6,216 research outputs found
Unpacking the difference between digital transformation and IT-enabled organizational transformation
Although digital transformation offers a number of opportunities for today’s organizations, information systems scholars and practitioners struggle to grasp what digital transformation really is, particularly in terms of how it differs from the well-established concept of information technology (IT)-enabled organizational transformation. By integrating literature from organization science and information systems research with two longitudinal case studies—one on digital transformation, the other on IT-enabled organizational transformation—we develop an empirically grounded conceptualization that sets these two phenomena apart. We find that there are two distinctive differences: (1) digital transformation activities leverage digital technology in (re)defining an organization’s value proposition, while IT-enabled organizational transformation activities leverage digital technology in supporting the value proposition, and (2) digital transformation involves the emergence of a new organizational identity, whereas IT-enabled organizational transformation involves the enhancement of an existing organizational identity. We synthesize these arguments in a process model to distinguish the different types of transformations and propose directions for future research
Ascorbate depletion increases growth and metastasis of melanoma cells in vitamin C deficient mice
Aim: Our main objective was to determine the effect of ascorbate supplementation in mice unable to synthesize ascorbic acid (gulo KO) when challenged with murine B16FO cancer cells. Methods: Gulo KO female mice 36–40 weeks of age were deprived of or maintained on ascorbate in food and water for 4 weeks prior to subcutaneous injection of 2.5×106 B16FO murine melanoma cells in the right flank of mice. A control group of wild type mice were also injected with the melanoma cells and maintained on a regular murine diet. Mice were continued on their respective diets for another 2 weeks after injection. The mice were then sacrificed, blood was drawn and their tumors were measured, excised and processed for histology. Results: Mean weight of animals decreased significantly (30%, p < 0.0001) in the ascorbate-restricted group but increased slightly, but insignificantly, in the ascorbate-supplemented group. The mean tumor weight in ascorbate supplemented mice was significantly reduced (by 64%, p = 0.004) compared to tumor weight in ascorbate-deprived gulo mice. The mean tumor weight of wild type mice did not differ significantly from the ascorbate-supplemented mice. Gulo KO mice supplemented with ascorbate developed smaller tumors with more collagen encapsulation and fibrous capsule interdigitation, while gulo KO mice deprived of ascorbate hosted large tumors with poorly defined borders, showing more necrosis and mitosis. Ascorbate supplementation of gulo KO mice resulted in profoundly decreased serum inflammatory cytokine IL-6 (90% decrease, p = 0.04) and IL-1β (62% decrease) compared to the levels in gulo KO mice deprived of ascorbate. Conclusion: Ascorbate supplementation modulated tumor growth and inflammatory cytokine secretion as well as enhanced encapsulation of tumors in scorbutic mice
Phase Transitions in the Two-Dimensional XY Model with Random Phases: a Monte Carlo Study
We study the two-dimensional XY model with quenched random phases by Monte
Carlo simulation and finite-size scaling analysis. We determine the phase
diagram of the model and study its critical behavior as a function of disorder
and temperature. If the strength of the randomness is less than a critical
value, , the system has a Kosterlitz-Thouless (KT) phase transition
from the paramagnetic phase to a state with quasi-long-range order. Our data
suggest that the latter exists down to T=0 in contradiction with theories that
predict the appearance of a low-temperature reentrant phase. At the critical
disorder and for there is no
quasi-ordered phase. At zero temperature there is a phase transition between
two different glassy states at . The functional dependence of the
correlation length on suggests that this transition corresponds to the
disorder-driven unbinding of vortex pairs.Comment: LaTex file and 18 figure
An implicit method for radiative transfer with the diffusion approximation in SPH
An implicit method for radiative transfer in SPH is described. The diffusion
approximation is used, and the hydrodynamic calculations are performed by a
fully three--dimensional SPH code. Instead of the energy equation of state for
an ideal gas, various energy states and the dissociation of hydrogen molecules
are considered in the energy calculation for a more realistic temperature and
pressure determination. In order to test the implicit code, we have performed
non--isothermal collapse simulations of a centrally condensed cloud, and have
compared our results with those of finite difference calculations performed by
MB93. The results produced by the two completely different numerical methods
agree well with each other.Comment: 25 pages, 9 figure
Moving Wigner Glasses and Smectics: Dynamics of Disordered Wigner Crystals
We examine the dynamics of driven classical Wigner solids interacting with
quenched disorder from charged impurities. For strong disorder, the initial
motion is plastic -- in the form of crossing winding channels. For increasing
drive, the disordered Wigner glass can reorder to a moving Wigner smectic --
with the electrons moving in non-crossing 1D channels. These different dynamic
phases can be related to the conduction noise and I(V) curves. For strong
disorder, we show criticality in the voltage onset just above depinning. We
also obtain the dynamic phase diagram for driven Wigner solids and prove that
there is a finite threshold for transverse sliding, recently found
experimentally.Comment: 4 pages, 4 postscript figure
Domain regime in two-dimensional disordered vortex matter
A detailed numerical study of the real space configuration of vortices in
disordered superconductors using 2D London-Langevin model is presented. The
magnetic field is varied between 0 and for various pinning
strengths . For weak pinning, an inhomogeneous disordered vortex matter
is observed, in which the topologically ordered vortex lattice survives in
large domains. The majority of the dislocations in this state are confined to
the grain boundaries/domain walls. Such quasi-ordered configurations are
observed in the intermediate fields, and we refer it as the domain regime (DR).
The DR is distinct from the low-field and the high-fields amorphous regimes
which are characterized by a homogeneous distribution of defects over the
entire system. Analysis of the real space configuration suggests domain wall
roughening as a possible mechanism for the crossover from the DR to the
high-field amorphous regime. The DR also shows a sharp crossover to the high
temperature vortex liquid phase. The domain size distribution and the roughness
exponent of the lattice in the DR are also calculated. The results are compared
with some of the recent Bitter decoration experiments.Comment: 9 pages, 9 figure
Phase diagram of a Disordered Boson Hubbard Model in Two Dimensions
We study the zero-temperature phase transition of a two-dimensional
disordered boson Hubbard model. The phase diagram of this model is constructed
in terms of the disorder strength and the chemical potential. Via quantum Monte
Carlo simulations, we find a multicritical line separating the weak-disorder
regime, where a random potential is irrelevant, from the strong-disorder
regime. In the weak-disorder regime, the Mott-insulator-to-superfluid
transition occurs, while, in the strong-disorder regime, the
Bose-glass-to-superfluid transition occurs. On the multicritical line, the
insulator-to-superfluid transition has the dynamical critical exponent and the correlation length critical exponent ,
that are different from the values for the transitions off the line. We suggest
that the proliferation of the particle-hole pairs screens out the weak disorder
effects.Comment: 4 pages, 4 figures, to be published in PR
Wafer-scale fabrication of 2D nanostructures via thermomechanical nanomolding
With shrinking dimensions in integrated circuits, sensors, and functional
devices, there is a pressing need to develop nanofabrication techniques with
simultaneous control of morphology, microstructure, and material composition
over wafer length scales. Current techniques are largely unable to meet all
these conditions, suffering from poor control of morphology and defect
structure or requiring extensive optimization or post-processing to achieve
desired nanostructures. Recently, thermomechanical nanomolding (TMNM) has been
shown to yield single-crystalline, high aspect ratio nanowires of metals,
alloys, and intermetallics over wafer-scale distances. Here, we extend TMNM for
wafer-scale fabrication of 2D nanostructures. Using Cu, we successfully
nanomold Cu nanoribbons with widths < 50 nm, depths ~ 0.5-1 microns and lengths
~ 7 mm into Si trenches at conditions compatible with back end of line
processing. Through SEM cross-section imaging and 4D-STEM grain orientation
maps, we show that the grain size of the bulk feedstock is transferred to the
nanomolded structures up to and including single crystal Cu. Based on the
retained microstructures of molded 2D Cu, we discuss the deformation mechanism
during molding for 2D TMNM.Comment: 4 figure
Deformation and Depinning of Superconducting Vortices from Artificial Defects: A Ginzburg-Landau Study
Using Ginzburg-Landau theory, we have performed detailed studies of vortices
in the presence of artificial defect arrays, for a thin film geometry. We show
that when a vortex approaches the vicinity of a defect, an abrupt transition
occurs in which the vortex core develops a ``string'' extending to the defect
boundary, while simultaneously the supercurrents and associated magnetic flux
spread out and engulf the defect. Current induced depinning of vortices is
shown to be dominated by the core string distortion in typical experimental
situations. Experimental consequences of this unusual depinning behavior are
discussed.Comment: 10 pages,9 figure
Synthesis, Characterisation and 3D Printing of an Isosorbide Based, Light Curable, Degradable Polymer for Potential Application in Maxillofacial Reconstruction
Although emergence of bone tissue engineering techniques has revolutionised the field of maxillofacial reconstruction, the successful translation of such products, especially concerning larger sized defects, still remains a significant challenge. Light curable methacrylate based polymers have ideal properties for bone repair. These materials are also suitable for 3D printing which can be applicable for restoration of both function and aesthetics. The main objective of this research was to synthesise a mechanically stable and biologically functional polymer for reconstruction of complex craniofacial defects. The experimental work initially involved synthesis of (((3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diyl)bis(oxy))bis(ethane-2,1-diyl) bis((4-methyl-3-oxopent-4-en-1-yl)carbamate), CSMA-1, and ((((((((((((3R,3aR,6S,6aR)-hexahydrofuro[3,2-b]furan-3,6-diyl)bis(oxy))bis(ethane-2,1 diyl))bis(oxy))bis(carbonyl))bis(azanediyl))bis(methylene))bis(3,3,5-trimethylcyclohexane-5,1-diyl))bis(azanediyl))bis(carbonyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate), CSMA-2; Nuclear Magnetic Resonance (NMR) analysis confirmed formation of the monomers and composite samples were fabricated respectively by exposing 11 mm diameter discs to blue light. Modulus of the tensile elasticity was tested using a biaxial flexural test and the values were found to be between 1 and 3 GPa in CMA-1, CSMA-2 and their composites. In vitro cell culture, using human Bone Marrow Derived Mesenchymal Stem Cells (BMSCs), confirmed non-toxicity of the samples and finally 3D printing allowed direct extrusion and setting of the bio ink into a mesh-like construct
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