Polo like kinase 2 tumour suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer

The polo-like kinase PLK2 has recently been identified as a potential theranostic marker in the management of chemotherapy sensitive cancers. The methylation status of the PLK2 CpG island varies with sensitivity to paclitaxel and platinum in ovarian cancer cell lines. Importantly, extrapolation of these in vitro data to the clinical setting confirms that the methylation status of the PLK2 CpG island predicts outcomes in patients treated with carboplatin and paclitaxel chemotherapy. A second cell cycle regulator, p57Kip2, is also subject to epigenetic silencing in carboplatin resistance in vitro and in vivo, emphasising that cell cycle regulators are important determinants of sensitivity to chemotherapeutic agents and providing insights into the phenomenon of collateral drug sensitivity in oncology. Understanding the mechanistic basis and identification of robust biomarkers to predict collateral sensitivity may inform optimal use of chemotherapy in patients receiving multiple lines of treatment

Performance comparison of distributed generation installation arrangement in transmission system for loss control

Placing Distributed Generation (DG) into a power network should be planned wisely. In this paper, the comparison of having different installation arrangement of real-power DGs in transmission system for loss control is presented. Immune-brainstorm-evolutionary programme (IBSEP) was chosen as the optimization technique. It is found that optimizing fixed-size DGs locations gives the highest loss reduction percentage. Apart from that, scattered small-sized DGs throughout a network minimizes transmission loss more than allocating one biger-sized DG at a location

Currently Available Tools and Teaching Strategies for the Interprofessional Education of Students in Health Professions : Literature review

Interprofessional education (IPE) is designed to provide students from different health sectors with opportunities to work together to enhance future collaboration. The implementation of IPE activities is a current trend in various countries. This review exclusively targets IPE issues involving undergraduate health profession students and highlights various approaches in different regions. A total of 28 articles published in peer-reviewed journals between January 2012 and July 2015 were assessed to determine recent trends in IPE implementation. Nine main strategies were identified: simulation-based education programmes; rotations in rural and community settings; interprofessional training wards; patient-centred case studies; theme-centred workshops; student seminars; student-delivered lectures; health promotion activities; and interactive lectures in a common setting. Many of these institutions had not restricted themselves to a single strategy and supplemented these activities with additional teaching or learning methods. Recommendations gathered from these diverse approaches may assist the development of sustainable strategies for implementing IPE in undergraduate medical curricula

Enhanced Secure Multi Keyword Top-K Retrieval in Cloud

This research is capable to do cryptography with multi keywords search. This research is target to provide search files from cloud network using multi keywords. This paper is target to provide a security at the maximum level by includes encryption and decryption. The administrator has control of authorization and allowing files to move more secured. Encryption and decryption of files and file names which is used symmetric and asymmetric algorithm respectively. The unique key is generated for every users to protect other user cannot access the files. While implementing this project the user can understand very simple environment. The user can reduce incapable systems in server side process to hold most of the processes. The client side system has used less work for the corresponding task to perform the necessary role like arranging and ranking the files from requested order. This project can apply in various applications for this user friendly