistence
between the thermal and the virial route to the equation of state by requiring
the global extremum condition on the generating functional.Comment: 8 pages, RevTe
Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma
<p>Abstract</p> <p>Background</p> <p>The proteasome inhibitor bortezomib can inhibit activation of the transcription factor NF-κB, a mechanism implicated in its anti-neoplastic effects observed in mantle cell lymphoma (MCL). However, NF-κB can be activated through many distinct mechanisms, including proteasome independent pathways. While MCL cells have been shown to harbor constitutive NF-κB activity, what fraction of this activity in primary MCL samples is sensitive or resistant to inhibition by bortezomib remains unclear.</p> <p>Results</p> <p>Proteasome activity in the EBV-negative MCL cell lines Jeko-1 and Rec-1 is inhibited by greater than 80% after exposure to 20 nM bortezomib for 4 hours. This treatment decreased NF-κB activity in Jeko-1 cells, but failed to do so in Rec-1 cells when assessed by electrophoretic mobility shift assay (EMSA). Concurrently, Rec-1 cells were more resistant to the cytotoxic effects of bortezomib than Jeko-1 cells. Consistent with a proteasome inhibitor resistant pathway of activation described in mouse B-lymphoma cells (WEHI231) and a breast carcinoma cell line (MDA-MB-468), the bortezomib-resistant NF-κB activity in Rec-1 cells is inhibited by calcium chelators, calmodulin inhibitors, and perillyl alcohol, a monoterpene capable of blocking L-type calcium channels. Importantly, the combination of perillyl alcohol and bortezomib is synergistic in eliciting Rec-1 cell cytotoxicity. The relevance of these results is illuminated by the additional finding that a considerable fraction of primary MCL samples (8 out of 10) displayed bortezomib-resistant constitutive NF-κB activity.</p> <p>Conclusion</p> <p>Our findings show that bortezomib-resistant NF-κB activity is frequently observed in MCL samples and suggest that this activity may be relevant to MCL biology as well as serve as a potential therapeutic target.</p
Dynamics in binary cluster crystals
As a result of the application of coarse-graining procedures to describe
complex fluids, the study of systems consisting of particles interacting
through bounded, repulsive pair potentials has become of increasing interest in
the last years. A well known example is the so-called Generalized Exponential
Model (GEM-), for which the interaction between particles is described by
the potential . Interactions with
lead to the formation of a novel phase of soft matter consisting of cluster
crystals. Recent studies on the phase behavior of binary mixtures of GEM-
particles have provided evidence for the formation of novel kinds of alloys,
depending on the cross interactions between the two species. This work aims to
study the dynamic behavior of such binary mixtures by means of extensive
molecular dynamics simulations, and in particular to investigate the effect of
the addition of non-clustering particles on the dynamic scenario of
one-component cluster crystals. Analogies and differences with the
one-component case are revealed and discussed by analyzing self- and collective
dynamic correlators.Comment: 17 pages, 8 figures, submitted to JSTA
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