Orchestrating ongoing interaction flows of strategy formation in and between meetings

Research has addressed how the practices and organization of strategy meetings shape strategy processes and outcomes. However, how interactive processes run between and feed into meetings—an integral aspect of how managers shape ongoing strategy emergence—remains relatively poorly understood. Through a strong processual-interactionist approach, we thus examine how in- and between-meeting practices interact and create combined effects in orchestrating ongoing flows of strategy formation. By considering strategy meetings as part of and punctuating chain-like, interactive processes of strategy formation, we develop an understanding of how in- and between-meeting practices dynamically interact—they enable, balance the effects of, and shape one another through the interaction flows in which they are engaged. The longitudinal case study reveals and explains the role of cross-over effects and coalescing between multiple simultaneous interaction flows, thereby advancing extant research on how series of interaction sequences shape strategy emergence and evolution

Institutional work within the boundaries of multi-stakeholder initiatives: the relational agency of implementing partners and women cotton-pickers in practice change

In Pakistan, cotton is picked by women who witness first-hand the social and environmental challenges of the global textile industry, which the BCI, a multi-stakeholder initiative (MSI), aims to mitigate. Scholars have yet to investigate the ability of MSIs to achieve change, that experienced by the cotton-pickers themselves. This article offers an original perspective on how relational agency is exerted between an MSI, implementing partners and cotton-pickers, through the mutually interacting work of creating boundaries around an institutional space. This helps explain how, in an otherwise highly restrictive context, women’s agency is leveraged. Based on 40 qualitative interviews with the BCI cotton-pickers and their implementing partners, the study finds that, through institutional work, cotton-pickers have upgraded their working practices. However, the MSI’s impact depends on its ability to maintain its boundary and corresponding practices. By implication, the women’s poverty continues to be a highly significant limitation on the improvements to their lives

The genetic history of Greenlandic-European contact.

The Inuit ancestors of the Greenlandic people arrived in Greenland close to 1,000 years ago.1 Since then, Europeans from many different countries have been present in Greenland. Consequently, the present-day Greenlandic population has ∼25% of its genetic ancestry from Europe.2 In this study, we investigated to what extent different European countries have contributed to this genetic ancestry. We combined dense SNP chip data from 3,972 Greenlanders and 8,275 Europeans from 14 countries and inferred the ancestry contribution from each of these 14 countries using haplotype-based methods. Due to the rapid increase in population size in Greenland over the past ∼100 years, we hypothesized that earlier European interactions, such as pre-colonial Dutch whalers and early German and Danish-Norwegian missionaries, as well as the later Danish colonists and post-colonial immigrants, all contributed European genetic ancestry. However, we found that the European ancestry is almost entirely Danish and that a substantial fraction is from admixture that took place within the last few generations

Research with Arctic peoples: Unique research opportunities in heart, lung, blood and sleep disorders. Working group summary and recommendations

Arctic peoples are spread over eight countries and comprise 3.74 million residents, of whom 9% are indigenous. The Arctic countries include Canada, Finland, Greenland (Denmark), Iceland, Norway, Russia, Sweden and the United States. Although Arctic peoples are very diverse, there are a variety of environmental and health issues that are unique to the Arctic regions, and research exploring these issues offers significant opportunities, as well as challenges. On July 28-29, 2004, the National Heart, Lung, and Blood Institute and the Canadian Institutes of Health Research co-sponsored a working group entitled Research with Arctic Peoples: Unique Research Opportunities in Heart, Lung, Blood and Sleep Disorders . The meeting was international in scope with investigators from Greenland, Iceland and Russia, as well as Canada and the United States. Multiple health agencies from Canada and the United States sent representatives. Also attending were representatives from the International Union for Circumpolar Health (IUCH) and the National Indian Health Board. The working group developed a set of ten recommendations related to research opportunities in heart, lung, blood and sleep disorders; obstacles and solutions to research implementation; and ways to facilitate international comparisons. These recommendations are expected to serve as an agenda for future research

Human endogenous retroviruses form a reservoir of T cell targets in hematological cancers

Human endogenous retroviruses (HERV) form a substantial part of the human genome, but mostly remain transcriptionally silent under strict epigenetic regulation, yet can potentially be reactivated by malignant transformation or epigenetic therapies. Here, we evaluate the potential for T cell recognition of HERV elements in myeloid malignancies by mapping transcribed HERV genes and generating a library of 1169 potential antigenic HERV-derived peptides predicted for presentation by 4 HLA class I molecules. Using DNA barcode-labeled MHC-I multimers, we find CD8+ T cell populations recognizing 29 HERV-derived peptides representing 18 different HERV loci, of which HERVH-5, HERVW-1, and HERVE-3 have more profound responses; such HERV-specific T cells are present in 17 of the 34 patients, but less frequently in healthy donors. Transcriptomic analyses reveal enhanced transcription of the HERVs in patients; meanwhile DNA-demethylating therapy causes a small and heterogeneous enhancement in HERV transcription without altering T cell recognition. Our study thus uncovers T cell recognition of HERVs in myeloid malignancies, thereby implicating HERVs as potential targets for immunotherapeutic therapies