14 research outputs found
Oxidative stress, advanced glycation end products and residual renal function in the rat model of unilateral ureteral obstruction: effects of phlogenzym and losartan
Aim. Oxidative stress plays a role in the pathogenesis of ureteral obstruction. Methods. We studied parameters of oxidative status, levels of advanced glycation end products (AGEs), and contralateral (CL) kidney function in the rat model of unilateral ureteral obstruction (UUO). The effect of Phlogenzym (12 mg/day orally); losartan (20 mg/l in drinking water), and their combination was studied. Results. In placebo-administered UUO rats AGEs and malondialdehyde levels were higher than in the sham operated controls. Function of the CL kidney was slightly impaired, its collagen content and protein/deoxyribonucleic acid ratio (P/DNA) in the glomeruli increased. All treatments prevented the rise in collagen content, P/DNA ratio, and improved CL kidney function. Phlogenzym ameliorated lipid peroxidation and AGE levels. Conclusions. In the model of UUO systemically increased oxidative stress may play a role in development of tubulointerstitial fibrosis and in the functional impairment of the CL kidney. Suppression of the oxidative stress and blockade of angiotensin-1 receptors might mitigate the progression of obstructive uropathy.ΠΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΈΠΉ ΡΡΡΠ΅Ρ Π²ΡΠ΄ΡΠ³ΡΠ°Ρ Π·Π½Π°ΡΠ½Ρ ΡΠΎΠ»Ρ Ρ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Ρ ΠΎΠ±ΡΡΡΡΠΊΡΡΡ ΡΠ΅ΡΠΎΠ²ΠΎΠ΄Ρ. ΠΠ΅ΡΠ° ΡΠΎΠ±ΠΎΡΠΈ ΠΏΠΎΠ»ΡΠ³Π°Π»Π° Ρ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΡΠ² ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΡ, ΠΎΡΡΠ½ΡΠ²Π°Π½Π½Ρ ΡΡΠ²Π½Ρ ΠΊΡΠ½ΡΠ΅Π²ΠΈΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΡΠ² Π³Π»ΡΠΊΠ°ΡΡΡ Ρ ΡΡΠ½ΠΊΡΡΠΎΠ½ΡΠ²Π°Π½Π½Ρ ΠΊΠΎΠ½ΡΡΠ°Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΡ Π½ΠΈΡΠΊΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΡΡΡΡΠ² Π· ΡΠ½ΡΠ»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΡ ΠΎΠ±ΡΡΡΡΠΊΡΡΡΡ ΡΠ΅ΡΠΎΠ²ΠΎΠ΄Ρ (Π£ΠΠ‘). ΠΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ° ΠΌΠΎΠ΄Π΅Π»Ρ Π£ΠΠ‘ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π»ΠΈ Π΅ΡΠ΅ΠΊΡΠΈ ΡΠ»ΠΎΠ³Π΅Π½Π·ΠΈΠΌΡ (12 ΠΌΠ³ Π² Π΄Π΅Π½Ρ ΠΎΡΠ°Π»ΡΠ½ΠΎ) Ρ Π»ΠΎΡΠ°ΡΡΠ°Π½Ρ (20 ΠΌΠ³/Π» Ρ ΠΏΠΈΡΠ½ΡΠΉ Π²ΠΎΠ΄Ρ), Π° ΡΠ°ΠΊΠΎΠΆ ΡΡ
Π½ΡΠΎΡ ΠΊΠΎΠΌΠ±ΡΠ½Π°ΡΡΡ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ. Π£ ΡΡΡΡΠ² Π· Π£ΠΠ‘, ΡΠΊΡ ΠΎΡΡΠΈΠΌΡΠ²Π°Π»ΠΈ ΠΏΠ»Π°ΡΠ΅Π±ΠΎ, ΡΡΠ²Π΅Π½Ρ Π½Π°ΠΊΠΎΠΏΠΈΡΠ΅Π½Π½Ρ ΠΊΡΠ½ΡΠ΅Π²ΠΈΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΡΠ² Π³Π»ΡΠΊΠ°ΡΡΡ ΡΠ° ΠΌΠ°Π»ΠΎΠ½Π΄ΡΠ°Π»ΡΠ΄Π΅Π³ΡΠ΄Ρ Π²ΠΈΡΠ²ΠΈΠ²ΡΡ Π²ΠΈΡΠΈΠΌ, Π½ΡΠΆ Ρ Π½Π΅ΡΠΏΡΠ°Π²ΠΆΠ½ΡΠΎΠΎΠΏΠ΅ΡΠΎΠ²Π°Π½ΠΈΡ
ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΠΈΡ
ΡΡΡΡΠ². Π€ΡΠ½ΠΊΡΡΠΎΠ½ΡΠ²Π°Π½Π½Ρ ΠΊΠΎΠ½ΡΡΠ°Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΡ Π½ΠΈΡΠΊΠΈ Π½Π΅Π·Π½Π°ΡΠ½ΠΎ ΠΏΠΎΠ³ΡΡΡΠΈΠ»ΠΎΡΡ, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ ΠΊΠΎΠ»Π°Π³Π΅Π½Ρ Ρ ΡΠΏΡΠ²Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ Π²ΠΌΡΡΡΡ Π±ΡΠ»ΠΎΠΊ/Π΄Π΅Π·ΠΎΠΊΡΠΈΡΠΈΠ±ΠΎΠ½ΡΠΊΠ»Π΅ΡΠ½ΠΎΠ²Π° ΠΊΠΈΡΠ»ΠΎΡΠ° (P/ DNA) Ρ ΠΊΠ»ΡΠ±ΠΎΡΠΊΡ Π½ΠΈΡΠΊΠΈ ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Ρ. ΠΠ±ΡΠΎΠ±ΠΊΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π½ΠΈΠΌΠΈ Π»ΡΠΊΠ°ΡΡΡΠΊΠΈΠΌΠΈ Π·Π°ΡΠΎΠ±Π°ΠΌΠΈ Π·Π°ΠΏΠΎΠ±ΡΠ³Π°Π»Π° Π·Π±ΡΠ»ΡΡΠ΅Π½Π½Ρ Π²ΠΌΡΡΡΡ ΠΊΠΎΠ»Π°Π³Π΅Π½Ρ, Π·ΡΠΎΡΡΠ°Π½Π½Ρ ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠ° ΡΠΏΡΠ²Π²ΡΠ΄Π½ΠΎΡΠ΅Π½Π½Ρ P/DNA ΡΠ° ΠΏΠΎΠΊΡΠ°ΡΡΠ²Π°Π»Π° ΡΡΠ½ΠΊΡΡΠΎΠ½ΡΠ²Π°Π½Π½Ρ ΠΊΠΎΠ»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΡ Π½ΠΈΡΠΊΠΈ. Π€Π»ΠΎΠ³Π΅Π½Π·ΠΈΠΌ ΡΠΏΡΠΈΡΠ² ΠΏΡΠ΄Π²ΠΈΡΠ΅Π½Π½Ρ ΡΡΠ²Π½Ρ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π»ΡΠΏΡΠ΄ΡΠ² ΡΠ° ΠΊΡΠ½ΡΠ΅Π²ΠΈΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΡΠ² Π³Π»ΡΠΊΠ°ΡΡΡ. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. Π£ ΠΌΠΎΠ΄Π΅Π»Ρ Π£ΠΠ‘ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ½Π΅ Π·Π±ΡΠ»ΡΡΠ΅Π½Π½Ρ ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡ ΠΌΠΎΠΆΠ΅ Π²ΡΠ΄ΡΠ³ΡΠ°Π²Π°ΡΠΈ Π²Π°ΠΆΠ»ΠΈΠ²Ρ ΡΠΎΠ»Ρ Ρ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΡΡΠ±ΡΠ»ΠΎΡΠ½ΡΠ΅ΡΡΡΠΈΡΡΠΉΠ½ΠΎΠ³ΠΎ ΡΡΠ±ΡΠΎΠ·Ρ Ρ ΠΏΠΎΡΡΡΠ΅Π½Π½Ρ ΡΡΠ½ΠΊΡΡΠΎΠ½ΡΠ²Π°Π½Π½Ρ ΠΊΠΎΠ½ΡΡΠ°Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΡ Π½ΠΈΡΠΊΠΈ. Π‘ΡΠΏΡΠ΅ΡΡΡ ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡ ΡΠ° Π±Π»ΠΎΠΊΡΠ²Π°Π½Π½Ρ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° Π°Π½Π³ΡΠΎΡΠ΅Π½Π·ΠΈΠ½Ρ-1 ΠΌΠΎΠΆΡΡΡ ΠΏΠΎΡΠ»Π°Π±Π»ΡΠ²Π°ΡΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΡ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΡ ΡΡΠΎΠΏΠ°ΡΡΡ.ΠΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΡΠΉ ΡΡΡΠ΅ΡΡ ΠΈΠ³ΡΠ°Π΅Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΡ ΡΠΎΠ»Ρ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠΈ ΠΌΠΎΡΠ΅ΡΠΎΡΠ½ΠΈΠΊΠ°. Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ ΡΠΎΡΡΠΎΡΠ»Π° Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΠ°ΡΡΡΠ°, ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΡΠΎΠ²Π½Ρ ΠΊΠΎΠ½Π΅ΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π³Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠ°Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΊΡΡΡ Ρ ΡΠ½ΠΈΠ»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ΅ΠΉ ΠΌΠΎΡΠ΅ΡΠΎΡΠ½ΠΈΠΊΠ° (Π£ΠΠ). ΠΠ΅ΡΠΎΠ΄ΠΈ. ΠΠ° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π£ΠΠ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΡΡΡΠ΅ΠΊΡΡ ΡΠ»ΠΎΠ³Π΅Π½Π·ΠΈΠΌΠ° (12 ΠΌΠ³ Π² Π΄Π΅Π½Ρ ΠΎΡΠ°Π»ΡΠ½ΠΎ) ΠΈ Π»ΠΎΡΠ°ΡΡΠ°Π½Π° (20 ΠΌΠ³/Π» Π² ΠΏΠΈΡΡΠ΅Π²ΠΎΠΉ Π²ΠΎΠ΄Π΅), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ ΠΊΡΡΡ Ρ Π£ΠΠ, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
ΠΏΠ»Π°ΡΠ΅Π±ΠΎ, ΡΡΠΎΠ²Π΅Π½Ρ ΠΊΠΎΠ½Π΅ΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π³Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΠΈ ΠΌΠ°Π»ΠΎΠ½Π΄ΠΈΠ°Π»ΡΠ΄Π΅Π³ΠΈΠ΄Π° ΠΎΠΊΠ°Π·Π°Π»ΡΡ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ Π»ΠΎΠΆΠ½ΠΎΠΎΠΎΠΏΠ΅ΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΠΎΠ½ΡΡΠΎΠ»ΡΠ½ΡΡ
ΠΊΡΡΡ. Π€ΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΡΠ°Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ Π½Π΅Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡ
ΡΠ΄ΡΠΈΠ»ΠΎΡΡ, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° ΠΈ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ Π±Π΅Π»ΠΎΠΊ/Π΄Π΅Π·ΠΎΠΊΡΠΈΡΠΈΠ±ΠΎΠ½ΡΠΊΠ»Π΅ΠΈΠ½ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° (P/DNA) Π² ΠΊΠ»ΡΠ±ΠΎΡΠΊΠ΅ ΠΏΠΎΡΠΊΠΈ ΠΏΠΎΠ²ΡΡΠΈΠ»ΠΈΡΡ. ΠΠ±ΡΠ°Π±ΠΎΡΠΊΠ° ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠΌΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠΌΠΈ ΡΡΠ΅Π΄ΡΡΠ°Π²Π°ΠΌΠΈ ΠΏΡΠ΅Π΄ΠΎΡΠ²ΡΠ°ΡΠ°Π»Π° ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠΎΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π°, ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠΎΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ P/DNA ΠΈ ΡΠ»ΡΡΡΠ°Π»Π° ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠΎΠ»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ. Π€Π»ΠΎΠ³Π΅Π½Π·ΠΈΠΌ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π» Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ² ΠΈ ΠΊΠΎΠ½Π΅ΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π³Π»ΠΈΠΊΠ°ΡΠΈΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. Π ΠΌΠΎΠ΄Π΅Π»ΠΈ Π£ΠΠ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡΠ° ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΏΡΠΈΡΠΈΠ½ΠΎΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠ±ΡΠ»ΠΎΠΈΠ½ΡΠ΅ΡΡΡΠΈΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΈΠ±ΡΠΎΠ·Π° ΠΈ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠ½ΡΡΠ°Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΡΠΊΠΈ. Π‘ΡΠΏΡΠ΅ΡΡΠΈΡ ΠΎΠΊΡΠΈΠ΄Π°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡΠ° ΠΈ Π±Π»ΠΎΠΊΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° Π°Π½Π³ΠΈΠΎΡΠ΅Π½Π·ΠΈΠ½Π°-1 ΠΌΠΎΠΆΠ³ΡΡ ΠΎΡΠ»Π°Π±Π»ΡΡΡ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΡΠΎΠΏΠ°ΡΠΈΠΈ
The versatility of carboxytherapy in pathogenic therapy
Carbon dioxide is a powerful physiological regulator (physiological and pharmacological pacemaker)
of numerous body systems: cardiovascular, respiratory, nervous, excretory, hematopoietic, immune,etc. Therefore, at present, carboxytherapy, due to the universal nature of pharmacodynamics, its physiology is one of the methods widely used in medicine for the treatment of a large number of diseases and has received official recognition in many countries worldwide. The use of CO2 in surgery is
not limited to disinfection of surgical wounds, wound healing, anti-inflammatory, hemostatic and
antioxidant effects. Inhaling carbon dioxide in a low concentration (3-5%) has a reflex stimulating effect
on the respiratory and vasomotor centers of the medulla oblongata: it causes deep and rapid breathing, and excitation of the vasomotor center - an increase in heart rate and blood pressure. This reflex effect of CO2 is used during anesthesia to stimulate pulmonary ventilation with a mixture of CO2 and O2 (carbogen) while suppressing pulmonary ventilation. Inhalation of CO2 helps with vascular
collapse to increase cerebral blood flow. Thus, carboxytherapy in the complex of pharmacotherapeutic
treatment of diseases is a worthy alternative to drugs that have synergistic pathogenetic (antioxidant,
antihypoxic, anti-inflammatory) and symptomatic (vasodilator, analgesic, hypolipidemic, antiseptic,
reparative) effects.
Keywords: carbon dioxide, carboxytherapy, pathogenic therapy
Impact of preoperative mild cognitive impairment on cerebrovascular events and cognitive status in patients undergoing coronary artery bypass grafting: data from 5-year follow-up
Aim. To assess the incidence of cerebrovascular events and cognitive status in the long-term period after coronary artery bypass grafting (CABG) in patients with and without preoperative mild cognitive impairment (MCI).Material and methods. This prospective study involved 115 patients aged 45 to 69 years, who were admitted to the hospital for elective on-pump CABG. All patients underwent clinical, laboratory, ultrasound, neuroimaging and neuropsychological examination 3-5 days before and 5-7 years after CABG. Cognitive functioning was assessed using screening neuropsychological scales and neuropsychological testing with an assessment of neurodynamics, attention and short-term memory. Pre-CABG MCI was diagnosed based on the criteria by R. Petersen et al. Therefore, the patients were divided into two groups: with (n=51) and without MCI (n=64).Results. It was found that strokes and dementia during the long-term postoperative period of CABG were observed only in the group of patients with preoperative MCI (7,84%). Five-seven years after CABG, a decrease in cognitive status according to neuropsychological scales was found in all patients (pβ€0,05). A decrease in neurodynamics, attention and short-term memory compared to the preoperative level was found in 47,92% of patients with preoperative MCI, without MCI β in 40,63%. Neurodynamic disorders occurred equally frequently in both groups (63,8% and 57,8% of patients, respectively). Memory impairments were more often observed in patients with MCI (55,3%) compared to those without MCI (34,4%) (OR=2,36, 95% CI, 1,09-5,12, p=0,03). According to brain multislice computed tomography in the group with preoperative MCI, the number of patients with cysts and leukoaraiosis 5-7 years after CABG was higher than in those without MCI (pβ€0,05).Conclusion. In the long-term (5-7 years) postoperative period of CABG, more than 40% of patients demonstrate a decrease in cognitive status, regardless of preoperative data. At the same time, preoperative MCI is associated with adverse cerebrovascular events and dementia, accompanied by morphological brain abnormalities. Due to the revealed facts, it is necessary to optimize approaches to drug treatment and secondary prevention of cognitive decline after cardiac surgery
ΠΠ΅ΠΉΡΠΎΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΡΠ°ΡΡΡ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΊΠ»Π°ΠΏΠ°Π½Π½ΠΎΠΉ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ
Aim. To evaluate the neuropsychological parameters from the main cognitive domains (neurodynamic functions, attention and short-term memory) and the brain electrical activity in patients with non-valve atrial fibrillation (AF).Methods. 21 patients with the mean age of 61 [56; 67] years with non-valve AF who were admitted to the Department of Interventional Diagnosis and Treatment at the Research Institute for Complex Issues of Cardiovascular Disease were included in the study. The control group consisted of 17 healthy individuals with the mean age of 55 [49; 62] years. All patients underwent neuropsychological screening and computerized testing of neurodynamic functions, attention and short-term memory along with electroencephalographic studies. Statistical analysis was performed using the STATISTICA 10.0 software package.Results. Mild cognitive impairment was observed in 43% of patients with non-valve AF accompanied by ischemic brain matter changes according to the findings of magnetic resonance imaging. Patients with AF had slower complex sensorimotor reaction, more errors, worse directed attention, memorization of words and meaningless syllables in comparison with healthy individuals. In addition, patients with AF and healthy subjects had differences in the fronto-occipital gradient of theta-2 rhythm. The worst neurodynamic parameters were associated with a greater power of theta rhythms predominantly in the posterior parts of the brain only in patients with AF.Conclusion. Patients with non-valve AF had cognitive deficit with impaired executive control, attention and short-term memory as well as the slowing of cortical electrical activity in comparison to healthy individuals. The data obtained in our study are beneficial for developing an individual approach to prevent the development and progression of cognitive impairment in patients with AF.Π¦Π΅Π»Ρ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π»ΠΎ ΡΠ΅Π»ΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΠΎΡΡΠ°ΠΆΠ°ΡΡΠΈΡ
Π΄Π΅ΡΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² (Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ½ΠΊΡΠΈΠΉ, Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΈ ΠΊΡΠ°ΡΠΊΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ) ΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΊΠΎΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΊΠ»Π°ΠΏΠ°Π½Π½ΠΎΠΉ ΡΠΈΠ±ΡΠΈΠ»Π»ΡΡΠΈΠ΅ΠΉ ΠΏΡΠ΅Π΄ΡΠ΅ΡΠ΄ΠΈΠΉ (Π€Π).ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±ΡΠ» Π²ΠΊΠ»ΡΡΠ΅Π½ 21 ΠΏΠ°ΡΠΈΠ΅Π½Ρ Ρ Π½Π΅ΠΊΠ»Π°ΠΏΠ°Π½Π½ΠΎΠΉ Π€Π, Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Π² ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ΅Π½ΡΠ³Π΅Π½Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΠΠ ΠΠΠ‘Π‘Π, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ ΡΠΎΡΡΠ°Π²ΠΈΠ» β 61 [56; 67] Π³ΠΎΠ΄Π°. ΠΡΡΠΏΠΏΡ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΈ 17 ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΠΈΡ, ΡΡΠ΅Π΄Π½ΠΈΠΉ Π²ΠΎΠ·ΡΠ°ΡΡ 55 [49; 62] Π»Π΅Ρ. ΠΡΠ΅ΠΌ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π½Π΅ΠΉΡΠΎΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ ΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ΅ ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ½ΠΊΡΠΈΠΉ, Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΈ ΠΊΡΠ°ΡΠΊΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ, ΡΠ»Π΅ΠΊΡΡΠΎΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅. ΠΡΠ΅ Π²ΠΈΠ΄Ρ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π±ΡΠ»ΠΈ Π²ΡΠΏΠΎΠ»Π½Π΅Π½Ρ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΏΡΠΎΠ³ΡΠ°ΠΌΠΌΠ½ΠΎΠ³ΠΎ ΠΏΠ°ΠΊΠ΅ΡΠ° STATISTICA 10.0.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π‘ΠΈΠ½Π΄ΡΠΎΠΌ ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΡ
ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ², ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π²ΡΠΈΠΉΡΡ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ Π΄ΠΈΡΡΠΈΡΠΊΡΠ»ΡΡΠΎΡΠ½ΡΡ
ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π²Π΅ΡΠ΅ΡΡΠ²Π° Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π°, ΠΏΠΎ Π΄Π°Π½Π½ΡΠΌ ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎ-ΡΠ΅Π·ΠΎΠ½Π°Π½ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ, Π½Π°Π±Π»ΡΠ΄Π°Π»ΡΡ Ρ 83% ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΠΊΠ»Π°ΠΏΠ°Π½Π½ΠΎΠΉ Π€Π. ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ Ρ Π€Π ΠΈΠΌΠ΅ΡΡ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΡΡ ΡΠΊΠΎΡΠΎΡΡΡ ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΠ΅Π½ΡΠΎΠΌΠΎΡΠΎΡΠ½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ, Π±ΠΎΠ»ΡΡΠ΅Π΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΎΡΠΈΠ±ΠΎΠΊ, Ρ
ΡΠ΄ΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ, Π·Π°ΠΏΠΎΠΌΠΈΠ½Π°Π½ΠΈΡ ΡΠ»ΠΎΠ² ΠΈ Π±Π΅ΡΡΠΌΡΡΠ»Π΅Π½Π½ΡΡ
ΡΠ»ΠΎΠ³ΠΎΠ² ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ. ΠΡΠΎΠΌΠ΅ ΡΠΎΠ³ΠΎ, ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ Ρ Π€Π ΠΈ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ ΠΈΠΌΠ΅ΡΡΡΡ ΡΠ°Π·Π»ΠΈΡΠΈΡ Π² Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΡΡΠΎΠ½ΡΠΎ-ΠΎΠΊΡΠΈΠΏΠΈΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ Π³ΡΠ°Π΄ΠΈΠ΅Π½ΡΠ° ΡΠ΅ΡΠ°-2-ΡΠΈΡΠΌΠ° ΠΈ ΡΠΎΠ»ΡΠΊΠΎ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π€Π Ρ
ΡΠ΄ΡΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π½Π΅ΠΉΡΠΎΠ΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ΅ΡΡΠΎΠ² Π±ΡΠ»ΠΈ Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Ρ Ρ Π±ΠΎΠ»ΡΡΠ΅ΠΉ ΠΌΠΎΡΠ½ΠΎΡΡΡΡ ΡΠ΅ΡΠ°-ΡΠΈΡΠΌΠΎΠ² ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π² Π·Π°Π΄Π½ΠΈΡ
ΡΠ΅Π³ΠΈΠΎΠ½Π°Ρ
ΠΊΠΎΡΡ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ°ΡΠΈΠ΅Π½ΡΡ Ρ Π½Π΅ΠΊΠ»Π°ΠΏΠ°Π½Π½ΠΎΠΉ Π€Π Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Ρ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π·Π΄ΠΎΡΠΎΠ²ΡΠΌΠΈ Π»ΠΈΡΠ°ΠΌΠΈ ΠΈΠΌΠ΅ΡΡ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΉ Π΄Π΅ΡΠΈΡΠΈΡ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌ ΠΈΡΠΏΠΎΠ»Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ, Π²Π½ΠΈΠΌΠ°Π½ΠΈΡ ΠΈ ΠΊΡΠ°ΡΠΊΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ ΠΏΠ°ΠΌΡΡΠΈ, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ Ρ Β«Π·Π°ΠΌΠ΅Π΄Π»Π΅Π½ΠΈΠ΅ΠΌΒ» ΠΊΠΎΡΠΊΠΎΠ²ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ Π² Π½Π°ΡΠ΅ΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π΄Π°Π½Π½ΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ ΠΏΠΎΠ»Π΅Π·Π½Ρ Π² ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠ΅Π»Π΅Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Π° ΠΊ ΠΏΡΠΎΡΠΈΠ»Π°ΠΊΡΠΈΠΊΠ΅ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π€Π
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎΠ΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²ΠΎ Π½Π° ΠΊΠ°ΡΠΎΡΠΈΠ΄Π½ΡΡ ΠΈ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΡ Π°ΡΡΠ΅ΡΠΈΡΡ
HighlightsThe presence of preoperative mild cognitive impairment (MCI) in patients undergoing combined carotid endarterectomy and coronary artery bypass grafting is associated with an increased theta activity at the frontal and parieto-occipital regions of both hemispheres after surgery.Β AbstractAim. To study the impact of preoperative cognitive impairment on changes in electrical activity of the brain in patients undergoing combined carotid endarterectomy and coronary artery bypass grafting.Methods. Sixty-three patients undergoing combined carotid endarterectomy (CAE) and coronary artery bypass grafting (CABG) were included in the study. The patients were divided into three groups, depending on the preoperative cognitive functions: without cognitive impairment (n = 17), with MCI (n = 29), and with severe cognitive impairment (n = 17). High-resolution electroencephalography (EEG) (62 channels, bandpass filtered between 0.1β50.0 Hz, sampling rate of 1000 Hz) was performed 3β5 days before and 7β10 days after surgery.Results. Patients with severe cognitive impairment at baseline presented with higher theta activity at the frontal region of the left hemisphere compared to patients without cognitive impairment and patients with MCI (p = 0.048). At the same time, patients with MCI showed the most pronounced theta activity increase after surgery compared to preoperative levels at the frontal and parieto-occipital cortical regions of both the left and right hemispheres (pβ€0.05). Postoperative changes of theta activity in patients with severe cognitive impairment were minimal and statistically insignificant.Conclusion. Patients without severe preoperative cognitive impairment presented with higher grade brain dysfunction in the form of increased theta activity at the frontal and parieto-occipital regions after combined CAE and CABG. A smaller decrease in theta power after surgery in patients with severe preoperative cognitive impairment, on the one hand, can indicate compensation after cerebral ischemia and resistance to hypoperfusion during on-pump cardiac surgery, and on the other, can be a manifestation of the ceiling effect and insufficiency of brain functional reserves.ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΏΠΎΠ»ΠΎΠΆΠ΅Π½ΠΈΡΠΠ°Π»ΠΈΡΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΌΠ΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ
ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎΠ΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²ΠΎ Π½Π° ΠΊΠ°ΡΠΎΡΠΈΠ΄Π½ΡΡ
ΠΈ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΡΡ
, Π°ΡΡΠΎΡΠΈΠΈΡΠΎΠ²Π°Π½ΠΎ Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ΅ΡΠ°-Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²ΠΎ ΡΡΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΏΠ°ΡΠΈΠ΅ΡΠΎ-ΠΎΠΊΡΠΈΠΏΠΈΡΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ΄Π΅Π»Π°Ρ
ΠΎΠ±ΠΎΠΈΡ
ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΠΉ.Β Π Π΅Π·ΡΠΌΠ΅Π¦Π΅Π»Ρ. ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° Π½Π° ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
, ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ
ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎΠ΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²ΠΎ Π½Π° ΠΊΠ°ΡΠΎΡΠΈΠ΄Π½ΡΡ
ΠΈ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΡΡ
.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. Π ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ ΡΡΠ°ΡΡΠ²ΠΎΠ²Π°Π»ΠΈ 63 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°, ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ
ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎ ΠΊΠ°ΡΠΎΡΠΈΠ΄Π½ΡΡ ΡΠ½Π΄Π°ΡΡΠ΅ΡΡΠΊΡΠΎΠΌΠΈΡ ΠΈ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΠΎΠ΅ ΡΡΠ½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΡ. Π Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΠΎΡΠ½ΠΈΡ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΡ
ΡΡΠ½ΠΊΡΠΈΠΉ ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° ΡΡΠΈ Π³ΡΡΠΏΠΏΡ: Π±Π΅Π· ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° (n = 17), Ρ ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΠΌ (n = 29) ΠΈ ΡΡΠΆΠ΅Π»ΡΠΌ (n = 17) ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΌ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ. ΠΠ»Π΅ΠΊΡΡΠΎΡΠ½ΡΠ΅ΡΠ°Π»ΠΎΠ³ΡΠ°ΡΠΈΡ Π²ΡΡΠΎΠΊΠΎΠ³ΠΎ ΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΡ (62 ΠΊΠ°Π½Π°Π»Π°, ΠΏΠΎΠ»ΠΎΡΠ° ΠΏΡΠΎΠΏΡΡΠΊΠ°Π½ΠΈΡ 0,1β50,0 ΠΡ, ΡΠ°ΡΡΠΎΡΠ° Π΄ΠΈΡΠΊΡΠ΅ΡΠΈΠ·Π°ΡΠΈΠΈ 1 000 ΠΡ) ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° Π·Π° 3β5 Π΄Π½Π΅ΠΉ ΠΈ Π½Π° 7β10-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π΄ΠΎ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΡΠΆΠ΅Π»ΡΠΌ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΌ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠ΅ΡΠ°-Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π²ΠΎ ΡΡΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ΄Π΅Π»Π°Ρ
Π»Π΅Π²ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΡ Π±ΡΠ»ΠΈ Π²ΡΡΠ΅, ΡΠ΅ΠΌ Ρ Π»ΠΈΡ Π±Π΅Π· ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²Π° ΠΈ Ρ ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΠΌ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΠ΅ΠΌ (p = 0,048). ΠΡΠΈ ΡΡΠΎΠΌ ΠΏΠΎΡΠ»Π΅ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠΌΠ΅ΡΠ΅Π½Π½ΡΠΌ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΌ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΎΡΡ ΠΌΠ°ΠΊΡΠΈΠΌΠ°Π»ΡΠ½ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΡΠ°-Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ ΡΡΠΎΠ²Π½Π΅ΠΌ Π²ΠΎ ΡΡΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΏΠ°ΡΠΈΠ΅ΡΠΎ-ΠΎΠΊΡΠΈΠΏΠΈΡΠ°Π»ΡΠ½ΡΡ
ΠΎΡΠ΄Π΅Π»Π°Ρ
ΠΊΠΎΡΡ Π»Π΅Π²ΠΎΠ³ΠΎ ΠΈ ΠΏΡΠ°Π²ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΡΡΠ°ΡΠΈΠΉ (pβ€0,05). Π’ΠΎΠ³Π΄Π° ΠΊΠ°ΠΊ Ρ Π»ΠΈΡ Ρ ΡΡΠΆΠ΅Π»ΡΠΌ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΌ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ ΠΏΠΎΡΠ»Π΅ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΡΠ΅ΡΠ°-ΡΠΈΡΠΌΠ° Π±ΡΠ»ΠΈ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½Ρ ΠΈ Π½Π΅ Π΄ΠΎΡΡΠΈΠ³Π°Π»ΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ°ΡΠΈΠ΅Π½ΡΡ Π±Π΅Π· ΡΡΠΆΠ΅Π»ΡΡ
ΡΠΎΡΠΌ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π΄Π΅ΡΠΈΡΠΈΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΎΠ΄Π½ΠΎΠΌΠΎΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π° Π½Π° ΠΊΠ°ΡΠΎΡΠΈΠ΄Π½ΡΡ
ΠΈ ΠΊΠΎΡΠΎΠ½Π°ΡΠ½ΡΡ
Π°ΡΡΠ΅ΡΠΈΡΡ
Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ Π±ΠΎΠ»ΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΌΠΎΠ·Π³ΠΎΠ²ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌ ΡΠ΅ΡΠ°-Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠΎΠ½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈ ΠΏΠ°ΡΠΈΠ΅ΡΠΎ-ΠΎΠΊΡΠΈΠΏΠΈΡΠ°Π»ΡΠ½ΡΡ
ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ ΠΊΠΎΡΡ ΠΌΠΎΠ·Π³Π°. ΠΡΠΈ ΡΡΠΎΠΌ ΠΌΠ΅Π½ΡΡΠ°Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΡ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΡΠ΅ΡΠ°-ΡΠΈΡΠΌΠ° ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ
Ρ ΡΡΠΆΠ΅Π»ΡΠΌ ΠΏΡΠ΅Π΄ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ ΠΊΠΎΠ³Π½ΠΈΡΠΈΠ²Π½ΡΠΌ ΡΠ°ΡΡΡΡΠΎΠΉΡΡΠ²ΠΎΠΌ, Ρ ΠΎΠ΄Π½ΠΎΠΉ ΡΡΠΎΡΠΎΠ½Ρ, ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΠΈΠ½Π΄ΠΈΠΊΠ°ΡΠΎΡΠΎΠΌ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΈΠΈ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΡΠ΅ΠΌΠΈΠΈ Π³ΠΎΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΠΌΠΎΠ·Π³Π° ΠΈ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΠΈ ΠΊ Π³ΠΈΠΏΠΎΠΏΠ΅ΡΡΡΠ·ΠΈΠΈ ΠΏΡΠΈ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΠΊΡΠΎΠ²ΠΎΠΎΠ±ΡΠ°ΡΠ΅Π½ΠΈΠΈ, Ρ Π΄ΡΡΠ³ΠΎΠΉ β ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΡΠΎΠ»ΠΎΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎΡΡΠΈ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠ΅Π·Π΅ΡΠ²ΠΎΠ²
STRUCTURE OF COGNITIVE DISORDERS AND DYNAMICS OF BIOELECTRIC ACTIVITY OF THE BRAIN IN PATIENTS AFTER DIRECT MYOCARDIAL REVASCULARIZATION
Aim. To analyze structural chareacteristics and electroencephalographic (EEG) pattern of post-operation cognitive dysfunction (POCD) in patients after direct myocardial revascularization under artificial circulation (AI). Material and methods. Totally 114 male-patients included, underwent scheduled coronary bypass grafting (CBG) under the AI, with average age 55,9Β±5,3 y. In 3-5 days before operation and on 7-10 day after all patients underwent neurophysiological testing; of those 65 patients also underwent EEG. Results. The CBG operation with AI leads in 79% of cases to the early POCD. Cognitive impairment usually becomes prominent in the domains of neurodynamics and memory. It is shown that the early POCD is followed by EEG-signs of cortical dysfunction (increase of low-frequency theta-rhythm magnitude).Conclusion. According to the results of the study, in post-operative CBG with AI period the structure of POCD consists of injury of neurodynamics and memory, which might be a cause of decreased life quality of patients and efficacy of surgery itself
TRAIT ANXIETY AS A RISK FACOR OF COGNITIVE DYSFUNCTION IN PATIENTS AFTER MYOCARDIAL REVASCULARIZATION
Aim. To study the effects of trait anxiety (TA) on the post-CABG (coronary artery bypass graft surgery) dynamics of cognitive function in patients with coronary heart disease (CHD). Material and methods. In total, 52 patients, aged 45β70 years, were divided into two groups: with moderate (n=24) and high (n=28) levels of TA. Results. The patients with high TA demonstrated worse cognitive function parameters 6 months after CABG, compared to the patients with moderate TA levels. Conclusion. High TA levels are one of the factors which negatively affect cognitive function parameters in CHD patients. These patients could be regarded at increased risk of post-CABG cerebrovascular complications
Sex characteristics of cognitive functions assessed by the MMSE and MoCA scores in patients with coronary artery disease
Aim. To study the sex characteristics of cognitive functions in a cohort of patients undergoing coronary artery bypass grafting (CABG) by comparing the results of Mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores.Material and methods. The prospective cohort study included 272 people, including 74 women aged 41 to 82 years, who were admitted to the Research Institute of Complex Issues of Cardiovascular Diseases for CABG surgery. All patients underwent clinical, laboratory, electrophysiological and ultrasound examinations. The Charlson comorbidity index (CCI) was calculated. Assessment of cognitive functions was carried out using the MMSE and MoCA scores. All types of statistical analysis were performed using the STATISTICA 10 program (StatSoft Inc., USA).Results. It was found that women scheduled for CABG have an older age and a higher CCI score compared to men (p=0,008). According to the MMSE, the likelihood of moderate and severe cognitive impairment in men compared with women was 1,36 times higher (odds ratio (OR), 1,35; 95% confidence interval (CI), 0,79-2,32, Z=1,11, p=0,27). The MoCA scores showed that half of the male (49%) and female (50%) participants had severe cognitive impairment. The likelihood of moderateand severe cognitive impairment in men compared with women was 1,33 times higher (OR, 1,33; 95% CI, 0,68-2,59, Z=0,841, p=0,40). According to subtests of the MoCA, men were better in naming (p=0,002), abstraction (p=0,005), and women outperformed men in verbal fluency (p=0,04). Regression analysis revealed that the most significant negative predictors for cognitive status as measured by the MMSE and MoCA scores for men and women were age and CCI.Conclusion. Women scheduled for CABG, having the worst clinical and demographic indicators, are comparable with men in cognitive status using the MMSE score. The MoCA score shows sex differences in naming, abstraction, and verbal fluency domains and revealed a higher percentage of severe cognitive disorders (up to 50%) compared to the MMSE score (7-9%). In male and female candidates for CABG, age and comorbidities are negatively associated with cognitive status