6 research outputs found
Preferential Myosin Heavy Chain Isoform B Expression May Contribute to the Faster Velocity of Contraction in Veins versus Arteries
- Author
- Publication venue
- e-Publications@Marquette
- Publication date
- 01/06/2007
- Field of study
Get PDFSmooth muscle myosin heavy chains occur in 2 isoforms, SMA (slow) and SMB (fast). We hypothesized that the SMB isoform is predominant in the faster-contracting rat vena cava compared to thoracic aorta. We compared the time to half maximal contraction in response to a maximal concentration of endothelin-1 (ET-1; 100 nM), potassium chloride (KCl; 100 mM) and norepinephrine (NE; 10 µM). The time to half maximal contraction was shorter in the vena cava compared to aorta (aorta: ET-1 = 235.8 ± 13.8 s, KCl = 140.0 ± 33.3 s, NE = 19.8 ± 2.7 s; vena cava: ET-1 = 121.8 ± 15.6 s, KCl = 49.5 ± 6.7 s, NE = 9.0 ± 3.3 s). Reverse-transcription polymerase chain reaction supported the greater expression of SMB in the vena cava compared to aorta. SMB was expressed to a greater extent than SMA in the vessel wall of the vena cava. Western analysis determined that expression of SMB, relative to total smooth muscle myosin heavy chains, was 12.5 ± 4.9-fold higher in the vena cava compared to aorta, while SMA was 4.9 ± 1.2-fold higher in the aorta than vena cava. Thus, the SMB isoform is the predominant form expressed in rat veins, providing one possible mechanism for the faster response of veins to vasoconstrictors
Preferential Myosin Heavy Chain Isoform B Expression May Contribute to the Faster Velocity of Contraction in Veins versus Arteries
- Author
- Anas Kayal
- Arner A
- Arthur S. Rovner
- Catherine M. Rondelli
- DiSanto ME
- Eddinger T
- Eddinger T
- Eddinger T
- Florian J
- Gregory D. Fink
- Hamada Y
- Heaps C
- Hottenstien OD
- Irina T. Szasz
- Karagiannis P
- Kelly C
- Keshari Thakali
- Kreulen DL
- Low R
- Meer D
- Mutuchamy M
- Nagai R
- Nagai R
- Northcott C
- Ogut O
- Patzak A
- Ralph E. Watson
- Rovner AS
- Sellers JR
- Sherwood J
- Shiraishi M
- Stephanie W. Watts
- Tanaka Y
- Thakali K
- Thomas J. Eddinger
- Varma DR
- White S
- White S
- Zhang W
- Zhong H
- Publication venue
- 'S. Karger AG'
- Publication date
- Field of study
No full textRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
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- Field of study
No full textBackground: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Methods: NAVIGATE ESUS was a double-blinded, randomised, phase 3 trial done at 459 centres in 31 countries that assessed the efficacy and safety of rivaroxaban versus aspirin for secondary stroke prevention in patients with ESUS. For this prespecified subgroup analysis, cohorts with and without PFO were defined on the basis of transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE). The primary efficacy outcome was time to recurrent ischaemic stroke between treatment groups. The primary safety outcome was major bleeding, according to the criteria of the International Society of Thrombosis and Haemostasis. The primary analyses were based on the intention-to-treat population. Additionally, we did a systematic review and random-effects meta-analysis of studies in which patients with cryptogenic stroke and PFO were randomly assigned to receive anticoagulant or antiplatelet therapy. Findings: Between Dec 23, 2014, and Sept 20, 2017, 7213 participants were enrolled and assigned to receive rivaroxaban (n=3609) or aspirin (n=3604). Patients were followed up for a mean of 11 months because of early trial termination. PFO was reported as present in 534 (7·4%) patients on the basis of either TTE or TOE. Patients with PFO assigned to receive aspirin had a recurrent ischaemic stroke rate of 4·8 events per 100 person-years compared with 2·6 events per 100 person-years in those treated with rivaroxaban. Among patients with known PFO, there was insufficient evidence to support a difference in risk of recurrent ischaemic stroke between rivaroxaban and aspirin (hazard ratio [HR] 0·54; 95% CI 0·22–1·36), and the risk was similar for those without known PFO (1·06; 0·84–1·33; pinteraction=0·18). The risks of major bleeding with rivaroxaban versus aspirin were similar in patients with PFO detected (HR 2·05; 95% CI 0·51–8·18) and in those without PFO detected (HR 2·82; 95% CI 1·69–4·70; pinteraction=0·68). The random-effects meta-analysis combined data from NAVIGATE ESUS with data from two previous trials (PICSS and CLOSE) and yielded a summary odds ratio of 0·48 (95% CI 0·24–0·96; p=0·04) for ischaemic stroke in favour of anticoagulation, without evidence of heterogeneity. Interpretation: Among patients with ESUS who have PFO, anticoagulation might reduce the risk of recurrent stroke by about half, although substantial imprecision remains. Dedicated trials of anticoagulation versus antiplatelet therapy or PFO closure, or both, are warranted. Funding: Bayer and Janssen
Cancer-type dependent expression of CK2 transcripts
- Author
- A Andersson
- A Deshiere
- A Rosenwald
- A Rosenwald
- A Sengupta
- A Silva
- AA Alizadeh
- AA Kramerov
- AC Bibby
- AI Riker
- AM Gomes
- AM Szasz
- B Chen
- B Guerra
- B Guerra
- B Gyorffy
- B Zhou
- BJ Quade
- C Cutcliffe
- C Guo
- C Haqq
- C Haslinger
- C Morrison
- C Posch
- C Roelants
- C Song
- CE Ortega
- CH Peng
- CM Cannon
- D Dixit
- D Hanahan
- D Pyeon
- D Talantov
- DA Canton
- DC Seldin
- DC Seldin
- DC Seldin
- DK Jeppesen
- DR Rhodes
- DW Litchfield
- DW Litchfield
- DW Litchfield
- DY Lou
- E Coustan-Smith
- E Landesman-Bollag
- E Wurmbach
- ET Kimchi
- F Zhan
- FA Piazza
- FJ Lozeman
- G Cozza
- G Maridor
- G Stalter
- GJ Gordon
- H He
- H Jiang
- HS Kim
- HX Zhang
- I Dominguez
- Irina V. Lebedeva
- Isabel Dominguez
- J Barretina
- J Jones
- J Ladha
- J Lee
- JA Ludwig
- JE Korkola
- JH Trembley
- JH Trembley
- JM Sperger
- JS Bae
- JS Kim
- JY Cho
- K Ahmed
- K Ahmed
- K Basso
- K Oshida
- K Shimada
- K Stegmaier
- K Takahashi
- KA Ahmad
- KE Deffenbacher
- KY Detwiller
- KY Lin
- L Agnelli
- L Dyrskjot
- L Ferrer-Font
- L Quotti Tubi
- L Sun
- LA Pinna
- LR Martins
- M Bredel
- M Compagno
- M D'Errico
- M Gapany
- M Guo
- M Pizzi
- M Rabjerg
- M Rabjerg
- M Ruzzene
- M Sanchez-Carbayo
- Melissa M. J. Chua
- Migi Lee
- MM Chua
- MN Storz
- MS Brown
- MS Hung
- MV Yusenko
- N Bilous
- N Dubois
- N Goossens
- N Pencheva
- OA Timofeeva
- OD Filhol
- P Channavajhala
- P Massimi
- P O-charoenrat
- PJ French
- PP Piccaluga
- R Krick
- R Shai
- RA Faust
- RA Faust
- RI Skotheim
- RT Nitta
- S Eckerle
- S Maia
- S Manni
- S Michiels
- S Roessler
- S Tawfic
- S Tugizov
- S Wang
- S Zhang
- SE Choi
- SG Talbot
- SM Kim
- T Haferlach
- T Mandal
- U Wirkner
- V Brune
- V Pascual
- X Bai
- X Chen
- X Chen
- X Peng
- X Xu
- X Zhang
- Y Bian
- Y Hao
- Y Zheng
- YF Liu
- YL Choi
- YS Lee
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
No full textRivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
- Author
- A Adami
- A Ali
- A Amelia Pinto
- A Arauz
- A Bacellar
- A Balazs
- A Baranowska
- A Barulin
- A Beinlich
- A Belkin
- A Benjamin
- A Cavallini
- A Chakrabarti
- A Chamorro
- A Corlobe
- A Csanyi
- A Czlonkowska
- A Daineko
- A Danese
- A De Havenon
- A De Pauw
- A De Smedt
- A Del Giudice
- A Dávalos
- A Favate
- A Fedin
- A Ferreira
- A Filipov
- A Firstenfeld
- A Fraczek
- A Friedman
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- A Garcia Pastor
- A Gil Nunez
- A Glabinski
- A Gomes Neto
- A Gueguen
- A Hajas
- A Hassan
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- A Horev
- A Irina Aniculaesei
- A Jagolino
- A Jun-Oconnell
- A Katalin Iljicsov
- A Kei
- A Khanna
- A Khaw
- A Kobayashi
- A Koutroubi
- A Kulakowska
- A Kuris
- A Lago
- A Landolfi
- A Lasek-Bal
- A Leger
- A Lindgren
- A Lord
- A Lvova
- A Mackey
- A Magadan
- A Mahagney
- A Majid
- A Majjhoo
- A Maria Lorenzo
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- A Maud
- A Mayr
- A Mensch
- A Mismas
- A Mistri
- A Moey
- A Molis
- A Morales
- A Mowla
- A Murtuzova
- A Nave
- A Obrezan
- A Odyniec
- A Papagiannis
- A Penn
- A Persico
- A Pidal
- A Pieroni
- A Polyakov
- A Polymeris
- A Poppe
- A Radtke
- A Rani
- A Rasheed Nihara
- A Renu
- A Rocco
- A Rodriguez Campello
- A Roldan
- A Ruiz Franco
- A Sabet
- A Sarraj
- A Sas
- A Semerano
- A Sharrief
- A Shmonin
- A Shoamanesh
- A Shuaib
- A Shulga
- A Simpkins
- A Smolkin
- A Smyth
- A Sobota
- A Stoll
- A Stumpp
- A Szekely
- A Tamayo
- A Tapanainen
- A Tayal
- A Terentiou
- A Thomson
- A Tinchon
- A Tountopoulou
- A Trommer
- A Tutaj
- A Valikovics
- A Vasco Salgado
- A Vila
- A Wach-Klink
- A Wacongne
- A Winkler
- A Winska-Tereszkiewicz
- A Wisniewska
- A Wlodek
- A Wojnarowska-Arendt
- A Wong
- A Ximenez-Carrillo
- A Yongwon Jin
- A Zitzmann
- AA Arauz Gongora
- AA Silva
- AB Constantino Silva
- AK Amjad
- AM Iglesias Mohedano
- Anderson
- Arne Lindgren
- Ashkan Shoamanesh
- B Blazejewska-Hyzorek
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- DC Anderson
- DG Wyse
- DI Chang
- Di Tullio
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- E Anagnostou
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- E Pepper
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- E Österlund-Tauriala
- EM Baez Martinez
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No full textCardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
- Dalia Jarasuniene
- Dallas Price
- Dalton McLean
- Daniel Aradi
- Daniel Beug
- Daniel Fisher
- Daniel Gaudet
- Daniel Lenihan
- Daniel Lighezan
- Daniel Pauly
- Daniel Savard
- Daniel Vogel
- Daniela Garcia Brasca
- Daniela Pini
- Daniela Vinanska
- Dariusz Korczyk
- David Chang
- David F Kong
- David Henderson
- David Lanfear
- David Murray
- David Rawitscher
- David Schultz
- David Stepek
- David Whellan
- Debashis Roy
- Deddo Moertl
- Denis-Carl Phaneuf
- Dennis Rupka
- Deovrat Singh
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- Vyacheslav Mareev
- Vyacheslav Ryabov
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- Weimin Li
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- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
No full textBACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)
