Amplified spontaneous emission in short-pulse excimer amplifiers.

We have found a simple analytical expression which describes the relation between amplified spontaneous emission (ASE) and small-signal gain in short-pulse amplifiers. It is also shown that the contrast of the short pulse to the ASE is weakly dependent on the saturation of the ASE, and influenced mainly by the saturation of the short pulse. The theoretical considerations were verified by measurements

Widespread abiotic methane in chromitites

Recurring discoveries of abiotic methane in gas seeps and springs in ophiolites and peridotite massifs worldwide raised the question of where, in which rocks, methane was generated. Answers will impact the theories on life origin related to serpentinization of ultramafic rocks, and the origin of methane on rocky planets. Here we document, through molecular and isotopic analyses of gas liberated by rock crushing, that among the several mafic and ultramafic rocks composing classic ophiolites in Greece, i.e., serpentinite, peridotite, chromitite, gabbro, rodingite and basalt, only chromitites, characterized by high concentrations of chromium and ruthenium, host considerable amounts of 13C-enriched methane, hydrogen and heavier hydrocarbons with inverse isotopic trend, which is typical of abiotic gas origin. Raman analyses are consistent with methane being occluded in widespread microfractures and porous serpentine- or chlorite-filled veins. Chromium and ruthenium may be key metal catalysts for methane production via Sabatier reaction. Chromitites may represent source rocks of abiotic methane on Earth and, potentially, on Mars

Feasibility of a laboratory X-ray laser pumped by ultrashort UV laser pulses.

In order to allow widespread application of soft X-ray lasers there is a strong effort worldwide to use as small as possible pump lasers for plasma production. Short pulse lasers (τ ≈ 1 ps), particularly in the UV, have attracted much interest, since extremely high intensities (up to 1018 W/cm2) can be achieved with a relatively high repetition rate. In this article we discuss their merit for soft X-ray laser pumping and possible solutions to the specific problems, for instance pulse front distortion, nonlinear absorption in window materials, plasma formation by short laser pulses and the relatively low total pump energy

Absorption of femtosecond laser pulses in high-density plasma.

The absorption of 250-fs KrF laser pulses incident on solid targets of aluminum and gold has been measured as a function of polarization and angle of incidence for the intensity range of 1014–2.5×1015 W cm−2. Maximum absorption of over 60% occurs for p-polarized radiation at angles of incidence in the range of 48°–57°. The measured results are in agreement with absorption on a steep density gradient

Evaluating Lifeworld as an emancipatory methodology

Disability research is conducted within a highly politicised ‘hotbed’ of competing paradigms and principles. New researchers, who want to work within the social model, are soon faced with complex and challenging methodological and philosophical dilemmas. The social model advocates research agendas that are focused on the emancipation and empowerment of disabled people but, in reality, these are rarely achieved. To be successful researchers need to engage with innovative and creative methodologies and to share their experiences of these within environments that welcome challenge and debate. This paper focuses on Lifeworld and assesses its value as a tool for emancipatory research. Using examples from a study with parents, whose children were in the process of being labelled as having autism, the paper illustrates how the principles that ‘underpin’ the methodology offered a supportive framework for a novice researcher

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study - A Randomized Clinical Trial

Background: Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on dogs before the onset of CHF is unknown. Hypothesis/Objectives: Administration of pimobendan (0.4-0.6 mg/kg/d in divided doses) to dogs with increased heart size secondary to preclinical MMVD, not receiving other cardiovascular medications, will delay the onset of signs of CHF, cardiac-related death, or euthanasia. Animals: 360 client-owned dogs with MMVD with left atrial-to-aortic ratio >= 1.6, normalized left ventricular internal diameter in diastole >= 1.7, and vertebral heart sum >10.5. Methods: Prospective, randomized, placebo-controlled, blinded, multicenter clinical trial. Primary outcome variable was time to a composite of the onset of CHF, cardiac-related death, or euthanasia. Results: Median time to primary endpoint was 1228 days (95% CI: 856-NA) in the pimobendan group and 766 days (95% CI: 667-875) in the placebo group (P = .0038). Hazard ratio for the pimobendan group was 0.64 (95% CI: 0.47-0.87) compared with the placebo group. The benefit persisted after adjustment for other variables. Adverse events were not different between treatment groups. Dogs in the pimobendan group lived longer (median survival time was 1059 days (95% CI: 952-NA) in the pimobendan group and 902 days (95% CI: 747-1061) in the placebo group) (P = .012). Conclusions and Clinical Importance: Administration of pimobendan to dogs with MMVD and echocardiographic and radiographic evidence of cardiomegaly results in prolongation of preclinical period and is safe and well tolerated. Prolongation of preclinical period by approximately 15 months represents substantial clinical benefit

Great Successes and Great Failures: The Impact of Project Leader Status on Project Performance and Performance Extremeness

Research supporting the Matthew effect demonstrates that high-status actors experience performance benefits due to increased recognition of their work and greater opportunities and resources, but recent research also indicates that high-status actors face a greater risk of negative performance evaluations. In this paper, we seek to contribute to the status literature by reconciling these findings and ask: To what extent does status influence heterogeneity in performance evaluations? We explore how project leader status affects the performance of innovation projects in the video game industry. We hypothesize that there is an inverted U-shaped relationship between project leader status and project performance, and a positive relationship between project leader status and performance extremeness (i.e., performance variation). In order to test our hypotheses, we analysed the performance of video game projects and computed the status of project leaders by applying a project affiliation social network analysis. We find that an intermediate level of status – neither too much nor too little – is positively associated with average project performance. We also reveal more extreme performance effects for high-status leaders: While some achieve superior project performance, others experience significant project failures. We, therefore, provide important theoretical and practical insights regarding how status affects the implementation of innovations. We also discuss the implications of these findings for the literature on middle-status conformity

Large-scale associations between the leukocyte transcriptome and BOLD responses to speech differ in autism early language outcome subtypes.

Heterogeneity in early language development in autism spectrum disorder (ASD) is clinically important and may reflect neurobiologically distinct subtypes. Here, we identified a large-scale association between multiple coordinated blood leukocyte gene coexpression modules and the multivariate functional neuroimaging (fMRI) response to speech. Gene coexpression modules associated with the multivariate fMRI response to speech were different for all pairwise comparisons between typically developing toddlers and toddlers with ASD and poor versus good early language outcome. Associated coexpression modules were enriched in genes that are broadly expressed in the brain and many other tissues. These coexpression modules were also enriched in ASD-associated, prenatal, human-specific, and language-relevant genes. This work highlights distinctive neurobiology in ASD subtypes with different early language outcomes that is present well before such outcomes are known. Associations between neuroimaging measures and gene expression levels in blood leukocytes may offer a unique in vivo window into identifying brain-relevant molecular mechanisms in ASD