32 research outputs found
NĂ©hĂĄny fĂ©m-organikus vegyĂŒlet molekulĂĄris mĂĄgnessĂ©gĂ©nek vizsgĂĄlata Mössbauer-spektroszkĂłpiĂĄval
2-es tĂpusĂș diabetes mellitus, inzulinrezisztencia Ă©s mĂĄjrĂĄk idĂŒlt hepatitis C-fertĆzĂ©sben. Ăszakkelet-magyarorszĂĄgi adatok = Type 2 diabetes mellitus, insulin resistance and hepatocellular carcinoma in chronic hepatitis C patients Data from Northeastern Hungary
Absztrakt:
BevezetĂ©s: Az idĂŒlt hepatitis C-vĂrus (HCV)-fertĆzĂ©s gyakori
szövĆdmĂ©nyei a mĂĄjzsugor (20â25%) Ă©s a mĂĄjrĂĄk (1,5â3%), valamint az
inzulinrezisztencia (30â40%) Ă©s a 2-es tĂpusĂș diabetes mellitus (25â30%); az
utĂłbbiakrĂłl kevĂ©s magyar adat Ă©rhetĆ el. CĂ©lkitƱzĂ©s: A kĂłrkĂ©pek
gyakorisĂĄgĂĄt, az interferonalapĂș terĂĄpiĂĄval kapcsolatos metabolikus vĂĄltozĂĄsokat
Ă©s a virolĂłgiai vĂĄlaszkĂ©szsĂ©get Ă©rtĂ©keltĂŒk magyar betegekben, akiket tartĂłsan
követtĂŒnk a mĂĄjrĂĄk korai felismerĂ©sĂ©re. MĂłdszer:
VizsgĂĄlatunkban 150 HCV-beteg (ĂĄtlagĂ©letkor: 48,55 ± 8,55 Ă©v, fĂ©rfi/nĆ: 45/55%)
kezelĂ©s elĆtti, alatti Ă©s utĂĄni adatait elemeztĂŒk, majd 5 Ă©ves követĂ©st
vĂ©geztĂŒnk (2012â2017). EredmĂ©nyek: A vizsgĂĄlatba bevont betegek
35,3%-a inzulinrezisztensnek, mĂg 27,3%-a diabetesesnek bizonyult; e kĂ©t
vizsgålati alcsoportban a vérmintåk levételének napjån a kiindulåsihoz képest
szignifikĂĄnsan csökkent Ă©hgyomri vĂ©rcukorĂ©rtĂ©kek mutatkoztak a kezelĂ©st követĆen
fél évvel (5,47 ± 0,66 vs. 5,08 ± 0,60, p<0,001; 7,90 ± 2,67 vs. 7,04 ± 2,75,
p = 0,006). ĂszlelĂ©sĂŒnk fĂŒggetlen volt az antivirĂĄlis kezelĂ©s sikerĂ©tĆl, mely a
cukorbetegekben jelentĆsen kisebbnek bizonyult az inzulinszenzitĂv Ă©s az
inzulinrezisztens csoportĂ©tĂłl (17% vs. 46% Ă©s 40%). A tartĂłs vĂrusmentessĂ©g
elĂ©rĂ©sĂ©ben nem volt elĆny az inzulinszenzitivitĂĄs. Az 5 Ă©ves követĂ©s alatt hĂĄrom
cukorbetegben jelent meg måjråk, amelyek felismerése rendszeres
ultrahang-szƱrĆvizsgĂĄlat rĂ©vĂ©n törtĂ©nt. KövetkeztetĂ©s: Az
inzulinrezisztencia Ă©s a 2-es tĂpusĂș diabetes az irodalmi adatokkal egyezĆen
gyakori volt idĂŒlt HCV-fertĆzött betegeinkben. Az antivirĂĄlis kezelĂ©s kedvezĆ
szĂ©nhidrĂĄtanyagcsere-vĂĄltozĂĄsokat eredmĂ©nyezett. Adataink megerĆsĂtik, hogy a
korai mĂĄjrĂĄk felfedezĂ©sĂ©re a mĂĄjzsugorban Ă©s cukorbetegsĂ©gben szenvedĆ
HCV-betegekben is fĂ©lĂ©venkĂ©nt hasi ultrahangvizsgĂĄlat vĂ©gzĂ©se szĂŒksĂ©ges. Orv
Hetil. 2019; 160(40): 1591â1602.
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Abstract:
Introduction: Liver cirrhosis (20â25%), hepatocellular carcinoma
(1.5â3%), insulin resistance (30â40%) and type 2 diabetes (25â30%) are common
complications in patients with chronic hepatitis C virus (HCV) infection;
however, data are missing from Hungary. Aim: To determine the
prevalence of diabetes and insulin resistance in Hungarian HCV patients; to
evaluate treatment-induced metabolic changes in relation to diabetes/insulin
resistance and virological response and to perform a sustained follow-up for
hepatocellular carcinoma detection. Method: We enrolled 150
Hungarian HCV genotype 1 patients (mean age: 48.55 ± 8.55 years, male/female
ratio: 45/55%) from 2007â2012. We analysed their baseline, week 12, and end of
therapeutic follow-up (24 weeks after interferon-based therapy completion)
laboratory data. We performed a 5-year follow-up (2012â2017).
Results: The prevalence of insulin sensitivity, insulin
resistance and diabetes was 37.4%, 35.3% and 27.3%, respectively. Insulin
resistant and diabetic patients showed a decrease in fasting glucose from
baseline to end of follow-up (5.47 ± 0.66 vs. 5.08 ± 0.60, p<0.001; 7.90 ±
2.67 vs. 7.04 ± 2.75, p = 0.006), as did both the sustained responder and
non-responder groups. Treatment efficacy rate was poor in diabetic vs. insulin
sensitive and insulin resistant groups (17% vs. 46% and 40%); insulin
sensitivity was not a predictor of virological response. Three participants with
diabetes were diagnosed with hepatocellular carcinoma during follow-up by
regular ultrasound examinations. Conclusion: Hungarian HCV
patients showed high prevalence of diabetes and insulin resistance, though
antiviral therapy caused favourable changes in their carbohydrate metabolism.
Antiviral therapy was less effective in diabetic patients. Follow-up ultrasound
examinations are required for hepatocellular carcinoma in HCV patients,
especially those with diabetes. Orv Hetil. 2019; 160(40): 1591â1602
Synthesis, physico-chemical characterization and bacteriostatic study of Pt complexes with substituted amine ligands
Three complexes of general formula PtCl2R2 were synthesized, where R is the amine ligand with aromatic substituents. Coordination compounds [Pt(an)2Cl2] (1), [Pt(pa)2Cl2] (2) and [Pt(aph)2Cl2] (3), where an = 2-aminonaphthalene, pa = 2-aminopyrimidine, aph = 4-anilinophenol, were characterized by on-line coupled TG/DTA-MS, powder XRD and spectroscopic techniques (FTIR, ESIâMS and NMR), and tested against selected Gram(+) and Gram(â) bacteria. The thermal data show that all three compounds contain lattice or absorbed water, and the stability of the anhydrous compounds in nitrogen decreases in the order 2 > 1 > 3. Above 200 °C, the complexes loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples and prove their composition. The compounds are more effective inhibitors of Gram(+) than Gram(â) bacteria. © 2016 AkadĂ©miai KiadĂł, Budapest, Hungar
Total synthesis of isotopically enriched Si-29 silica NPs as potential spikes for isotope dilution quantification of natural silica NPs
A new method was developed for the preparation of highly monodisperse isotopically enriched Si-29 silica nanoparticles (29Si-silica NPs) with the purpose of using them as spikes for isotope dilution mass spectrometry (IDMS) quantification of silica NPs with natural isotopic distribution. Si-29 tetraethyl orthosilicate (29Si-TEOS), the silica precursor was prepared in two steps starting from elementary silicon-29 pellets. In the first step Si-29 silicon tetrachloride (29SiCl4) was prepared by heating elementary silicon-29 in chlorine gas stream. By using a multistep cooling system and the dilution of the volatile and moisture-sensitive 29SiCl4 in carbon tetrachloride as inert medium we managed to reduce product loss caused by evaporation. 29Si-TEOS was obtained by treating 29SiCl4 with absolute ethanol. Structural characterisation of 29Si-TEOS was performed by using 1H and 13C nuclear magnetic resonance (NMR) spectroscopy and Fourier-transform infrared (FTIR) spectroscopy. For the NP preparation, a basic amino acid catalysis route was used and the resulting NPs were analysed using transmission electron microscopy (TEM), small angle X-ray scattering (SAXS), dynamic light scattering (DLS) and zeta potential measurements. Finally, the feasibility of using enriched NPs for on-line field-flow fractionation coupled with multi-angle light scattering and inductively coupled plasma mass spectrometry (FFF/MALS/ICP-MS) has been demonstrated
Schiff-båzisokkal képzett vas(II)-komplexek szintézise, fizikaikémiai és biológiai aktivitåsuk vizsgålata = Synthesis of Fe(II)-complexes with Schiff bases, physical chemical and biological activity study
Novel cobalt complexes with glyoximes : synthesis, physicochemical analysis and biological study
Azomethine derivatives have several applications, especially as reagents for the determination of transition metal ions. Furthermore these ligands and their cobalt complexes were also reported to possess biological activities, such as antimicrobial, anti-tubercular, anticonvulsant, anti-inflammatory, anti-proliferative activities as well as antifungal inhibition potential [1]. Another reason for using metal-containing compounds as structural scaffolds is related to the kinetic stability of their coordination spheres in the biological environment. Metallic ions have been shown to play important role in the biological activity of different compounds in such away that, in some cases, activity is enhanced or only takes place in the presence of these ions [2]. In our research new cobalt(III) complexes were synthesized with -glyoximes, azides, amines, thiocyanate and halogens, such as [Co(Me-propyl-GlyoxH)2(N3)(amine)], [Co(Mepentyl-GlyoxH)2(N3)(amine)], [Co(Et-propyl-GlyoxH)2(N3)(amine)], [Co(Et-propylGlyoxH)2(Br)(amine)], [Co(Et-propyl-GlyoxH)2(SCN)(amine)], H[Co(Et-propylGlyoxH)2(SCN)2], [Co(phenyl-Me-GlyoxH)2(amine)2]I, [Co(Et-propyl-GlyoxH)2(amine)2]I, [Co(Et-Bu-GlyoxH)2(amine)2]I, where GlyoxH = mono deprotonated glyoxime, and the used amines: imidazole, 3-hydroxy-aniline, lepidine, 3,5-dimethyl-pyridine, di(n-butyl)-amine, diisopropyl-amine, 2-amino-pyrimidine, diphenyl-amine, 2-picoline, 3-picoline. The Co(II)- acetate salt dissolved in water and mixed with the glyoxime alcoholic solution was oxidized by air bubbling, then the corresponding diamines and the other complexing agents were added. The molecular structure of our products was investigated by IR, UVâVIS spectroscopy, mass spectrometry (MS), thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity, like antimicrobial effect, was studied for a few bacteria
Considering PKI Safety Impact on Network Performance During V2X-based AD/ADAS Function Development Processes
In this research, we examine the impact of PKI on vehicle safety and thus make suggestions for further improvements to V2X-based safety application design processes. In the first step, we introduce the novel methodological background of characterizing the safety impact of the network performance metrics on the V2X-based automotive applications. Following this, we investigated two cases: with and without Public Key Infrastructure (PKI) authorization, to identify the potential safety effect if the V2X device is unprepared for the additional computational overhead caused by the authentication framework-related processes. Based on our results, we can identify the operational domain of a specific V2X-based application that can be used safely
Novel platinum complexes with schiff bases and α-Dioximes, their physico-chemical and biological study
In our research project we prepared the following platinum(II) complexes with Schiff bases and -dioximes, such as [Pt(ketone)2A(L2)], (ketone: 2-heptanone, 2-octanone, 3-octanone; A: hydrazine, phenylhydrazine, o-phenylene-diamine; L: 1-naphthylamine, 2-aminopyrimidine, 2-methylimidazole, 2-amino-4-methylpyridine) and [Pt(DioxH)2L2], (DioxH2: methyl-phenyl-dioxime, butyl-methyl-dioxime; L: 1-naphthylamine, 2-methylimidazole, 2-amino-4-methylpyridine, lepidine, 2-methylpyridine, m-toluidine, dicyclohexylamine, 4-isopropylamine, cyclohexylamine), by the reaction of PtCl2 in suitable solvent. After a short bibliographical survey, involving the classification and evolution of platinum complexes with possible applications, we analyzed their physico-chemical properties using FTIR, Raman, NMR, UV-VIS spectroscopy, powder X-ray diffraction (XRD), mass spectrometry, thermal analysis (TG, DTG, DTA) and SEM. We also studied the antibacterial effect of complexes on different strains of bacteria. This class of compounds has relevance in biochemistry, some of them are antibacterial agents and potential anti-tumor drugs
Novel iron complexes with glyoximes, schiff bases and boric acid derivatives : synthesis, physico-chemical analysis and biological study
Iron(II) clathrochelate complexes obtained with glyoximes are macrobicyclic ligand systems, which completely encapsulate the metal ion, and are formed under mild conditions with high yields [1]. In particular, the riblike-functionalized clatrochelates both with the inherent and with the terminal closo-borate substituents synthesized recently have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [2]. In our research work new iron(II) complexes were synthesized with -glyoximes, boric acid derivatives, amines, Schiff bases, such as [Fe(Me-Pr-Glyox)3(BOâEt)2], [Fe(Et-BuGlyox)3(BOâR)2] (R = methyl, propyl, butyl), [Fe(phenyl-Me-GlyoxH)2(amine)2], [Fe(Et-BuGlyoxH)2(amine)2], [Fe(2-heptanone)2(en)(amine)2], where GlyoxH, Glyox = mono- or bideprotonated glyoxime, en = ethylenediamine and the used amines: dibutylamine, 3-picoline, 4-aminopyridine, 6-amino-3-picoline, 3-amino-1-propanol, imidazole, 2-aminopyrimidine, 3- methylpiperidine, 3-amino-1H-1,2,4-triazole. For preparation ironII -sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines and the other complexing agents were added. The mixture so obtained was refluxed under inert atmosphere. The molecular structures of our products were studied by IR, Mössbauer and UVâVIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). The biological activity, like antimicrobial effect, was studied for a few bacteria