Event-by-Event Search for Charged Neutral Fluctuations in Pb - Pb Collisions at 158-A-GeV

Results from the analysis of data obtained from the WA98 experiment at the CERN SPS have been presented. Some events have been filtered which show photon excess in limited $\eta-\phi$ zones within the overlap region of the charged particle and photon multiplicity detectors.Comment: 6 pages, 4 figure

Age-related decrease in rod bipolar cell density of the human retina: an immunohistochemical study

During normal ageing, the rods (and other neurones) undergo a significant decrease in density in the human retina from the fourth decade of life onward. Since the rods synapse with the rod bipolar cells in the outer plexiform layer, a decline in rod density (mainly due to death) may ultimately cause an associated decline of the neurones which, like the rod bipolar cells, are connected to them. The rod bipolar cells are selectively stained with antibodies to protein kinase C-α. This study examined if rod bipolar cell density changes with ageing of the retina, utilizing donor human eyes (age: 6-91 years). The retinas were fixed and their temporal parts from the macula to the mid-periphery sectioned and processed for protein kinase C-α immunohistochemistry. The density of the immunopositive rod bipolar cells was estimated in the mid-peripheral retina (eccentricity: 3-5 mm) along the horizontal temporal axis. The results show that while there is little change in the density of the rod bipolar cells from 6 to 35 years (2.2%), the decline during the period from 35 to 62 years is about 21% and between seventh and tenth decades, it is approximately 27%

Systematic study of high-pTp_T hadron and photon production with the PHENIX experiment

The suppression of hadrons with large transverse momentum ($p_{\rm T}$) in central Au+Au collisions at $\sqrt{s_{\rm NN}}$ = 200 GeV compared to a binary scaled p+p reference is one of the major discoveries at RHIC. To understand the nature of this suppression PHENIX has performed detailed studies of the energy and system-size dependence of the suppression pattern, including the first RHIC measurement near SPS energies. An additional source of information is provided by direct photons. Since they escape the medium basically unaffected they can provide a high $p_{\rm T}$ baseline for hard-scattering processes. An overview of hadron production at high $p_{\rm T}$ in different colliding systems and at energies from $\sqrt{s_{\rm NN}} = 22.4 - 200$ GeV will be given. In addition, the latest direct photon measurements by the PHENIX experiment shall be discussed.Comment: 6 pages, 3 figures, Proceeding for the Conference Strangeness in Quark Matter, Levoca, Slovakia, June 24-29, 200

New results from fluctuation analysis in NA49 at the CERN SPS

The exploration of the phase diagram of strongly interacting matter, particularly the study of the phase transition from hadronic to partonic matter and the search for a hypothetical critical endpoint of the first order transition line, is one of the most challenging tasks in present heavy ion physics. In this talk new results on chemical (particle ratio), transverse momentum, multiplicity and azimuthal angle fluctuations will be presented. We also discuss their connection to the onset of deconfinement and to the critical endpoint.Comment: The Proceedings of the International Conference "Critical Point and Onset of Deconfinement - CPOD 2011", Wuhan, November 7-11, 201

Do patient access schemes for high-cost cancer drugs deliver value to society?-lessons from the NHS Cancer Drugs Fund.

BACKGROUND: The NHS Cancer Drugs Fund (CDF) was established in 2010 to reduce delays and improve access to cancer drugs, including those that had been previously appraised but not approved by NICE (National Institute for Health and Care Excellence). After 1.3 billion GBP expenditure, a UK parliamentary review in 2016 rationalized the CDF back into NICE. METHODS: This paper analyses the potential value delivered by the CDF according to six value criteria. This includes validated clinical benefits scales, cost-effectiveness criteria as defined by NICE and an assessment of real-world data. The analysis focuses on 29 cancer drugs approved for 47 indications that could be prescribed through the CDF in January 2015. RESULTS: Of the 47 CDF approved indications, only 18 (38%) reported a statistically significant OS benefit, with an overall median survival of 3.1 months (1.4-15.7 months). When assessed according to clinical benefit scales, only 23 (48%) and 9 (18%) of the 47 drug indications met ASCO and ESMO criteria, respectively. NICE had previously rejected 26 (55%) of the CDF approved indications because they did not meet cost-effectiveness thresholds. Four drugs-bevacizumab, cetuximab, everolimus and lapatinib-represented the bulk of CDF applications and were approved for a total of 18 separate indications. Thirteen of these indications were subsequently delisted by the CDF in January 2015 due to insufficient evidence for clinical benefit-data which were unchanged since their initial approval. CONCLUSIONS: We conclude the CDF has not delivered meaningful value to patients or society. There is no empirical evidence to support a 'drug only' ring fenced cancer fund relative to concomitant investments in other cancer domains such as surgery and radiotherapy, or other noncancer medicines. Reimbursement decisions for all drugs and interventions within cancer care should be made through appropriate health technology appraisal processes

Characteristics, seasonality and sources of carbonaceous and ionic components in the tropical aerosols from Indian region

To better characterize the tropical aerosols in Indian region, PM<sub>10</sub> samples collected from Chennai, India (13.04° N; 80.17° E) were analyzed for carbonaceous and water-soluble ionic components. Concentration ranges of elemental carbon (EC) and organic carbon (OC) were 2.4–14 μg m<sup>−3</sup> (ave. 6.5 μg m<sup>−3</sup>) and 3.2–15.6 μg m<sup>−3</sup> (ave. 9.1 μg m<sup>−3</sup>) in winter samples whereas they were 1.1–2.5 μg m<sup>−3</sup> (ave. 1.6 μg m<sup>−3</sup>) and 4.1–17.6 μg m<sup>−3</sup> (ave. 9.7 μg m<sup>−3</sup>) in summer samples, respectively. Concentration of secondary organic carbon (SOC) retrieved from EC-tracer method was 4.6±2.8 μg m<sup>−3</sup> in winter and 4.3±2.8 μg m<sup>−3</sup> in summer. OC accounted for 38.5±14 % (<i>n</i> = 49) of combined concentrations of carbonaceous and ionic components in PM<sub>10</sub>. We also found that OC concentrations are generally higher than those of SO<sub>4</sub><sup>2−</sup> (8.8±2.5 μg m<sup>−3</sup> and 4.1±2.7 μg m<sup>−3</sup> in winter and summer, respectively), which was the most abundant ionic species (57 %) followed by NH<sub>4</sub><sup>+</sup> (15 %) >NO<sub>3</sub><sup>−</sup>>Cl<sup>−</sup>>K<sup>+</sup>>Na<sup>+</sup>> Ca<sup>2+</sup>>MSA<sup>−</sup>>Mg<sup>2+</sup>. The mass fractions of EC, organic matter (OM) and ionic species varied seasonally, following the air mass trajectories and corresponding source strength. Based on mass concentration ratios of selected components and relations of EC and OC to marker species, we found that biofuel/biomass burning is a major source of atmospheric aerosols in South and Southeast Asia. The high concentrations of SOC and WSOC/OC ratios (ave. 0.45; <i>n</i> = 49) as well as good correlations between SOC and WSOC suggest that the secondary production of organic aerosols during long-range atmospheric transport is also significant in this region. This study provides the baseline data of carbonaceous aerosols for southern part of the Indian subcontinent

Imaging Hepatocellular Carcinoma With 68Ga-Citrate PET: First Clinical Experience.

While cross-sectional imaging with computed tomography (CT) and magnetic resonance imaging is the primary method for diagnosing hepatocellular carcinoma (HCC), they provide little biological insight into this molecularly heterogeneous disease. Nuclear imaging tools that can detect molecular subsets of tumors could greatly improve diagnosis and management of HCC. To this end, we conducted a patient study to determine whether HCC can be resolved using 68Ga-citrate positron emission tomography (PET). One patient with recurrent HCC was injected with 300 MBq of 68Ga-citrate and imaged with PET/CT 249 minutes post injection. Four (28%) of 14 hepatic lesions were avid for 68Ga-citrate. One extrahepatic lesion was not PET avid. The average maximum standardized uptake value (SUVmax) for the lesions was 7.2 (range: 6.2-8.4), while the SUVmax of the normal liver parenchyma was 4.7 and blood pool was 5.7. The avid lesions were not significantly larger than the quiescent lesions, and a prior contrast CT showed uniform enhancement among the lesions, suggesting that tumor signals are due to specific binding of the radiotracer to the transferrin receptor, rather than enhanced vascularity in the tumor microenvironment. Further studies are required in a larger patient cohort to verify the molecular basis of radiotracer uptake and the clinical utility of this tool

Experimental Signatures of Anomaly Induced DCC Formation

We discuss characteristic experimental signatures related to the formation of domains of disoriented chiral condensate (DCC) triggered by the axial anomaly in relativistic heavy ion collisions. We predict that the enhancement of the fraction of neutral pions compared to all pions depends on the angle of emission with respect to the scattering plane and is concentrated at small transverse momentum and small rapidity in the center-of-mass frame. The anisotropy with respect to the reaction plane is also observable in the inclusive photon distribution.Comment: 11 pages, 4 figures, REVTEX, discussion on photon distribution added, one figure adde

Carrier relaxation dynamics in defect states of epitaxial GaN/AlN/Si using ultrafast transient absorption spectroscopy

The relaxation dynamics of the carriers through the defect levels in an epitaxial GaN film grown with an AlN buffer layer on Si has been performed on the femto-picosecond timescale, using ultrafast transient absorption spectroscopy (UFTS). The sample was pumped above and below the band gap and probed with a white light continuum (480-800 nm). A combination of bi and triple exponential decay functions at different probe wavelengths were used to fit the kinetic profile of the carriers in the defect continuum. Based on the UFTS measurements, a model is proposed which explains the dynamics in the shallow traps and deep level defects. Furthermore, to determine the role of the lattice in the relaxation dynamics, the experiment was conducted at a low lattice temperature of 4.2 K. The relaxation constants from the UFTS measurements confirm not only the presence of shallow and deep level defects but also the involvement of phonons in one of the relaxation processes

Synthetic sequence generator for recommender systems - memory biased random walk on sequence multilayer network

Personalized recommender systems rely on each user's personal usage data in the system, in order to assist in decision making. However, privacy policies protecting users' rights prevent these highly personal data from being publicly available to a wider researcher audience. In this work, we propose a memory biased random walk model on multilayer sequence network, as a generator of synthetic sequential data for recommender systems. We demonstrate the applicability of the synthetic data in training recommender system models for cases when privacy policies restrict clickstream publishing.Comment: The new updated version of the pape