A local landscape in transition between production and consumption: can new management arrangements preserve the local landscape character?

Around towns in the Alentejo region, the landscape is dominated by a characteristic agricultural small scale mosaic. These areas are central in the region landscape character, – even if the large scale latifundia landscape of the extensive silvo-pastoral systems is most commonly associated with the region. In the last two decades, these parcels became extremely attractive for new comers, who settle in the rural context as residents, week-end visitors, being often also lifestyle farmers. The paper presents a case-study landscape, in Montemor-o-Novo, a small town 100 km from Lisbon, highly subject to the pressure for consumption uses, by urban users. The study shows that the new owners, even if they have settled in the area due to the tranquility and social bindings of the rural, end up doing farming, with new or reshaped production objectives, markets and models, but at the same time maintaining the traditional farm systems. Thus, the landscape character is maintained, so far. Nevertheless, the role of these neo-rurals and lifestyle farmers is still an unseen role, both by the agriculture and the planning sectors. And thus the question is, whether the combination of actors and land management drivers will continue maintaining the landscape in the futur

Reflecting on collaborative research into the sustainability of Mediterranean agriculture: A case study using a systematization of experiences approach

This article describes how a research institute went about reviewing the relationship between its members and external research partners in engaging in collaborative research. A systematization of experiences (SE) process was implemented to enable such review and draw implications for the institute’s strategy regarding research into the sustainability of Mediterranean agriculture. The SE exercise included four workshops attended by selected researchers, one questionnaire survey targeting the institute’s research community, and three focus group discussions with external research partners. The rate of participation by researchers decreased during the process; however, those that followed through to the end of the SE exercise found it to be useful in clarifying both individual and institutional perspectives. Further, SE was seen as a vehicle for increasing the level of understanding between researchers and their willingness to engage in collaborative actions. However, the rapid pace of today’s academic world and the dominant mode of evaluating scientific performance were identified as hindering the conditions needed to allow the necessary space and time for reflection and collaborative efforts. Therefore, the results highlight the current tension between the production of scientific knowledge according to existing patterns and the development of socially meaningful research

Mining the Metal-Rich Stars for Planets

We examine the correlation between stellar metallicity and short period planets. It appears that approximately 1% of dwarf stars in the solar neighborhood harbor short-period planets characterized by near-circular orbits and orbital periods P<20 days. However, among the most metal-rich stars (defined as having [Fe/H]>0.2 dex), it appears that the fraction increases to 10%. Using the Hipparcos database and the Hauck & Mermilliod (1998) compilation of Stromgren uvby photometry, we identify a sample of 206 metal-rich stars of spectral type K, G, and F which have an enhanced probability of harboring short-period planets. Many of these stars would be excellent candidates for addition to radial velocity surveys. We have searched the Hipparcos epoch photometry for transiting planets within our 206 star catalog. We find that the quality of the Hipparcos data is not high enough to permit unambiguous transit detections. It is, however, possible to identify candidate transit periods. We then discuss various ramifications of the stellar metallicity - planet connection. First, we show that there is preliminary evidence for increasing metallicity with increasing stellar mass among known planet-bearing stars. This trend can be explained by a scenario in which planet-bearing stars accrete an average of 30 Earth Masses of rocky material after the gaseous protoplanetary disk phase has ended. We present dynamical calculation which suggest that a survey of metallicities of spectroscopic binary stars can be used to understand the root cause of the stellar metallicity - planet connection.Comment: 36 pages, 8 figures, 2 tables, accepted by Astrophysical Journa

Transparency, trust and minimizing burden to increase recruitment and retentio in trials: A systematic review

Objective: To describe patient perspectives on recruitment and retention in clinical trials. Study Design and Setting: Systematic review of qualitative studies that reported the perspective of adult patients with any health condition who accepted or declined to participate in clinical trials. Results: Sixty-three articles involving 1681 adult patients were included. Six themes were identified. Four themes reflected barriers: ambiguity of context and benefit – patients were unaware of the research question and felt pressured in making decisions; lacking awareness of opportunities – some believed health professionals obscured trials opportunities, or felt confused because of language barriers; wary of added burden – patients were without capacity because of sickness or competing priorities; and skepticism, fear and mistrust – patients feared loss of privacy, were suspicious of doctor's motivation, afraid of being a guinea pig, and disengaged from not knowing outcomes. Two themes captured facilitators: building confidence – patients hoped for better treatment, were supported from family members and trusted medical staff; and social gains and belonging to the community – altruism, a sense of belonging and peer encouragement motivated participation in trials. Conclusion: Improving the visibility and transparency of trials, supporting informed decision making, minimizing burden, and ensuring confidence and trust may improve patient participation in trials

New Debris Disks Around Nearby Main Sequence Stars: Impact on The Direct Detection of Planets

Using the MIPS instrument on the Spitzer telescope, we have searched for infrared excesses around a sample of 82 stars, mostly F, G, and K main-sequence field stars, along with a small number of nearby M stars. These stars were selected for their suitability for future observations by a variety of planet-finding techniques. These observations provide information on the asteroidal and cometary material orbiting these stars - data that can be correlated with any planets that may eventually be found. We have found significant excess 70um emission toward 12 stars. Combined with an earlier study, we find an overall 70um excess detection rate of $13 \pm 3$% for mature cool stars. Unlike the trend for planets to be found preferentially toward stars with high metallicity, the incidence of debris disks is uncorrelated with metallicity. By newly identifying 4 of these stars as having weak 24um excesses (fluxes $\sim$10% above the stellar photosphere), we confirm a trend found in earlier studies wherein a weak 24um excess is associated with a strong 70um excess. Interestingly, we find no evidence for debris disks around 23 stars cooler than K1, a result that is bolstered by a lack of excess around any of the 38 K1-M6 stars in 2 companion surveys. One motivation for this study is the fact that strong zodiacal emission can make it hard or impossible to detect planets directly with future observatories like the {\it Terrestrial Planet Finder (TPF)}. The observations reported here exclude a few stars with very high levels of emission, $>$1,000 times the emission of our zodiacal cloud, from direct planet searches. For the remainder of the sample, we set relatively high limits on dust emission from asteroid belt counterparts

The Distance to SN 1999em from the Expanding Photosphere Method

We present optical and IR spectroscopy of the first two months of evolution of the Type II SN 1999em. We combine these data with high-quality optical/IR photometry beginning only three days after shock breakout, in order to study the performance of the ``Expanding Photosphere Method'' (EPM) in the determination of distances. With this purpose we develop a technique to measure accurate photospheric velocities by cross-correlating observed and model spectra. The application of this technique to SN 1999em shows that we can reach an average uncertainty of 11% in velocity from an individual spectrum. Our analysis shows that EPM is quite robust to the effects of dust. In particular, the distances derived from the VI filters change by only 7% when the adopted visual extinction in the host galaxy is varied by 0.45 mag. The superb time sampling of the BVIZJHK light-curves of SN 1999em permits us to study the internal consistency of EPM and test the dilution factors computed from atmosphere models for Type II plateau supernovae. We find that, in the first week since explosion, the EPM distances are up to 50% lower than the average, possibly due the presence of circumstellar material. Over the following 65 days, on the other hand, our tests lend strong credence to the atmosphere models, and confirm previous claims that EPM can produce consistent distances without having to craft specific models to each supernova. This is particularly true for the VI filters which yield distances with an internal consistency of 4%. From the whole set of BVIZJHK photometry, we obtain an average distance of 7.5+/-0.5 Mpc, where the quoted uncertainty (7%) is a conservative estimate of the internal precision of the method obtained from the analysis of the first 70 days of the supernova evolution.Comment: 68 pages, 15 tables, 22 figures, to appear in Ap

Binocular Encoding in the Damselfly Pre-motor Target Tracking System.

Akin to all damselflies, Calopteryx (family Calopterygidae), commonly known as jewel wings or demoiselles, possess dichoptic (separated) eyes with overlapping visual fields of view. In contrast, many dragonfly species possess holoptic (dorsally fused) eyes with limited binocular overlap. We have here compared the neuronal correlates of target tracking between damselfly and dragonfly sister lineages and linked these changes in visual overlap to pre-motor neural adaptations. Although dragonflies attack prey dorsally, we show that demoiselles attack prey frontally. We identify demoiselle target-selective descending neurons (TSDNs) with matching frontal visual receptive fields, anatomically and functionally homologous to the dorsally positioned dragonfly TSDNs. By manipulating visual input using eyepatches and prisms, we show that moving target information at the pre-motor level depends on binocular summation in demoiselles. Consequently, demoiselles encode directional information in a binocularly fused frame of reference such that information of a target moving toward the midline in the left eye is fused with information of the target moving away from the midline in the right eye. This contrasts with dragonfly TSDNs, where receptive fields possess a sharp midline boundary, confining responses to a single visual hemifield in a sagittal frame of reference (i.e., relative to the midline). Our results indicate that, although TSDNs are conserved across Odonata, their neural inputs, and thus the upstream organization of the target tracking system, differ significantly and match divergence in eye design and predatory strategies. VIDEO ABSTRACT

Patient and Caregiver Priorities for Outcomes in CKD: A Multinational Nominal Group Technique Study

RATIONALE & OBJECTIVE: Patients with chronic kidney disease (CKD) are at an increased risk for premature death, cardiovascular disease, and burdensome symptoms that impair quality of life. We aimed to identify patient and caregiver priorities for outcomes in CKD. STUDY DESIGN: Focus groups with nominal group technique. SETTING & PARTICIPANTS: Adult patients with CKD (all stages) and caregivers in the United States, Australia, and United Kingdom. ANALYTICAL APPROACH: Participants identified, ranked, and discussed outcomes that were important during the stages of CKD before kidney replacement therapy. For each outcome, we calculated a mean importance score (scale, 0-1). Qualitative data were analyzed using thematic analysis. RESULTS: 67 (54 patients, 13 caregivers) participated in 10 groups and identified 36 outcomes. The 5 top-ranked outcomes for patients were kidney function (importance score, 0.42), end-stage kidney disease (0.29), fatigue (0.26), mortality (0.25), and life participation (0.20); and for caregivers, the top 5 outcomes were life participation (importance score, 0.38), kidney function (0.37), mortality (0.23), fatigue (0.21), and anxiety (0.20). Blood pressure, cognition, and depression were consistently ranked in the top 10 outcomes across role (patient/caregiver), country, and treatment stage. Five themes were identified: re-evaluating and reframing life, intensified kidney consciousness, battling unrelenting and debilitating burdens, dreading upheaval and constraints, and taboo and unspoken concerns. LIMITATIONS: Only English-speaking participants were included. CONCLUSIONS: Patients and caregivers gave highest priority to kidney function, mortality, fatigue, life participation, anxiety, and depression. Consistent reporting of these outcomes in research may inform shared decision making based on patient and caregiver priorities in CKD

The Use of Anti-VDAC2 Antibody for the Combined Assessment of Human Sperm Acrosome Integrity and Ionophore A23187-Induced Acrosome Reaction

Voltage-dependent anion channel (VDAC) is mainly located in the mitochondrial outer membrane and participates in many biological processes. In mammals, three VDAC subtypes (VDAC1, 2 and 3) have been identified. Although VDAC has been extensively studied in various tissues and cells, there is little knowledge about the distribution and function of VDAC in male mammalian reproductive system. Several studies have demonstrated that VDAC exists in mammalian spermatozoa and is implicated in spermatogenesis, sperm maturation, motility and fertilization. However, there is no knowledge about the respective localization and function of three VDAC subtypes in human spermatozoa. In this study, we focused on the presence of VDAC2 in human spermatozoa and its possible role in the acrosomal integrity and acrosome reaction using specific anti-VDAC2 monoclonal antibody for the first time. The results exhibited that native VDAC2 existed in the membrane components of human spermatozoa. The co-incubation of spermatozoa with anti-VDAC2 antibody did not affect the acrosomal integrity and acrosome reaction, but inhibited ionophore A23187-induced intracellular Ca2+ increase. Our study suggested that VDAC2 was located in the acrosomal membrane or plasma membrane of human spermatozoa, and played putative roles in sperm functions through mediating Ca2+ transmembrane transport

Symptoms predicting remission after divalproex augmentation with olanzapine in partially nonresponsive patients experiencing mixed bipolar I episode: a post-hoc analysis of a randomized controlled study

<p>Abstract</p> <p>Background</p> <p>Rating scale items in a 6-week clinical trial of olanzapine versus placebo augmentation in patients with mixed bipolar disorder partially nonresponsive to ≥14 days of divalproex monotherapy were analyzed to characterize symptom patterns that could predict remission. At baseline, the two treatment groups were similar.</p> <p>Findings</p> <p>Factor analysis with Varimax rotation was performed <it>post hoc </it>on baseline items of the 21-Item Hamilton Depression Rating Scale (HDRS-21) and Young Mania Rating Scale (YMRS). Backwards-elimination logistic regression ascertained factors predictive of protocol-defined endpoint remission (HDRS-21 score ≤ 8 and YMRS score ≤ 12) with subsequent determination of optimally predictive factor score cutoffs.</p> <p>Factors for Psychomotor activity (YMRS items for elevated mood, increased motor activity, and increased speech and HDRS-21 agitation item) and Guilt/Suicidality (HDRS-21 items for guilt and suicidality) significantly predicted endpoint remission in the divalproex+olanzapine group. No factor predicted remission in the divalproex+placebo group. Patients in the divalproex+olanzapine group with high pre-augmentation psychomotor activity (scores ≥10) were more likely to remit compared to those with lower psychomotor activity (odds ratio [OR] = 3.09, 95% confidence interval [CI] = 1.22-7.79), and patients with marginally high Guilt/Suicidality (scores ≥2) were less likely to remit than those with lower scores (OR = 0.37, 95% CI = 0.13-1.03). Remission rates for divalproex+placebo vs. divalproex+olanzapine patients with high psychomotor activity scores were 22% vs. 45% (p = 0.08) and 33% vs. 48% (p = 0.29) for patients with low Guilt/Suicidality scores.</p> <p>Conclusions</p> <p>Patients who were partially nonresponsive to divalproex treatment with remaining high vs. low psychomotor activity levels or minimal vs. greater guilt/suicidality symptoms were more likely to remit with olanzapine augmentation.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov; <url>http://clinicaltrials.gov/ct2/show/NCT00402324?term=NCT00402324&rank=1</url>, Identifier: NCT00402324</p