Szenci Molnár kutatások - adattár, szerzői bibliográfia, egyes műveinek új kiadása = Research concerning the ouvre of Albert Szenci Molnar - bibliography of his own works and works on him, editions of his works

A kutatás első évében (2002) megkezdődött egy adattár és kézikönyvtár kialakítása, amelynek bővítése folyamatos. A pályázat keretében a témavezető időszakos kiállítást rendezett Szenci Molnár Albertről a Petőfi Irodalmi Múzeumban. A második évben digitális másolat készült a "Consecratio templi novi" című Szenci Molnár műről, s elindultak a jubileumi szótárkonferencia előkészületei. A harmadik évben megjelent az "Értekezés a legfőbb jóról" hasonmás kiadása, digitális másolat készült a "Postilla Scultetica"-ról, illetve megrendeztük a konferenciánkat a Szótár megjelenésének 400 évfordulójára, az OSZK-val közösen. A negyedik évben megindult a konferencia kötetének szerkesztése, s összeállt a Szenci Molnár-bibliográfia anyaga. | During the first year of the project we began to create a data store and a reference library concerning Szenci Molnár's ouvre; it is a continous work. Within the framework of our OTKA the person in charge of the research team arranged a Szenci Molnár exhibition in the Petőfi Literary Museum. During the second year of the project a digital copy was made of Szenci Molnár's 'Consecratio' and the jubilee conference dedicated to his Latin-Hungarian Dictionary was also prepared. During the third year the facsimile edition 'Discursus de summo bono' was published, a digital copy of the 'Postilla Scultetica' was also made ready and we celebrated the 400th anniversary of the 'Dictionary' with a conference, with the Széchényi National Library. During the 4th year we began to edit the conference volume and the material of a Szenci Molnár bibliography was also completed

The Sustainable Contribution of Artificial Intelligence to Higher Education - Results of a Pilot Study

The past year has seen revolutionary breakthroughs in the development of artificial intelligence-based (AI) products that can impact almost every aspect of life. The change raises the question of the sustainability of education and how technology will transform the way we currently teach. This study aims to develop a model and its hypothetical adaptation that can be used to analyse the adoption and use of artificial intelligence in university settings. The importance of AI in education can be captured in its ability to personalise learning pathways, improve teaching methods and automate related administrative tasks. AI technologies are able to adapt to the needs of individual learners, providing personalised instruction and improving learning outcomes. AI can also help educators by automating routine tasks, allowing them to focus on individualised instruction and create a more engaging and effective learning environment. Based on the accepted results of exploratory factor analysis as the applied method of this paper, the research concludes that the model adaptation is feasible, but it is worth considering changing the variable reflecting implementation to one that is accepted by educators as the concrete institutional implementation of AI is still a very distant scenario in higher education. Future research should incorporate these findings into the design of possible structural models, as this area of AI research has the potential to bring significant social science and educational benefits

Szenci Molnár Albert levelezése, iratai és Zsoltárkönyve = Correspondence, documents and psalter of Albert Molnár

A kutatás során közel került a befejezéshez Szenci Molnár Albert (1574-1634) levelezésének új kritikai kiadása. Beszereztük a levelek másolatát, majd elkészültek a levélszövegek, s a kommentároknak az a része, amely a korabeli európai (elsősorban németországi) viszonyokra vonatkozik. Ennek elvégzéséhez két alkalommal külföldi ösztöndíjon volt a kutatás vezetője, Szabó András és Petrőczi Éva. 2008 júliusában Wolfenbüttelben az MTA Irodalomtudományi Intézetének csereösztöndíjával, 2009 júliusában és 2010 januárjában pedig Heidelbergben a DAAD ösztöndíjával. 2007 május 24. és 27. között a két megnevezett kutató egy nemzetközi régi magyar irodalmi konferenciát rendezett Csurgón (ezen Bódiss Tamás és P. Vásárhelyi Judit is részt vett), "A zsoltár a régi magyar irodalomban" címmel. A konferencia anyagát megszerkesztettük, kiadására egyedül pénz hiányában nem került idáig sor. Szabó Andrásnak a kutatás és az előző OTKA pályázat során megjelentetett tanulmányai felhasználásával elérhető közelségbe került egy Szenci Molnár Albertről szóló monográfia megjelentetése is. | Due to our intensive research work the new critical edition of the correspondence of Albert Szenci Molnár (1574-1634) is well-prepared. We got the copies of the missing letters, the majority of the texts themselves (and their commentaries, first of all those which are referring to German settlements and characters) had already been edited, the Latin ones translated etc. The leader of the study-group got two bursaries to Germany: one to the Herzog August Bibliothek, Wofenbüttel, together with co-worker Éva Petrőczi in July 2008, with the exchange-grant of the Institute of Literary Studies of the Hungarian Academy of Sciences and another one, July 2009 and January 2010, to Heidelberg, through the DAAD. The above mentioned two scholars organized an international psaltery conference in Csurgó (24th-27th May, 2007), entitled "The Psalm in Old Hungarian Literature" with the active contribution of Judith P. Vásárhelyi and Tamás Bódiss. The written material of the conference had already been prepared and edited, only the lack of money caused some delay in its being printed. Finally, the publishing of a monograph by András Szabó, written on Albert Szenci Molnár, is also a fruit and a nearing reality of all these studies abroad and also of the two OTKA-periods dedicated to this topic

In Vivo Preclinical Assessment of β-Amyloid–Affine [11C]C-PIB Accumulation in Aluminium-Induced Alzheimer’s Disease-Resembling Hypercholesterinaemic Rat Model

Aluminum (Al) excess and hypercholesterinaemia are established risks of Alzheimer’s disease (AD). The aim of this study was to establish an AD-resembling hypercholesterinaemic animal model—with the involvement of 8 week and 48 week-old Fischer-344 rats—by Al administration for the safe and rapid verification of β-amyloid-targeted positron emission tomography (PET) radiopharmaceuticals. Measurement of lipid parameters and β-amyloid–affine [11C]C-Pittsburgh Compound B ([11C]C-PIB) PET examinations were performed. Compared with the control, the significantly elevated cholesterol and LDL levels of the rats receiving the cholesterol-rich diet support the development of hypercholesterinaemia (p ≤ 0.01). In the older cohort, a notably increased age-related radiopharmaceutical accumulation was registered compared to in the young (p ≤ 0.05; p ≤ 0.01). A monotherapy-induced slight elevation of mean standardised uptake values (SUVmean) was statistically not significant; however, adult rats administered a combined diet expressed remarkable SUVmean increment compared to the adult control (SUVmean: from 0.78 ± 0.16 to 1.99 ± 0.28). One and two months after restoration to normal diet, the cerebral [11C]C-PIB accumulation of AD-mimicking animals decreased by half and a third, respectively, to the baseline value. The proposed in vivo Al-induced AD-resembling animal system seems to be adequate for the understanding of AD neuropathology and future drug testing and radiopharmaceutical development

PET Probes for Preclinical Imaging of GRPR-Positive Prostate Cancer: Comparative Preclinical Study of [68Ga]Ga-NODAGA-AMBA and [44Sc]Sc-NODAGA-AMBA

Gastrin-releasing peptide receptors (GRPR) are overexpressed in prostate cancer (PCa). Since bombesin analogue aminobenzoic-acid (AMBA) binds to GRPR with high affinity, scandium-44 conjugated AMBA is a promising radiotracer in the PET diagnostics of GRPR positive tumors. Herein, the GRPR specificity of the newly synthetized [44Sc]Sc-NODAGA-AMBA was investigated in vitro and in vivo applying PCa PC-3 xenograft. After the in-vitro assessment of receptor binding, PC-3 tumor-bearing mice were injected with [44Sc]Sc/[68Ga]Ga-NODAGA-AMBA (in blocking studies with bombesin) and in-vivo PET examinations were performed to determine the radiotracer uptake in standardized uptake values (SUV). 44Sc/68Ga-labelled NODAGA-AMBA was produced with high molar activity (approx. 20 GBq/µmoL) and excellent radiochemical purity. The in-vitro accumulation of [44Sc]Sc-NODAGA-AMBA in PC-3 cells was approximately 25-fold higher than that of the control HaCaT cells. Relatively higher uptake was found in vitro, ex vivo, and in vivo in the same tumor with the 44Sc-labelled probe compared to [68Ga]Ga-NODAGA-AMBA. The GRPR specificity of [44Sc]Sc-NODAGA-AMBA was confirmed by significantly (p ≤ 0.01) decreased %ID and SUV values in PC-3 tumors after bombesin pretreatment. The outstanding binding properties of the novel [44Sc]Sc-NODAGA-AMBA to GRPR outlines its potential to be a valuable radiotracer in the imaging of GRPR-positive PCa