Regeneratives Heizen und Kuehlen

Ziel des Vorhabens war die Entwicklung und Erprobung von nach regenerativen Gaskreisprozessen arbeitenden, thermisch angetriebenen Waermepumpen zum Heizen von Ein- und Mehrfamilienhaeusern. Der Bericht weist folgende Gliederung auf: -Thermodynamische Grundlage - Stand der Technik - Prozessauslegung - Auslegung der Versuchsmaschine - Versuchsergebnisse - Vergleich mit anderen Heizsystemen. (HW)The objective of the project was to develop and test renewable-energy operated, gas-cycle-process heat pumps with thermal drives for heating single-and multi-family houses. The report comprises the following parts: thermodynamic bases, state of the art, process design, rating of the experimental unit, test results, comparison with other heating systems. (HW)Available from TIB Hannover: F97B1226+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts.

The hormone calcitonin (CT) is primarily known for its pharmacologic action as an inhibitor of bone resorption, yet CT-deficient mice display increased bone formation. These findings raised the question about the underlying cellular and molecular mechanism of CT action. Here we show that either ubiquitous or osteoclast-specific inactivation of the murine CT receptor (CTR) causes increased bone formation. CT negatively regulates the osteoclast expression of Spns2 gene, which encodes a transporter for the signalling lipid sphingosine 1-phosphate (S1P). CTR-deficient mice show increased S1P levels, and their skeletal phenotype is normalized by deletion of the S1P receptor S1P3. Finally, pharmacologic treatment with the nonselective S1P receptor agonist FTY720 causes increased bone formation in wild-type, but not in S1P3-deficient mice. This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo and provides evidence for a pharmacologically exploitable crosstalk between osteoclasts and osteoblasts

Ocenjevanje vplivov predpisov

Regulatorna funkcija države je v zadnjih nekaj desetljetjih postala predmet široke razprave v različnih forumih, pri čemer se je kot eno izmed osrednjih vprašanj izpostavilo vprašanje kakovosti regulacije. Splošno sprejeto stališčeje, da je eden izmed glavnih instrumentov, namenjenih izboljšanju le-te, analiza učinkov predpisov oz. ocenjevanje vplivov predpisov (Regulatory impact Analysis, RIA). V Sloveniji so bili pred kratkim na vladni ravni storjeni prvi konkretni koraki k sistematični uvedbi RIA, katere sestavni del bo tudi vključevanje javnosti. Na ta način bo RIA služila ne samotehničnemu vidiku reguliranja učinkovitosti in uspešnosti, ampak s transparentnostjo in odprtostjo tudi interesnemu vidiku (legitimnosti)