Making Fathers Count: Assessing the Progress of Responsible Fatherhood Efforts

This report provides a history of the issue of fatherhood in policy debates and philanthropic action from the late 1960's through the present day. It then outlines research findings in seven core areas of fatherhood and discusses accomplishments and challenges for policymakers

Restoring Fathers to Families and Communities: Six Steps for Policymakers

Presents a detailed strategy for legislative and administrative efforts that state and local officials can implement to promote father involvement, especially among low-income, unwed men

Re-thinking roadway preservation

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2009."June 2009."Includes bibliographical references (p. 95-98).Most of the roads built over the last century in the US were built assuming that efficient mobility for drivers was most important without considering impacts to the natural or built environment. Urban neighborhoods were severed, ecologically sensitive areas were disrupted, and pedestrian, bicycle and transit accommodation was ignored. Public offense at this approach to road-building led to new policies and practices for more open, locally-based decision-making. Road construction is now subject to a higher level of scrutiny, yet investment is preserving existing roads is assumed with little public discussion even though preservation represents the majority of transportation expenditures. As public priorities shift toward favoring sustainable development and transforming out of auto-dependency, road preservation can be either a barrier or an opportunity. This study examines whether and how road preservation investments support these new priorities. I use the Maryland State Highway Administration (MSHA) as a case study. As a national leader in context-sensitive solutions and in commitment to sustainable development, MSHA is expected to exhibit innovative use of system preservation expenditures to support local plans for more balanced, less auto-intensive transportation systems. I find that rather than integrate context -sensitivity and sustainability into all transportation programs, Asset Management-based preservation programs focus almost exclusively on cost-efficiency while alternate programs are created to address broader concerns.(cont.) Policies for context-sensitive solutions, flexible transportation investment, and sustainable development have little bearing on Asset Management -based preservation investments. MSHA's Neighborhood Conservation program offers a good model for locally-based, flexible preservation investment, though the fund has been susceptible to budget cuts. Asset Management systems are an important tool for managing risk and cost associated with an aging transportation system. However, as reliance on Asset Management-based investment grows, the narrow scope of these projects will undermine commitment to responsive, sustainable transportation investment. The decision-making process for these investments should be supplemented through small-area preservation planning, incentive funds for preservation project enhancements, and performance measures that focus investment on broad transportation goals in order to achieve reduced auto-dependency and transportation investment that supports public priorities.by Kathleen R. Sylvester.M.C.P

An Intervention Approach for Children with Teacher- and Parent-Identified Attentional Difficulties

Using a multimodal and multi-informant method for diagnosis, we selected 33 children by teacher and parent nomination for attention and work completion problems that met DSM-IV criteria for attention-deficit/hyperactivity disorder (ADHD). Of the 33 children in this group, 21 participated in the initial intervention, and 12 were placed in an ADHD control group and received the intervention after pre- and post-testing. A similarly selected group of 21 children without difficulties in attention and work completion served as a control group. Each child was assessed on pre- and posttest measures of visual and auditory attention. After an 18-week intervention period that included attention and problem-solving training, all children in the intervention and control groups were retested on visual and auditory tasks. Children in both ADHD groups showed significantly poorer initial performance on the visual attention task. Whereas the ADHD intervention group showed commensurate performance to the nondisabled control group after training, the ADHD control group did not show significant improvement over the same period. Auditory attention was poorer compared to the control group for both ADHD groups initially and improved only for the ADHD intervention group. These findings are discussed as a possible intervention for children with difficulties in strategy selection in a classroom setting

Changes in Adolescent Birth Rates within Appalachian Subregions and Non-Appalachian Counties in the United States, 2012–2018

Background: Adolescent births are associated with numerous challenges. While adolescent birth rates have declined across the U.S., disparities persist and little is known about the extent to which broader declines are seen within Appalachia. Purpose: The purpose of this study was to examine the extent to which adolescent birth rates have declined across the subregions of Appalachia relative to non-Appalachia. Methods: We conducted a retrospective study of adolescent birth rates between 2012 and 2018 using county-level vital records data. Differences were examined across the subregions of Appalachia and among non-Appalachian counties. Multiple regression models were used to examine changes in the rate of decline over time, adjusting for additional covariates of relevance. Results: About 13.4% of all counties in the U.S. are within the Appalachian region. The rate of adolescent births decreased by 12.6 adolescent births per 1,000 females between 2012 and 2018 across the U.S. While all regions experienced declines in the rate of adolescent births, Central Appalachia had the largest reduction in adolescent births (18.5 per 1,000 females), which was also noted in the adjusted models when compared to the counties of non-Appalachia (b= –5.78, CI: –9.58, –1.97). Rates of adolescent birth were markedly higher in counties considered among the most socially and economically vulnerable. Implications: This study demonstrates that the rates of adolescent births vary across the subregions of Appalachia but have declined proportional to rates in non-Appalachia. While adolescent birth rates remain higher in select subregions of Appalachia compared to non-Appalachia, the gap has narrowed considerably

beta-estradiol attenuates the anti-HIV-1 efficacy of Stavudine (D4T) in primary PBL

<p>Abstract</p> <p>Background</p> <p>Female hormones are known to play an important role in predisposition for many infectious diseases. Recent work suggests there are gender effects in HIV/AIDS progression. Here we ask whether the sex steroid hormone β-estradiol affects the replication of HIV-1 or the efficacy of a common anti-retroviral drug, Stavudine (D4T).</p> <p>Results</p> <p>Human PBL were infected with HIV-1 in the presence or absence of combinations of sex steroid hormones and the anti-retroviral drug, D4T. After seven days in culture, viral supernatants were assayed for HIV-1 p24 protein. β-estradiol resulted in a modest inhibition of HIV-1 replication of ~26%. However, 2 nM β-estradiol increased the amount of HIV-1 replication in the presence of 50 nM D4T from a baseline of 33% (+/- SE = 5.4) to 74% (+/- SE = 5.4) of control virus levels in the absence of drug. Both results were statistically highly significant (p < 0.001). β-estradiol did not increase the replication of a D4T-resistant strain of HIV in the presence of D4T. The effects were unlikely to be due to general cell inhibition or toxicity because these concentrations of drug and hormone cause no cytotoxicity in PBL as measured by trypan blue exclusion.</p> <p>Conclusion</p> <p>β-estradiol inhibited both HIV-1 replication in primary human PBL and the antiretroviral efficacy of D4T in PBL cultures. To optimize antiretroviral drug therapy, it may be necessary to monitor patient hormonal status.</p

Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer

Epithelial ovarian cancer (OC) is the most deadly cancer of the female reproductive system. To date, there is no effective screening method for early detection of OC and current diagnostic armamentarium may include sonographic grading of the tumor and analyzing serum levels of tumor markers, Cancer Antigen 125 (CA-125) and Human epididymis protein 4 (HE4). Microorganisms (bacterial, archaeal, and fungal cells) residing in mucosal tissues including the gastrointestinal and urogenital tracts can be altered by different disease states, and these shifts in microbial dynamics may help to diagnose disease states. We hypothesized that the peritoneal microbial environment was altered in patients with OC and that inclusion of selected peritoneal microbial features with current clinical features into prediction analyses will improve detection accuracy of patients with OC. Blood and peritoneal fluid were collected from consented patients that had sonography confirmed adnexal masses and were being seen at SIU School of Medicine Simmons Cancer Institute. Blood was processed and serum HE4 and CA-125 were measured. Peritoneal fluid was collected at the time of surgery and processed for Next Generation Sequencing (NGS) using 16S V4 exon bacterial primers and bioinformatics analyses. We found that patients with OC had a unique peritoneal microbial profile compared to patients with a benign mass. Using ensemble modeling and machine learning pathways, we identified 18 microbial features that were highly specific to OC pathology. Prediction analyses confirmed that inclusion of microbial features with serum tumor marker levels and control features (patient age and BMI) improved diagnostic accuracy compared to currently used models. We conclude that OC pathogenesis alters the peritoneal microbial environment and that these unique microbial features are important for accurate diagnosis of OC. Our study warrants further analyses of the importance of microbial features in regards to oncological diagnostics and possible prognostic and interventional medicine.Ope

The Grizzly, April 23, 1990

Earth Day: Success! • Ready for Graduation • Letters: New Curriculum Comments; Studio Cottage Vandal Victims; In Support of Sanger • Condom Commission Report • New Meal Plans Next Year • Tracksters Finish Season at MACs • Lady Bears Run Ahead • Netters Roll • Bears Bounce • Hackers No More • Why Earth Day? • Earth Day: Serious? • RAs for 90-91 • Support Your Local RA • Art at UC • Tunnel Steams BWC • Lisa\u27s Heart\u27s in Art • Soda Can\u27s Debut • Video Reviews • Promotions for Faculty • Desktop Aids New Editor • Exam Schedulehttps://digitalcommons.ursinus.edu/grizzlynews/1256/thumbnail.jp

Parallel hippocampal-parietal circuits for self- and goal-oriented processing

The hippocampus is critically important for a diverse range of cognitive processes, such as episodic memory, prospective memory, affective processing, and spatial navigation. Using individual-specific precision functional mapping of resting-state functional MRI data, we found the anterior hippocampus (head and body) to be preferentially functionally connected to the default mode network (DMN), as expected. The hippocampal tail, however, was strongly preferentially functionally connected to the parietal memory network (PMN), which supports goal-oriented cognition and stimulus recognition. This anterior-posterior dichotomy of resting-state functional connectivity was well-matched by differences in task deactivations and anatomical segmentations of the hippocampus. Task deactivations were localized to the hippocampal head and body (DMN), relatively sparing the tail (PMN). The functional dichotomization of the hippocampus into anterior DMN-connected and posterior PMN-connected parcels suggests parallel but distinct circuits between the hippocampus and medial parietal cortex for self- versus goal-oriented processing