42 research outputs found
Identifying Genes Involved in Paraganglioma Genesis
The paraganglion system is composed of a collection of chromaffin cells that is
distributed throughout the body. Embryonically, chromaffin cells arise from the
neuroectodermal tissue of the neural crest and are thought to migrate along the
innervating nerves or vasculature towards their primordial location to form the
paraganglia. The largest paraganglion is the adrenal medulla, an important
neuroendocrine organ, which is the bodyâs main source of catecholamines (adrenalin,
noradrenalin and dopamine). The adrenal medulla receives input from the sympathetic
nervous system through preganglionic fibers upon which it releases its secretions directly
into the blood. Besides this adrenal station there are many extraâadrenal paraganglia that
are distributed along the body axis and located in the proximity of ganglia of the
sympathetic chain or in association with cranial nerves and blood vessels
Molecular DNA identity of the mouflon of Cyprus (Ovis orientalis ophion, Bovidae): Near Eastern origin and divergence from Western Mediterranean conspecific populations
The mouflon population of Cyprus (Ovis orientalis ophion) comprises historically preserved feral descendants of sheep
domesticated during the Neolithic. We determined genetic identity of this taxon in order to elucidate its systematic
placement and enforce its protection. We used 12 loci of microsatellite DNA to infer genetic relationships between the
Cypriot mouflon and either long-time isolated (Corsica, Sardinia) or recently introduced (central Italy) European mouflons
(O. o. musimon). We also sequenced the mitochondrial DNA (mtDNA) Cytochrome-b gene to infer the origin of the
Cypriot mouflon including many National Centre for Biotechnology Information (NCBI) entries of European and Near
Eastern conspecifics. Microsatellites disclosed net divergence between Western Mediterranean and Cypriot mouflon. The
latter was included in the highly heterogeneous Near Eastern O. orientalis mtDNA group, Iran representing the most
credited region as the source for its ancient introduction to Cyprus. Both international and national legislation protect the
mouflon of Cyprus as a wild taxon (O. o. ophion). However, the IUCN Red List of Threatened Species and NCBI include
the Cypriot mouflon as subspecies of its respective domestic species, the sheep (O. aries). Unfortunately, people charged
with crime against protected mouflon may benefit from such taxonomic inconsistency between legislation and databases, as
the latter can frustrate molecular DNA forensic outcomes. Until a definitive light can be shed on Near Eastern O. orientalis
systematics, we suggest that the Cypriot mouflon should be unvaryingly referred to as O. o. ophion in order not to impair
conservation in the country where it resides
A FORMAĂĂO NO TEMPO E NO ESPAĂO DA INTERNET DAS COISAS
RESUMO: A Internet das Coisas tem revolucionado a forma de produção e reprodução do conhecimento. Trata-se de um tipo de interface comunicacional entre humanos, mĂĄquinas e objetos que, ao fundir os mundos material e informacional, suscita as seguintes questĂ”es: (1) a possibilidade de obtenção imediata de quaisquer informaçÔes implicaria na produção do pensamento crĂtico, em uma espĂ©cie de relação causa-efeito?; (2) se Ă© possĂvel acessar as informaçÔes em quaisquer tempo e espaço, quais seriam as transformaçÔes decorrentes no processo formativo dos alunos e dos professores? Justamente essas questĂ”es motivaram os autores do artigo a elaborar o seguinte objetivo: refletir criticamente sobre a revitalização do conceito de formação (Bildung ) na temporalidade e localidade da Internet das Coisas