Lodz City Tour: The Changing Nature of the Urban Restructuring of a Post-Socialist Industrial City

This paper describes the restructuring of Poland’s third-largest city, Lodz (Łódź). Once a thriving metropolitan hub of textile and clothing manufacturing, Lodz was confronted with the closure of its numerous factories in the early 1990s with Poland’s transition from a planned to a global market economy. The city suffered an abrupt and dramatic decline followed by a redefinition of its economic, spatial and social structures. The paper focuses on the major economic and spatial phenomena taking place in the city in the three decades after the economic collapse. Using an evolutionary approach, it identifies and discusses the gradual shift of Lodz’s restructuring. We claim that the restructuring initially involved mostly organic and spontaneous initiatives of dynamic local and non-local actors, with minor and circumstantial involvement from the local authorities. However, over time, the restructuring of Lodz has become influenced and driven by nationally and EU-set objectives and targeted urban policies, with urban and infrastructural projects as driving vehicles.Jakub Zasina’s portion of this work was supported by the National Science Centre in Poland (grant agreement no. 2016/23/N/HS4/03390)

Real-world study of children and young adults with myeloproliferative neoplasms: identifying risks and unmet needs

Myeloproliferative neoplasms (MPNs) are uncommon in children/young adults. Here, we present data on unselected patients diagnosed before 25 years of age included from 38 centers in 15 countries. Sequential patients were included. We identified 444 patients, with median follow-up 9.7 years (0-47.8). Forty-nine (11.1%) had a history of thrombosis at diagnosis, 49 new thrombotic events were recorded (1.16% patient per year [pt/y]), perihepatic vein thromboses were most frequent (47.6% venous events), and logistic regression identified JAK2V617F mutation (P = .016) and hyperviscosity symptoms (visual disturbances, dizziness, vertigo, headache) as risk factors (P = .040). New hemorrhagic events occurred in 44 patients (9.9%, 1.04% pt/y). Disease transformation occurred in 48 patients (10.9%, 1.13% pt/y), usually to myelofibrosis (7.5%) with splenomegaly as a novel risk factor for transformation in essential thrombocythemia (ET) (P= .000) in logistical regression. Eight deaths (1.8%) were recorded, 3 after allogeneic stem cell transplantation. Concerning conventional risk scores: International Prognostic Score for Essential Thrombocythemia-Thrombosis and new International Prognostic Score for Essential Thrombocythemia-Thrombosis differentiated ET patients in terms of thrombotic risk. Both scores identified high-risk patients with the same median thrombosis-free survival of 28.5 years. No contemporary scores were able to predict survival for young ET or polycythemia vera patients. Our data represents the largest real-world study of MPN patients age < 25 years at diagnosis. Rates of thrombotic events and transformation were higher than expected compared with the previous literature. Our study provides new and reliable information as a basis for prospective studies, trials, and development of harmonized international guidelines for the specific management of young patients with MPN

Karst map of Georgia (Caucasus region) scale: 1:1,500,000

Karst landscapes develop in soluble rocks, such as carbonates and evaporates, but also in various types of rocks that develop pseudokarst features. The main aim of this work is to introduce a new karst map of Georgia (scale: 1:1,500,000) presenting karst and pseudokarst features, which occupy about 17.9% (12,454 km2) of the entire territory of the country and include over 1500 known caves. We distinguish two types of karst features—karst (developed in carbonate rocks) and pseudokarst, and also five subtypes, mainly based on their lithology. About 10.2% (7120 km2) of the country is occupied by karst (carbonate rocks), and about 7.7% (5334 km2) of the country is occupied by pseudokarst features. This karst map of Georgia will provide important assistance to local and foreign researchers interested in studying Georgian karst features