20 research outputs found
Effective-Range Expansion of the Neutron-Deuteron Scattering Studied by a Quark-Model Nonlocal Gaussian Potential
The S-wave effective range parameters of the neutron-deuteron (nd) scattering
are derived in the Faddeev formalism, using a nonlocal Gaussian potential based
on the quark-model baryon-baryon interaction fss2. The spin-doublet low-energy
eigenphase shift is sufficiently attractive to reproduce predictions by the
AV18 plus Urbana three-nucleon force, yielding the observed value of the
doublet scattering length and the correct differential cross sections below the
deuteron breakup threshold. This conclusion is consistent with the previous
result for the triton binding energy, which is nearly reproduced by fss2
without reinforcing it with the three-nucleon force.Comment: 21 pages, 6 figures and 6 tables, submitted to Prog. Theor. Phy
Aberrant methylation of NPY, PENK, and WIF1 as a promising marker for blood-based diagnosis of colorectal cancer
Restoring interventions: eco-sustainable weed control
The creation and enlargement of ecological networks is paramount to conserve plant biodiversity, to offer refuge to the local fauna and to improve the environment in general. Such networks intend to conserve areas of great natural value, to restore degraded areas and to link them physically through the creation of ecological corridors. The work described was carried out in order to improve and enlarge an ecological corridor within the experimental farm “Mezzi” of CRA-ISP at Casale Monferrato (AL - Italy). One of its bigger problems, weed control, was solved by increasing the planting density, by sowing herbaceous crops and mulching with woody chips
Turning stem cells into retina: possible strategies for the cure of retinal degenerations
Mpox virus infection and drug treatment modelled in human skin organoids
Mpox virus (MPXV) primarily infects human skin to cause lesions. Currently, robust models that recapitulate skin infection by MPXV are lacking. Here we demonstrate that human induced pluripotent stem cell-derived skin organoids are susceptible to MPXV infection and support infectious virus production. Keratinocytes, the predominant cell type of the skin epithelium, effectively support MPXV infection. Using transmission electron microscopy, we visualized the four stages of intracellular virus particle assembly: crescent formation, immature virions, mature virions and wrapped virions. Transcriptional analysis showed that MPXV infection rewires the host transcriptome and triggers abundant expression of viral transcripts. Early treatment with the antiviral drug tecovirimat effectively inhibits infectious virus production and prevents host transcriptome rewiring. Delayed treatment with tecovirimat also inhibits infectious MPXV particle production, albeit to a lesser extent. This study establishes human skin organoids as a robust experimental model for studying MPXV infection, mapping virus–host interactions and testing therapeutics.</p