Lunar Exploration Orbiter (LEO): Providing a Globally Covered, Highly Resolved, Integrated Geological, Geochemical and Gephysical Data Base of the Moon

The German initiative for the Lunar Exploration Orbiter (LEO) originated from the national conference “Exploration of our Solar System”, held in Dresden in November 2006. Major result of this conference was that the Moon is of high interest for the scientific community for various reasons, it is affordable to perform an orbiting mission to Moon and it insures technological and scientific progress necessary to assist further exploration activities of our Solar System. Based on scientific proposals elaborated by 50 German scientists in January 2007, a preliminary payload of 12 instruments was defined. Further analysis were initated by DLR in the frame of two industry contracts, to perform a phase-zero mission definition. The Moon, our next neighbour in the Solar System is the first choice to learn, how to work and live without the chance of immediate support from earth and to get prepared for further and farther exploration missions. We have to improve our scientific knowledge base with respect to the Moon applying modern and state of the art research tools and methods. LEO is planed to be launched in 2012 and shall orbit the Moon for about four years in a low altitude orbit

Mars 94/96 Pushbroom Cameras: Plans for Ground Data Processing and Analysis

The ground data processing system for the HRSC and WAOSS stereo scanner systems on board the Russian Mars 94/96 missions is currently being developed by DLR. The system involves software to generate decompressed, decalibrated, and geometrically corrected standard photo products for expected 200 GB of image data, and in addition DEMs, orthoimages and various topographic and thematic image maps for selected imagery. Other software is being developed for the analysis of compositional properties of the surface and for studies of the Martian atmosphere. all software will be based on the VICAR/SPICE environment and will be designed to operate on the hardware platforms DEC AXP, SUN, and SG. Data will be archived on CD-ROMs in PDS formats to facilitate data exchange among an international team of experiment Co-Investigators

A Dedicated Small Lunar Exploration Orbiter and a Mobile Surface Element

The Moon is an integral part of the Earth-Moon system, it is a witness to more than 4.5 b. y. of solar system history, and it is the only planetary body except Earth for which we have samples from known locations. The Moon is thus a key object to understand our Solar System. The Moon is our closest companion and can easily be reached from Earth at any time, even with a relatively modest financial budget. Consequently, the Moon was the first logical step in the exploration of our solar system before we pursued more distant targets such as Mars and beyond. The vast amount of knowledge gained from the Apollo and other lunar missions of the late 1960's and early 1970's demonstrates how valuable the Moon is for the understanding of our planetary system (e.g. [1], [2]). Even today, the Moon remains an extremely interesting target scientifically and technologically. New data have helped to address some of our questions about the Earth-Moon system, but many remain and new questions arose. In particular, the discovery of water at the lunar poles, and water and hydroxyl bearing surface materials and volatiles, as well as the discovery of young volcanism have changed our view of the Moon. Therefore, returning to the Moon is the critical stepping-stone to further exploring our immediate planetary neighborhood. Here, we present scientific and technological arguments for a Small Lunar Explorations Orbiter (S-LEO) dedicated to investigate so far unsolved questions and processes. Numerous space-faring nations have realized and identified the unique opportunities related to lunar exploration and have planned missions to the Moon within the next few years. Among these missions, S-LEO will be unique, because of its unprecedented spatial and spectral resolutions. S-LEO will significantly improve our understanding of the lunar environment in terms of composition, surface ages, mineralogy, physical properties, and volatile and regolith processes. S-LEO will carry an entire suite of innovative, complementary technologies, including high-resolution camera systems, several spectrometers that cover previously unexplored parts of the electromagnetic spectrum over a broad range of wavelengths, and a communication system to interact with landed equipment on the farside. The Small Lunar Explorations Orbiter concept is technologically challenging but feasible, and will gather unique, integrated, interdisciplinary data sets that are of high scientific interest and will provide an unprecedented new context for all other international lunar missions. The most visible mission goal of S-LEO will be the identification and mapping of lunar volatiles and investigating their origin and evolution with high spatial as well as spectral resolution. Therefore, in addition to mapping the geological context in the sub-meter range, a screening of the electromagnetic spectrum within a very broad range will be performed. In particular, spectral mapping in the ultraviolet and mid-infrared will provide insight into mineralogical and thermal properties so far unexplored in these wavelength ranges. The determination of the dust distribution in the lunar orbit will provide information about processes between the lunar surface and exosphere supported by direct observations of lunar flashes. Measuring of the radiation environment will finally complete the exosphere investigations. Combined observations based on simultaneous instrument adjustment and correlated data processing will provide an integrated geological, geochemical and geophysical database that enables: • the exploration and utilization of the Moon in the 21st century; • the solution of fundamental problems of planetology concerning the origin and evolution of terrestrial bodies; • understanding the uniqueness of the Earth-Moon System and its formation and evolution; • the absolute calibration of the impact chronology for the dating of solar system processes; • deciphering the lunar regolith as record for space environmental conditions; • mapping lunar resources. S-LEO is featuring a set of unique scientific capabilities w.r.t. other planned missions including: (1) dedicated observation of volatiles (mainly H2O and OH), their formation and evolution in direct context with the geological and mineralogical surface with high spectral and spatial resolution (< 1m/px); (2) besides the VIS-NIR spectral range so far uncovered wavelengths in the ultraviolet (0.2 – 0.4 µm) and mid-infrared (7 - 14 µm) will be mapped to provide mineralogical context for volatile processes (e.g. sources of oxygen); (3) detection of rock-forming elements by means of x-ray fluorescence in the spectral range of .5-10 keV in order to constrain the composition of key elements of lunar surface materials; (4) monitoring of dust and radiation in the lunar environment and its interaction with the surface; and (5) monitoring of present-day meteoroitic impacts. In 2009 ESA commissioned a Mobile Payload Element (MPE) to assist the ESA Lunar Lander mission. The MPE, currently under study in Germany, is designed to be a small, autonomous, innovative vehicle of roughly 10 12 kg for scouting the environment in the vicinity of the lunar landing site. The novel capability of the MPE will be to acquire samples of lunar soil in an area of >100m around the lander and to bring them back to the spacecraft for analysis by on-board instruments. This will enable access to soils that are less contaminated by the descent propulsion system plumes to increase the chances of detection of any indigenous lunar volatiles. The MPE shall acquire samples of regolith with landing-induced contamination being below the detection limit of the associated volatile-seeking instruments. Subsurface regolith sampling is preferable to understand the concentration of volatiles as a function of depth. Additional benefits for the overall science accomplished by a Lunar Lander mission could be obtained if the MPE were to conduct ‘field geology’ type observations and measurements along its traverses, such as geochemical and mineralogical in situ investigations with dedicated instruments on rocks, boulders and regolith. This would dramatically expand the effective area studied by the ESA Lunar Lander mission. Based on technology trades the baseline concept for the MPE system is composed by a 4-wheel active chassis with wheels, a power supply with fixed solar generators plus a secondary battery, a thermal system with active heating and passive insulation, a sensor package for autonomous operations and a VHF/UHF communication system between MPE and the Lander. One unique scientific aspect of the MPE could be the in situ study of rocks, boulders and lithic (rock) fragments which otherwise would only be amenable to measurements using any instrument heads mounted on the lander robotic arm (provided any rocks were within reach of the arm). To fulfill the science objectives, the MPE will be equipped with a stereo camera, the PLUTO mole subsurface regolith sampling system (as flown on Beagle 2) as well as a close-up imager. This instrument package allows acquisition of regolith samples from both illuminated and locally shaded terrain, sampling from the subsurface and from underneath large boulders and documentation of the samples acquired by close-up imaging of the sample site, ideally before and after sample acquisition. A suite of terrain temperature sensors is implicitly included to provide context for the samples acquired from permanently shadowed locations or below the surface, but also to contribute to landing site general science. As an option for the in-situ characterization of the sample material with respect to mineralogy and possibly volatile content, spectrometer experiments or a color capability of the camera could be added. Further, a laboratory environment is currently being established at Freie Universität Berlin in order to allow sample-based geochemical measurements of key rock-forming elements in the soft X-Ray domain (.5-10 keV). The laboratory is used for the hardware development of X-Ray spectrometer experiments to be employed on lunar orbiter and on lunar lander missions. References: [1] H. Hiesinger, J.W. Head, New Views of Lunar Geoscience: An Introduction and Overview, In: Ne Views of the Moon (B.L. Jolliff et al. eds.) Rev. Min. Geochem., 60, 1-81 (2006). [2] R. Jaumann, The Moon, In: Encyclopedia of Astrobiology, M. Gargaud et al. (eds.), Vol. 2, Springer, 280-282 (2011)

Waste types in people processing services

The globalization needs and the increased competition between all types of companies put an increased focus on service improvement. Services are mostly customized, intangible, knowledge-based, and one type of services, called here as People Processing Services (PPS), can have the direct participation of customers both as object being processed and as a co-producer. These characteristics of PPS make it difficult to standardize processes, which contribute for generating non-value added activities, classified as wastes in the Lean Thinking knowledge area. This work aims to contribute to the waste classification, proposing a clarification for the types of waste associated with People Processing Services, and further applying this classification to a particular PPS case, the Hip Surgery Production Process of a Portuguese Public Hospital. It was observed that a large number of activities do not add value to the service and waiting is the most common waste.info:eu-repo/semantics/publishedVersio

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes

Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This modification is catalyzed by the glutaminyl cyclases QC and isoQC. Here, we decipher the roles of the isoenzymes by characterization of IsoQC(-/-) mice. These mice show a significant reduction of glutaminyl cyclase activity in brain and peripheral tissue, suggesting ubiquitous expression of the isoQC enzyme. An assay of substrate conversion in vivo reveals impaired generation of the pGlu-modified C-C chemokine ligand 2 (CCL2, MCP-1) in isoQC(-/-) mice. The pGlu-formation was also impaired in primary neurons, which express significant levels of QC. Interestingly, however, the formation of the neuropeptide hormone thyrotropin-releasing hormone (TRH), assessed by immunohistochemistry and hormonal analysis of hypothalamic-pituitary-thyroid axis, was not affected in isoQC(-/-), which contrasts to QC(-/-). Thus, the results reveal differential functions of isoQC and QC in the formation of the pGlu-peptides CCL2 and TRH. Substrates requiring extensive prohormone processing in secretory granules, such as TRH, are primarily converted by QC. In contrast, protein substrates such as CCL2 appear to be primarily converted by isoQC. The results provide a new example, how subtle differences in subcellular localization of enzymes and substrate precursor maturation might influence pGlu-product formation

The high-resolution stereo camera (HRSC) experiment on Mars Express: Instrument aspects and experiment conduct from interplanetary cruise through nominal mission

ESA's Mars Express has successfully completed its nominal mission of one Martian year covering about 25% of the surface in stereo and color with resolutions up to 10 m/pixel by its high-resolution stereo camera (HRSC). Mars Express is now in its extended mission phase, during which much of the remaining part of the Martian surface is envisaged to be covered in stereo and color. The HRSC instrument is designed to map the morphology, topography, structure and geologic context of the surface as well as atmospheric phenomena. This paper discusses the measurement principles and operations of the instrument as well as the acquisition, calibration and processing of regional and global data sets. As HRSC is a push-broom scanning instrument with nine CCD line detectors mounted in parallel on a focal plane, its unique feature is the ability to obtain near-simultaneous imaging data at high resolution, with along-track triple stereo, four colors and five different phase angles, avoiding any time-dependent variations of the observing conditions. The HRSC spatial resolution is 10 m/pixel at the nominal periapsis altitude of 250 km, with an image swath of 53 km, and 2.3 m/pixel for an additional framing CCD device, called super resolution channel (SRC), practically working as an additional tenth channel of the HRSC and yielding nested-in black and white images for studies of small-scale geologic features. The sub-pixel accuracy of the three-dimensional point determination allows the derivation of digital terrain models (DTMs) with a grid size of up to 50 m and a height accuracy of a single pixel with up to 10 m, thus enabling us to carry out detailed quantitative analyses of the surface structure. The HRSC (1) bridges the gap between the medium–high-resolution Viking imagery and the very-high-resolution Global Surveyor mission, thus providing geological context, and (2) fills the gaps in the three-dimensional coverage and DTM grid of the MOLA laser altimetry data, and (3) helps characterize landing sites for in-situ measurements. HRSC also builds the basis for extended compositional mapping when combining spectral information with topographic photomaps over large areas. So far the HRSC measurements have made a significant contribution to the study of the evolution of volcanism and the role of water and ice throughout the Martian history

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

Acute and chronic inflammatory disorders are characterized by detrimental cytokine and chemokine expression. Frequently, the chemotactic activity of cytokines depends on a modified N-terminus of the polypeptide. Among those, the N-terminus of monocyte chemoattractant protein 1 (CCL2 and MCP-1) is modified to a pyroglutamate (pE-) residue protecting against degradation in vivo. Here, we show that the N-terminal pE-formation depends on glutaminyl cyclase activity. The pE-residue increases stability against N-terminal degradation by aminopeptidases and improves receptor activation and signal transduction in vitro. Genetic ablation of the glutaminyl cyclase iso-enzymes QC (QPCT) or isoQC (QPCTL) revealed a major role of isoQC for pE(1)-CCL2 formation and monocyte infiltration. Consistently, administration of QC-inhibitors in inflammatory models, such as thioglycollate-induced peritonitis reduced monocyte infiltration. The pharmacologic efficacy of QC/isoQC-inhibition was assessed in accelerated atherosclerosis in ApoE3*Leiden mice, showing attenuated atherosclerotic pathology following chronic oral treatment. Current strategies targeting CCL2 are mainly based on antibodies or spiegelmers. The application of small, orally available inhibitors of glutaminyl cyclases represents an alternative therapeutic strategy to treat CCL2-driven disorders such as atherosclerosis/restenosis and fibrosis