96 research outputs found
E-QED: Electrical Bug Localization During Post-Silicon Validation Enabled by Quick Error Detection and Formal Methods
During post-silicon validation, manufactured integrated circuits are
extensively tested in actual system environments to detect design bugs. Bug
localization involves identification of a bug trace (a sequence of inputs that
activates and detects the bug) and a hardware design block where the bug is
located. Existing bug localization practices during post-silicon validation are
mostly manual and ad hoc, and, hence, extremely expensive and time consuming.
This is particularly true for subtle electrical bugs caused by unexpected
interactions between a design and its electrical state. We present E-QED, a new
approach that automatically localizes electrical bugs during post-silicon
validation. Our results on the OpenSPARC T2, an open-source
500-million-transistor multicore chip design, demonstrate the effectiveness and
practicality of E-QED: starting with a failed post-silicon test, in a few hours
(9 hours on average) we can automatically narrow the location of the bug to
(the fan-in logic cone of) a handful of candidate flip-flops (18 flip-flops on
average for a design with ~ 1 Million flip-flops) and also obtain the
corresponding bug trace. The area impact of E-QED is ~2.5%. In contrast,
deter-mining this same information might take weeks (or even months) of mostly
manual work using traditional approaches
Insights about Cannabis and Psychosis Using Video Games for Young People with a First Episode of Psychosis, Particularly Those from Black Racialized Communities: Protocol for a Mixed Methods Study
Background: Cannabis use disorder among young people with a first episode of psychosis contributes to relapse, hospitalization, and impaired functioning. However, few studies have examined what young people with early phase psychosis, particularly those from Black racialized communities, understand or appreciate about this relationship, even though they may be at risk. There are no formally tested knowledge translation strategies that disseminate these research findings for young people with emerging psychosis from Black racialized communities. Objective: This study aims to conceptualize what young people with early phase psychosis/cannabis use disorder understand about the relationship between cannabis and psychosis, focusing on people from racialized backgrounds. This study also aims to assess whether the knowledge translation product, the “Back to Reality Series,” increases awareness of the impact of cannabis use on psychosis from the perspectives of young people with emerging psychosis and cannabis use disorder from Black African and Caribbean communities. Methods: Qualitative analysis will reveal themes from qualitative interviews about cannabis and psychosis from the perspectives of young people with emerging psychosis and cannabis use disorder from Black African and Caribbean communities. Perceptions before and after exposure to the Back to Reality Series will be qualitatively analyzed. A control game will be used for comparison, and scores on a quiz after playing the Back to Reality Series will be quantitatively analyzed to establish whether the Back to Reality Series raises awareness of the effects of cannabis on psychosis. An advisory council involving young people from Black communities, family members, and clinicians will bring community perspectives to this research. Results: We began recruiting participants for this study in September 2021. We will complete data collection on demographic and clinical factors, qualitative interviews, and quantitative assessments of the Back to Reality Series. Conclusions: The voices of young people from racialized backgrounds will generate preliminary data to inform early psychosis programs, addressing cannabis use in this population. The findings may advance the use of a new knowledge translation product that deals with gaps in knowledge about cannabis use for people experiencing early phase psychosis, particularly those from racialized communities
Postoperative air leak grading is useful to predict prolonged air leak after pulmonary lobectomy
Quality standards for the management of alcohol-related liver disease: Consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology ARLD special interest group
Effect of smoking on subgingival microflora of patients with periodontitis in Japan
<p>Abstract</p> <p>Background</p> <p>Smoking is a risk factor for periodontitis. To clarify the contribution of smoking to periodontitis, it is essential to assess the relationship between smoking and the subgingival microflora. The aim of this study was to gain an insight into the influence of smoking on the microflora of Japanese patients with periodontitis.</p> <p>Methods</p> <p>Sixty-seven Japanese patients with chronic periodontitis (19 to 83 years old, 23 women and 44 men) were enrolled in the present study. They consisted of 30 smokers and 37 non-smokers. Periodontal parameters including probing pocket depth (PPD) and bleeding on probing (BOP) and oral hygiene status were recorded. Detection of <it>Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Fusobacterium nucleatum/periodonticum, Treponema denticola </it>and <it>Campylobacter rectus </it>in subgingival plaque samples was performed by polymerase chain reaction. Association between the detection of periodontopathic bacteria and smoking status was analyzed by multiple logistic regression analysis and chi-square test.</p> <p>Results</p> <p>A statistically significant association was found between having a PPD ≥ 4 mm and detection of <it>T. denticola, P. intermedia, T. forsythia</it>, or <it>C. rectus</it>, with odds ratios ranging from 2.17 to 3.54. A significant association was noted between BOP and the detection of <it>C. rectus </it>or <it>P. intermedia</it>, and smoking, with odds ratios ranging from 1.99 to 5.62. Prevalence of <it>C. rectus </it>was higher in smokers than non-smokers, whereas that of <it>A. actinomycetemcomitans </it>was lower in smokers.</p> <p>Conclusions</p> <p>Within limits, the analysis of the subgingival microbial flora in smokers and non-smokers with chronic periodontitis suggests a relevant association between smoking and colonization by the specific periodontal pathogens including <it>C. rectus</it>.</p
Improved application technique of albumin-glutaraldehyde glue for repair of superficial lung defects
Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36
OBJECTIVE—Experimental infection of rats with human adenovirus type 36 (Ad-36) promotes adipogenesis and improves insulin sensitivity in a manner reminiscent of the pharmacologic effect of thiozolinediones. To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue
Quality standards for the management of alcohol-related liver disease: consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology ARLD special interest group
Objective Alcohol-related liver disease (ALD) is the most
common cause of liver-related ill health and liver-related
deaths in the UK, and deaths from ALD have doubled
in the last decade. The management of ALD requires
treatment of both liver disease and alcohol use; this
necessitates effective and constructive multidisciplinary
working. To support this, we have developed quality
standard recommendations for the management of ALD,
based on evidence and consensus expert opinion, with the
aim of improving patient care.
Design A multidisciplinary group of experts from the
British Association for the Study of the Liver and British
Society of Gastroenterology ALD Special Interest Group
developed the quality standards, with input from the
British Liver Trust and patient representatives.
Results The standards cover three broad themes: the
recognition and diagnosis of people with ALD in primary
care and the liver outpatient clinic; the management of
acutely decompensated ALD including acute alcoholrelated hepatitis and the posthospital care of people
with advanced liver disease due to ALD. Draft quality
standards were initially developed by smaller working
groups and then an anonymous modified Delphi voting
process was conducted by the entire group to assess
the level of agreement with each statement. Statements
were included when agreement was 85% or greater.
Twenty-four quality standards were produced from this
process which support best practice. From the final
list of statements, a smaller number of auditable key
performance indicators were selected to allow services to
benchmark their practice and an audit tool provided.
Conclusion It is hoped that services will review their
practice against these recommendations and key
performance indicators and institute service development
where needed to improve the care of patients with ALD
Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment
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