Effectiveness of the combination elvitegravir/cobicistat/tenofovir/emtricitabine (EVG/COB/TFV/FTC) plus darunavir among treatment-experienced patients in clinical practice : A multicentre cohort study

Background: The aim of this study was to investigate the effectiveness and tolerability of the combination elvitegravir/cobicistat/tenofovir/emtricitabine plus darunavir (EVG/COB/TFV/FTC + DRV) in treatment-experienced patients from the cohort of the Spanish HIV/AIDS Research Network (CoRIS). Methods: Treatment-experienced patients starting treatment with EVG/COB/TFV/FTC + DRV during the years 2014-2018 and with more than 24 weeks of follow-up were included. TFV could be administered either as tenofovir disoproxil fumarate or tenofovir alafenamide. We evaluated virological response, defined as viral load (VL) < 50 copies/ml and < 200 copies/ml at 24 and 48 weeks after starting this regimen, stratified by baseline VL (< 50 or ≥ 50 copies/ml at the start of the regimen). Results: We included 39 patients (12.8% women). At baseline, 10 (25.6%) patients had VL < 50 copies/ml and 29 (74.4%) had ≥ 50 copies/ml. Among patients with baseline VL < 50 copies/ml, 85.7% and 80.0% had VL < 50 copies/ml at 24 and 48 weeks, respectively, and 100% had VL < 200 copies/ml at 24 and 48 weeks. Among patients with baseline VL ≥ 50 copies/ml, 42.3% and 40.9% had VL < 50 copies/ml and 69.2% and 68.2% had VL < 200 copies/ml at 24 and 48 weeks. During the first 48 weeks, no patients changed their treatment due to toxicity, and 4 patients (all with baseline VL ≥ 50 copies/ml) changed due to virological failure. Conclusions: EVG/COB/TFV/FTC + DRV was well tolerated and effective in treatment-experienced patients with undetectable viral load as a simplification strategy, allowing once-daily, two-pill regimen with three antiretroviral drug classes. Effectiveness was low in patients with detectable viral loads

Tropical Ungulates of Argentina

Argentina has an extensive and diverse terrain classified into 11 ecoregions. Seven of these ecoregions, occupying the north and north-central parts of the country, house the 11 tropical ungulate species found here. The ecoregions are lowland and subtropical, some beginning in the tropics, some extending to temperate climates. The principal topographical characteristics, hydrology, climate, vegetation and fauna are described for these seven ecoregions. Each of the 11 species is then treated in detail with respect to its ecology and conservation. Emphasis is placed on distribution, habitat and density, feeding ecology, threats and conservation in Argentina, based on the most recent studies. Data on reproductive biology and behaviour are included where information is relatively recent and unlikely to be covered elsewhere. The species include the following: the Brazilian tapir (Tapirus terrestris), found in northern subtropical ecoregions, three species of peccary (Tayassu pecari, Pecari tajacu and Parachoerus wagneri) from northern subtropical and drier regions, of which the Chacoan peccary (P. wagneri) is endemic while the other two species have more extensive distributions. The guanaco (Lama guanicoe) occurs only in relict populations in the ecoregions considered. The taruca (Hippocamelus antisensis) occupies the eastern boundary between the Yungas and drier, high altitude ecoregions. Three species of brocket deer (Mazama americana, M. gouazoubira and M. nana) occupy the northern tropical, subtropical and Chacoan areas. The marsh deer (Blastocerus dichotomus), the largest South American deer, has small populations occupying wetlands from the northern border to the Parana delta, while the pampas deer (Ozotocerus bezoaticus) is found in four isolated populations from Ibera to Buenos Aires province. Argentina represents the southern limit to the distribution of all these species and thus threats are often magnified. Ongoing conservation activities include the maintenance of protected areas, promotion (difusion, education, sensitization), investigation and the reintroduction of some species of formerly extinct ungulates into the Ibera wetlands area.Fil: Black Decima, Patricia. Universidad Nacional de Tucumán; ArgentinaFil: Camino, Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Centro de Ecología Aplicada del Litoral. Universidad Nacional del Nordeste. Centro de Ecología Aplicada del Litoral; ArgentinaFil: Cirignoli, Sebastian. Centro de Investigaciones del Bosque Atlántico; ArgentinaFil: de Bustos, Soledad. Fundación Biodiversidad; ArgentinaFil: Matteucci, Silvia Diana. Universidad de Buenos Aires. Facultad de Arquitectura y Urbanismo. Grupo de Ecología del Paisaje y Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perez Carusi, Lorena Cynthia. Administración de Parques Nacionales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Varela, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; Argentina. Centro de Investigaciones del Bosque Atlántico; Argentin