Cyclopropanation of carbon-carbon double bonds in ring d of ergot alkaloids

Some ergot alkaloid derivatives containing a double bond in ring D have been reacted with diazomethane/palladium diacetate reagent to result in formation of a fused cyclopropane ring. This procedure proved to be generally applicable for cyclopropanation of Ergot alkaloids

What NMR can do in the biopharmaceutical industry

LBK

ANALYSE DES SÉRIES DES DONNÉS DES DÉBITS DES COURS D'EAU DANS LE DOMAIN DES ÉTIAGES

The discharges of the water courses are generated by the procedure of the precipitation - which is an easily analysable stochastic procedure. The procedure of the discharges is transformed by the boundary conditions of the water system. Consequently the procedure is a very complicated structured stochastic procedure. The Cramer-Leadbetter crossing method was constructed for analysis of such complicated stochastic procedures. For the water management purposes it is needed to complete the random variables introduced by Cramer and Leadbetter with the sum and extrem values of these parameters. Finally the stochastic procedure will be characterised by the series of condition al probability distribution of 17 random variables defined by the different crossing levels. To complete the information the Poissonian structure of the highwaters and the exponential character of the recession curves were used. A special tank model was used to deduce analytical formulas for the distribution functions of these 17 random variables. Two more sophisticated models were constructed - these models the condition al prob- ability functions can be estimated by numerical algorithms with help of the adequate software