Discovery of prognostic biomarker candidates of lacunar infarction by quantitative proteomics of microvesicles enriched plasma

10.1371/journal.pone.0094663PLoS ONE94e9466

Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe

10.1039/c1cc14824aChemical Communications474011306-11308CHCO

Temporal lobe proteins implicated in synaptic failure exhibit differential expression and deamidation in vascular dementia

10.1016/j.neuint.2014.12.002Neurochemistry International8087-9

Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial amyotrophic lateral sclerosis

10.1016/j.neulet.2016.05.006Neuroscience Letters62447-5

Role of exosomes in cancer-related cognitive impairment

10.3390/ijms21082755International Journal of Molecular Sciences218275

Ginkgotides: Proline-rich hevein-like peptides from gymnosperm Ginkgo biloba

10.3389/fpls.2016.01639Frontiers in Plant Science742675163

Supplementary Material for: Brain-Site-Specific Proteome Changes Induced by Neuronal P60TRP Expression

p60 transcription regulator protein (p60TRP) facilitates the processing of the amyloid precursor protein towards the non-amyloidogenic pathway by inhibiting the β-secretase action. This protein was initially identified to be downregulated in the temporal lobe of brains from Alzheimer's disease patients. p60TRP is one of the G-protein-coupled receptor (GPCR)-associated proteins which directly influences the signalling capacity of GPCRs. In the present study, we investigated the brain-region-specific proteome profile of transgenic p60TRP mice to gain an insight into the molecular events mediated by the long-term effect of neuronal p60TRP overexpression on brain proteome changes and its potential implication for neuronal functions in the central nervous system. Using a proteomics research approach based on isobaric tags for relative and absolute quantitation, we identified 2,025 proteins, whereby 1,735 proteins were quantified, out of which 56 were found to be significantly altered in the cortex and/or hippocampus of neuronal transgenic neuronal p60TRP mice. Our data suggests that in vivo overexpression of neuronal p60TRP significantly affects cognitive and neuroprotective capacities

Serum albumin cysteine trioxidation is a potential oxidative stress biomarker of type 2 diabetes mellitus

10.1038/s41598-020-62341-zScientific Reports10