Performance of a wireless telemedicine system in a hospital accident and emergency department

The article version is the pre-edited accepted version of the paper which is entitled: Performance of a wireless telemedicine system: MedLANThis paper validates a medical videoconferencing system previously developed, called MedLAN. Besides the positive comments that medical consultants might have regarding a wireless videoconferencing system designed for use inside the A&E wards, a methodically and exhaustive clinical testing of such a system must take place before adopting such technology in a wider scale. Clinical testing using a wide number of patients, modalities and a number of medical consultants proved that the suggested system could operate effectively under most conditions and it would be beneficiary to the patients. After this clinical evaluation, a number of hospitals showed interest on installing such a system in their A&E wards

The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes.

Phagosomes were purified from human neutrophils ingesting Salmonella typhimurium opsonized with adsorbed normal human serum or with rabbit IgG. Constituents within the phagosome were endogenously labeled by supplying the cells with 125INa during phagocytosis. Lactoferrin and vitamin B12 binding protein (TC1 and TC3), markers for specific granules, were present in the phagosomes from neutrophils ingesting S. typhimurium opsonized with IgG but were 3.5- to 5-fold less prominent in phagosomes from cells phagocytosing Salmonella bearing C3 fragments only. In contrast, iodinated azurophilic granule components, most prominently defensins, were the major constituents in phagosomes prepared under both opsonization conditions. Furthermore, labeled complement (CR1 and CR3) and immunoglobulin (Fc gamma RIII) receptors were incorporated in the phagosome regardless of the ligand mediating phagocytosis. These results suggest that the ligand-receptor interactions mediating phagocytosis influence incorporation of neutrophil-specific granule contents into phagosomes

On a theoretical model for d-wave to mixed s- and d-wave transition in cuprate superconductors

A U(3) model proposed by Iachello for superconductivity in cuprate materials is analyzed. The model consists of s and d pairs (approximated as bosons) in a two-dimensional Fermi system with a surface. The transition occurs between a phase in which the system is a condensate of one of the bosons, and a phase which is a mixture of two types of bosons. In the current work we have investigated the validity of the Bogoliubov approximation, and we used a reduced Hamiltonian to determine a phase diagram, the symmetry of the phases and the temperature dependence of the heat capacity.Comment: 8 pages, 4 figure

Generating optimized Fourier interpolation routines for density function theory using SPIRAL

© 2015 IEEE.Upsampling of a multi-dimensional data-set is an operation with wide application in image processing and quantum mechanical calculations using density functional theory. For small up sampling factors as seen in the quantum chemistry code ONETEP, a time-shift based implementation that shifts samples by a fraction of the original grid spacing to fill in the intermediate values using a frequency domain Fourier property can be a good choice. Readily available highly optimized multidimensional FFT implementations are leveraged at the expense of extra passes through the entire working set. In this paper we present an optimized variant of the time-shift based up sampling. Since ONETEP handles threading, we address the memory hierarchy and SIMD vectorization, and focus on problem dimensions relevant for ONETEP. We present a formalization of this operation within the SPIRAL framework and demonstrate auto-generated and auto-tuned interpolation libraries. We compare the performance of our generated code against the previous best implementations using highly optimized FFT libraries (FFTW and MKL). We demonstrate speed-ups in isolation averaging 3x and within ONETEP of up to 15%

Service evaluation to establish the sensitivity, specificity and additional value of broad-range 16S rDNA PCR for the diagnosis of infective endocarditis from resected endocardial material in patients from eight UK and Ireland hospitals

Infective endocarditis (IE) can be diagnosed in the clinical microbiology laboratory by culturing explanted heart valve material. We present a service evaluation that examines the sensitivity and specificity of a broad-range 16S rDNA polymerase chain reaction (PCR) assay for the detection of the causative microbe in culture-proven and culture-negative cases of IE. A clinical case-note review was performed for 151 patients, from eight UK and Ireland hospitals, whose endocardial specimens were referred to the Microbiology Laboratory at Great Ormond Street Hospital (GOSH) for broad-range 16S rDNA PCR over a 12-year period. PCR detects the causative microbe in 35/47 cases of culture-proven IE and provides an aetiological agent in 43/69 cases of culture-negative IE. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the 16S rDNA PCR assay were calculated for this series of selected samples using the clinical diagnosis of IE as the reference standard. The values obtained are as follows: sensitivity = 67 %, specificity = 91 %, PPV = 96 % and NPV = 46 %. A wide range of organisms are detected by PCR, with Streptococcus spp. detected most frequently and a relatively large number of cases of Bartonella spp. and Tropheryma whipplei IE. PCR testing of explanted heart valves is recommended in addition to culture techniques to increase diagnostic yield. The data describing the aetiological agents in a large UK and Ireland series of culture-negative IE will allow future development of the diagnostic algorithm to include real-time PCR assays targeted at specific organisms

Phase Diagram of the Holstein-Hubbard Two-Leg Ladder

Using a functional renormalization group method, we obtain the phase diagram of the two-leg ladder system within the Holstein-Hubbard model, which includes both electron-electron and electron-phonon interactions. Our renormalization group technique allows us to analyze the problem for both weak and strong electron-phonon coupling. We show that, in contrast results from conventional weak coupling studies, electron-phonon interactions can dominate electron-electron interactions because of retardation effects.Comment: 4 page