Spreading of Persian Gulf water in the northwestern Arabian sea during the month of January

The presence of different water masses in the North Arabian Sea continues to remain of interest to scientists and researchers. Focus on these water masses is due to the unique monsoonal reversal features of the Arabian Sea. The encroachment of Persian Gulf water into the Arabian Sea has been acknowledged and traced. This paper presents the results of an investigation on the spreading patterns of Persian Gulf water in the northwestern Arabian Sea. The study incorporated two different techniques: the core-layer method and the constant sigma-theta surface method on data collected during the North Arabian Sea Environment and Ecosystem Research (NASEER) programme. Horizontal curves of temperature and salinity plotted by both methods show that the Persian Gulf water reduces in concentration as it moves from west to east, whereas the major direction of flow is along the coast of Oman. The results of the study indicate that features of the Persian Gulf water in the northwestern Arabian Sea are so pronounced that either of the method can be used to study and identify the water mass fairly well

Parametric Study of a Turbofan Engine With an Auxiliary High-Pressure Bypass

A parametric study of a novel turbofan engine with an auxiliary high-pressure bypass (AHPB) is presented. The underlying motivation for the study was to introduce and explore a configuration of a turbofan engine which could facilitate clean secondary burning of fuel at a higher temperature than conventionally realized. The study was also motivated by the developments in engineering materials for high-temperature applications and the potential utility of these developments. The parametric study is presented in two phases. Phase I presents a schematic of the turbofan engine with AHPB and the mathematics of the performance parameters at various stations. The proposed engine is hypothesized to consist of three streams—core stream, low-pressure bypass (LPB) stream, and the AHPB or, simply, the high-pressure bypass (HPB) stream. Phase II delves into the performance simulation and the analysis of the results in an ideal set-up. The simulation and results are presented for performance analysis when (i) maximizing engine thrust while varying the LPB and AHPB ratios, and (ii) varying the AHPB ratio while maintaining the LPB ratio constant. The results demonstrate the variations in performance of the engine and a basis for examining its potential utility for practical applications

Digitized Engineering Notebook

Digitized Engineering Notebook is a web application that allows students to record their work as they go through the process of their robotics competition. This notebook will portray the same qualities as the current engineering notebook. This digital version of an engineering notebook gives students a platform where they can upload data such as images, texts, videos to a database. Digitized engineering notebook will allow multiple users to log into the system, and work on same project at the same time. This web application will be developed in an open source environment called XAMPP. It will include multiple users. This Notebook can be categorized into queries which can be converted into PDF. The web application will have login credentials for every user and will also allow name-wise search of any user so their progress can be tracked. The functionalities of this Notebook will include a front page with menu, options to create new projects, addition of new members to the project, table of contents, etc., This web application will also contain a calendar so students can mark events. It will have a discussion board where students can interact with each other. The main goal of this web application is to inspire students to learn STEM engineering process. This Digitized Notebook will encourage knowledge sharing. The contents of the Notebook will be easy to query and share. It will allow students to work as a team remotely. This web application will be kids friendly and will allow students from K-12 to use it

Multi-subunit SARS-CoV-2 vaccine design using evolutionarily conserved T- and B- cell epitopes

The SARS-CoV-2 pandemic has created a public health crisis worldwide. Although vaccines against the virus are efficiently being rolled out, they are proving to be ineffective against certain emerging SARS-CoV-2 variants. The high degree of sequence similarity between SARS-CoV-2 and other human coronaviruses (HCoV) presents the opportunity for designing vaccines that may offer protection against SARS-CoV-2 and its emerging variants, with cross-protection against other HCoVs. In this study, we performed bioinformatics analyses to identify T and B cell epitopes originating from spike, membrane, nucleocapsid, and envelope protein sequences found to be evolutionarily conserved among seven major HCoVs. Evolutionary conservation of these epitopes indicates that they may have critical roles in viral fitness and are, therefore, unlikely to mutate during viral replication thus making such epitopes attractive candidates for a vaccine. Our designed vaccine construct comprises of twelve T and six B cell epitopes that are conserved among HCoVs. The vaccine is predicted to be soluble in water, stable, have a relatively long half-life, and exhibit low allergenicity and toxicity. Our docking results showed that the vaccine forms stable complex with toll-like receptor 4, while the immune simulations predicted that the vaccine may elicit strong IgG, IgM, and cytotoxic T cell responses. Therefore, from multiple perspectives, our multi-subunit vaccine design shows the potential to elicit a strong immune-protective response against SARS-CoV-2 and its emerging variants while carrying minimal risk for causing adverse effects