Ethnicity-specific obesity cut-points in the development of Type 2 diabetes - a prospective study including three ethnic groups in the United Kingdom

Aims: Conventional definitions of obesity, e.g. body mass index (BMI) ≥ 30 kg/m2 or waist circumference cut-points of 102 cm (men) and 88 cm (women), may underestimate metabolic risk in non-Europeans. We prospectively identified equivalent ethnicity-specific obesity cut-points for the estimation of diabetes risk in British South Asians, African-Caribbeans and Europeans. Methods: We studied a population-based cohort from London, UK (1356 Europeans, 842 South Asians, 335 African-Caribbeans) who were aged 40–69 years at baseline (1988–1991), when they underwent anthropometry, fasting and post-load (75 g oral glucose tolerance test) blood tests. Incident Type 2 diabetes was identified from primary care records, participant recall and/or follow-up biochemistry. Ethnicity-specific obesity cut-points in association with diabetes incidence were estimated using negative binomial regression. Results: Diabetes incidence rates (per 1000 person years) at a median follow-up of 19 years were 20.8 (95% CI: 18.4, 23.6) and 12.0 (8.3, 17.2) in South Asian men and women, 16.5 (12.7, 21.4) and 17.5 (13.0, 23.7) in African-Caribbean men and women, and 7.4 (6.3, 8.7), and 7.2 (5.3, 9.8) in European men and women. For incidence rates equivalent to those at a BMI of 30 kg/m2 in European men and women, age- and sex-adjusted cut-points were: South Asians, 25.2 (23.4, 26.6) kg/m2; and African-Caribbeans, 27.2 (25.2, 28.6) kg/m2. For South Asian and African-Caribbean men, respectively, waist circumference cut-points of 90.4 (85.0, 94.5) and 90.6 (85.0, 94.5) cm were equivalent to a value of 102 cm in European men. Waist circumference cut-points of 84.0 (74.0, 90.0) cm in South Asian women and 81.2 (71.4, 87.4) cm in African-Caribbean women were equivalent to a value of 88 cm in European women. Conclusions: In prospective analyses, British South Asians and African-Caribbeans had equivalent diabetes incidence rates at substantially lower obesity levels than the conventional European cut-points

Berry's phase for coherent states of Landau levels

The Berry phases for coherent states and squeezed coherent states of Landau levels are calculated. Coherent states of Landau levels are interpreted as a result of a magnetic flux moved adiabatically from infinity to a finite place on the plane. The Abelian Berry phase for coherent states of Landau levels is an analog of the Aharonov- Bohm effect. Moreover, the non-Abelian Berry phase is calculated for the adiabatic evolution of the magnetic field B.Comment: 4 pages, 1 figur

Particle alignments and shape change in 66^{66}Ge and 68^{68}Ge

The structure of the $N \approx Z$ nuclei $^{66}$Ge and $^{68}$Ge is studied by the shell model on a spherical basis. The calculations with an extended $P+QQ$ Hamiltonian in the configuration space ($2p_{3/2}$, $1f_{5/2}$, $2p_{1/2}$, $1g_{9/2}$) succeed in reproducing experimental energy levels, moments of inertia and $Q$ moments in Ge isotopes. Using the reliable wave functions, this paper investigates particle alignments and nuclear shapes in $^{66}$Ge and $^{68}$Ge. It is shown that structural changes in the four sequences of the positive- and negative-parity yrast states with even $J$ and odd $J$ are caused by various types of particle alignments in the $g_{9/2}$ orbit. The nuclear shape is investigated by calculating spectroscopic $Q$ moments of the first and second $2^+$ states, and moreover the triaxiality is examined by the constrained Hatree-Fock method. The changes of the first band crossing and the nuclear deformation depending on the neutron number are discussed.Comment: 18 pages, 21 figures; submitted to Phys. Rev.

A Survey on Modeling Line Commutated Converter HVDC Transmission Systems

This paper review about the dynamic phasor model of a line-commutated converter (LCC) high-voltage direct current (HVDC) transmission system. The mathematical definition and properties of dynamic phasors are utilized to model both the dc-side and the ac-side of a LCC-HVDC transmission system as well as 6-pulse Graetz Bridge, which is the building block of such a system. The developed model includes low-frequency dynamics of the systems, i.e., fundamental frequency component (50 Hz) at the ac-side and dc component at the dc-side, and removes high-frequency transients. The developed model, however, is capable of accommodating higher harmonics if necessary. The model is also able to simulate the system during abnormal modes of operations such as unbalanced operation and commutation failure. In order to develop the dynamic phasor model of a line-commutated converter, the concept of switching functions is utilized. The developed model is capable of capturing large-signal transients of the system as well as steady state operating conditions. The model can be used in order to decrease the computational intensity of LCC-HVDC simulations

Coronary artery disease epidemic in Pakistan: more electrocardiographic evidence of ischaemia in women than in men

Indo-Pakistani populations have one of the highest risks of coronary artery disease (CAD) in the world. A population-based, cross-sectional survey was conducted on 3143 adults aged ⩾40 years from 12 randomly selected communities in Karachi, Pakistan. Apart from smoking, women had more CAD risk factors (diabetes, hypertension, obesity, dyslipidaemia) than men. Definite CAD (history and Q waves on ECG) was more prevalent in men than in women (6.1% vs 4.0%; p = 0.009). In contrast, ischaemic and major ECG changes were twice as prevalent in women as in men (29.4% vs 15.6%, and 21.0% vs 10.5%; p<0.001 for each, respectively). All measures of CAD were strongly predicted by the metabolic syndrome, but that failed to account for the greater prevalence of ECG abnormalities in women than in men. The findings indicate that one in five middle-aged adults in urban Pakistan may have underlying CAD. Women are at greater risk than men

Thigh fat and muscle each contribute to excess cardiometabolic risk in South Asians, independent of visceral adipose tissue.

OBJECTIVE: To compare fat distribution and associations between fat depots and cardiometabolic traits in South Asians and Europeans. METHODS: Five hundred and fourteen South Asians and 669 Europeans, aged 56-86. Questionnaires, record review, blood testing, and coronary artery calcification scores provided diabetes and clinical plus subclinical coronary heart disease (CHD) diagnoses. Abdominal visceral (VAT) and subcutaneous adipose tissue, thigh subcutaneous adipose tissue (TSAT), intermuscular and intramuscular thigh fat and thigh muscle were measured by CT. RESULTS: Accounting for body size, South Asians had greater VAT and TSAT than Europeans, but less thigh muscle. Associations between depots and disease were stronger in South Asians than Europeans. In multivariable analyses in South Asians, VAT was positively associated with diabetes and CHD, while TSAT and thigh muscle were protective for diabetes, and thigh muscle for CHD. Differences in VAT and thigh muscle only partially explained the excess diabetes and CHD in South Asians versus Europeans. Insulin resistance did not account for the effects of TSAT or thigh muscle. CONCLUSIONS: Greater VAT and TSAT and lesser thigh muscle in South Asians contributed to ethnic differences in cardiometabolic disease. Effects of TSAT and thigh muscle were independent of insulin resistance

The Vlasov--Poisson--Landau system in the weakly collisional regime

Consider the Vlasov--Poisson--Landau system with Coulomb potential in the weakly collisional regime on a $3$-torus, i.e. $$\begin{aligned} \partial_t F(t,x,v) + v_i \partial_{x_i} F(t,x,v) + E_i(t,x) \partial_{v_i} F(t,x,v) = \nu Q(F,F)(t,x,v),\\ E(t,x) = \nabla \Delta^{-1} (\int_{\mathbb R^3} F(t,x,v)\, \mathrm{d} v - \frac{1}{(2\pi)^3}\int_{\mathbb T^3} \int_{\mathbb R^3} F(t,x,v)\, \mathrm{d} v \, \mathrm{d} x), \end{aligned}$$ with $\nu\ll 1$. We prove that for $\epsilon>0$ sufficiently small (but independent of $\nu$), initial data which are $O(\epsilon \nu^{1/3})$-Sobolev space perturbations from the global Maxwellians lead to global-in-time solutions which converge to the global Maxwellians as $t\to \infty$. The solutions exhibit uniform-in-$\nu$ Landau damping and enhanced dissipation. Our main result is analogous to an earlier result of Bedrossian for the Vlasov--Poisson--Fokker--Planck equation with the same threshold. However, unlike in the Fokker--Planck case, the linear operator cannot be inverted explicitly due to the complexity of the Landau collision operator. For this reason, we develop an energy-based framework, which combines Guo's weighted energy method with the hypocoercive energy method and the commuting vector field method. The proof also relies on pointwise resolvent estimates for the linearized density equation.Comment: 78 Pages. Comments welcome

Tooth-Support over Dentures: An approach to Preventive Prosthodontics

Over denture is a favoured treatment modality for elderly patients with few remaining teeth. Roots maintained under the denture base preserve the alveolar ridge, provide sensory feedback and improve the stability of the dentures. The concept of conventional tooth-retained over dentures is a simple and cost effective treatment than the implant over dentures. When few firm teeth are present in an otherwise compromised dentition, they can be retained and used as abutments for over denture fabrication. The concept of over dentures may not be the elixir, but it is a positive means for delaying the process of complete endentulism and helps in the preservation of bone. To top it all, it gives the patient the satisfaction of having prosthesis with his natural teeth still present. The present case reports discuss the rehabilitation of an edentulous patient with a tooth supported over denture with metal copings

Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men.

It is unknown whether associations between blood pressure (BP) and stroke vary between Europeans and South Asians, despite higher stroke rates in the latter. We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988-1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for age, smoking status, waist/hip ratio, total/high-density lipoprotein-cholesterol ratio, diabetes mellitus, fasting glucose, physical activity, and heart rate (systolic BP: Europeans [odds ratio, 1.22; 95% confidence interval, 0.98-1.51], South Asians [1.56; 1.24-1.95]; ethnic difference P=0.04; diastolic BP: Europeans [0.90; 0.71-1.13], South Asians [1.68; 1.32-2.15]; P<0.001). Hemodynamic correlates of stroke risk differed by ethnicity: in combined models, mean arterial pressure but not pulse pressure was detrimentally associated with stroke in South Asians, whereas the converse was true for Europeans. The combination of hyperglycemia and hypertension appeared particularly detrimental for South Asians. There are marked ethnic differences in associations between BP parameters and stroke. Undue focus on systolic BP for risk prediction, and current age and treatment thresholds may be inappropriate for individuals of South Asian ancestry