Koronaéter alapú királis állófázisok = Crown ether based chiral stationary phases

A gyógyszer-, a növényvédőszer-, élelmiszer- és illatszeriparban nagy jelentőségűek a királis aminok, aminosavak és származékaik enantiomerjeinek elválasztása, mely enantioszelektív komplexképzésük következtében megvalósítható koronaéter alapú királis állófázisokon végzett folyadékkromatográfia módszerével is. A kutatás eredményeként előállítottunk több, piridin, illetve akridin egységet tartalmazó, enantiomertiszta 18-korona-6-éter származékot, melyeket megfelelő oldalkarral elláttunk és ezeket HPLC minőségű szilikagélhez kötve királis állófázishoz jutottunk. Az így kapott királis állófázisok segítségével hatékonyan és nagy szelektivitással választottunk el racém protonált primer aminokat, aminosavakat és azok származékait. | The enantioseparation of chiral protonated primary amines, amino acids and their derivatives is a very important task for pharmaceutical, plant protecting, food and perfume industries. This task can also be accomplished by high-performance liquid chromatography (HPLC) using enantiopure crown ether-based chiral stationary phases (CSPs). As results of our research we prepared several enantiopure 18-crown-6 ethers containing a pyridine or an acridine subunit. We introduced suitable linkers to the crown ethers and the latter derivatives were attached to HPLC quality silica gel by covalent bonds to obtain the CSPs. The CSPs so obtained separated the enantiomers of racemic protonated primary amines, amino acids and their derivatives with great efficiency and high selectivity

Synthesis and molecular recognition studies of crown ethers

This short review summarizes the synthesis and molecular recognition studies of crown ether type macrocycles accomplished at the Institute for Organic Chemistry of Budapest University of Technology and Economics in the last few years. The research work reported here belongs to the areas of proton-ionizable crown ethers and chiral macrocycles. Proton-ionizable crown ethers at higher pHs than their pK_a values are mostly ionized to ligand anions which increase the cation-ligand complex stability with enhancement of selectivity and avoid the need for a counter anion to accompany the cation transport or solvent extraction. The latter factor is not only advantageous from energetical point of view, but is also important when counter anions are not required to be transported. Enantiopure chiral macrocycles have also drawn the attention of many researchers, because owing to their enantioselective complexation they are excellent candidates for effective sensors and selectors of the enantiomers of biologically important chiral compounds such as protonated primary organic amines, amino acids and the derivatives of the latters

An Enigmatic Funnel Find of the Somogyvár-Vinkovci Culture from Balatonőszöd-Temetői dűlő in Transdanubia, Hungary

A small section of an Early Bronze Age settlement made up of pits was uncovered at the prehistoric, multi-period site of Balatonőszöd-Temetői dűlő. In addition to ceramics of the Somogyvár-Vinkovci culture, the finds from Pit 2563 included an enigmatic artefact of baked clay. Despite the fact that analogous archaeological finds and various archaeometric analyses have provided several clues for a conclusive determination of its function, comparable finds nonetheless suggest that it might in all probability be associated with dairying or metalworking

Az Aczélt megedzik : Aczél Tamás A szabadság árnyékában

The study is dealing with somé literary and aesthetical aspects of the politically defined critical discourse under the communist dictatorship, in respect to a növel by Tamás Aczél, which was written after World War II, published in 1948 and awarded Stalin prize in 1952