Use of etiotropic and pathogenetic medicines for COVID-19 in patients with renal failure and/or on dialysis

Impaired kidney function may influence pharmacokinetics of most of the drugs, including the ones used in COVID-19. In this publication, the most important pharmacokinetic parameters and dose adjustment approaches are provided, based on The Renal Drug Handbook и Sanford Guide. In the majority of cases, mild kidney function reduction does not necessitate dose adjustment. Each case should be considered individually, measuring benefits against risks

Assessment of the genetic distances between some species of the family Bradybaenidae (Mollusca, Pulmonata)

On the basis of inter-simple sequence repeat (ISSR) loci and the nucleotide sequences of nuclear (18S and ITS-1) and mitochondrial genes (COI and 16S), a phylogenetic analysis of the three species of terrestrial mollusks of the family Bradybaenidae (Mollusca, Pulmonata), Bradybaena fruticum Mull., Bradybaena schrencki Midd., and Bradybaena transbaicalia Shileyko, was conducted to clarify their taxonomic statu

Development of risk-oriented technologies of the corporate financial controlling system

Financial controlling is one of the functions of financial relations of management system whose main task is to monitor the correct functioning of these relations at the level of a certain managed object with the purpose to decide on sufficiency and effectiveness of managerial decisions. The article considers some peculiarities of creation of a corporate system of financial controlling on the basis of systematization of the existing theoretical and methodical approaches. Also the article presents some directions of improvement of financial controlling tools as well as the results of development of risk-oriented technologies which are aimed at providing financial stability of modern corporations.peer-reviewe

Assessment Of the Knowledge of Theoretical Basis of Punching Technique of Army Hand-To-Hand Combat by Students at The Initial Stage of Training

The article presents the results of knowledge of the theoretical foundations of the attacking technique of army hand-to-hand combat at the initial stage of training. Methodology. The pedagogical experiment was carried out with the participation of 24 RTU MIREA students. Results. With the help of specially developed questionnaires, it was revealed that as a result of the implementation of the experimental methodology for teaching the technique of attacking actions of army hand-to-hand combat, taking into account the general and specific in its content, there was a significant increase in the level of knowledge among the students of the experimental group. Conclusions. The obtained results of the study confirm the expediency of using active forms (problem learning) as a means of teaching the technique of army hand-to-hand combat, taking into account the general and specific in its content among students of the RTU MIREA university

Possibility to use barycytinib in patients with COVID-19, including for treatment of «cytokine storm»

Until clinical trials of efficacy and safety are obtained, routine use of barycytinib in patients with COVID-19 cannot be recommended

Rationality of routine clinical use of olokizumab in COVID-19

Routine clinical use of olokizumab in COVID-19 is not recommended. The use of olokizumab is possible in clinical trials

Genetic Risk Factors for Adverse Drug Reactions

The use of medicines may in some cases be associated with the development of drug-induced diseases (DIDs) аnd other adverse drug reactions (ADRs), which leads to an increase in morbidity/mortality rates, and/or symptoms forcing a patient to seek medical attention or resulting in hospitalisation. ADRs may develop due to changes in a patient’s genotype, which entail an inadequate pharmacological response. The aim of the study was to analyse and summarise literature data on genetic risk factors that cause DIDs аnd other ADRs. It was shown that the polymorphism of genes encoding enzymes of drug metabolism (CYP, UGT, NAT, TPMT, EPHX, GST, etc.) or carriers (transporters) of drugs (P-gp, BCRP, MRP, OATP, OCT, etc.) can change the pharmacokinetics of drugs, affecting their activity. Polymorphism of RYR1, CACNA1S, MT-RNR1, VKORC1, and other genes encoding receptors targeted by drugs, and human leukocyte antigen (HLA) gene, may affect drug pharmacodynamics by modifying drug targets or changing the sensitivity of biological pathways to pharmacological effects of medicines. Changes in drug pharmacokinetics and pharmacodynamics may cause DIDs аnd other ADRs. The use of pharmacogenetic tests will allow a personalised approach to patients’ treatment and prevention or timely detection of potential ADRs during therapy. Before prescribing some medicines, clinicians should use recommendations on their dosing based on pharmacogenetic tests, which are posted on the official websites of Pharmacogenomics Research Network (PGRN), Pharmacogenomics Knowledgebase (PharmGKB), and Clinical Pharmacogenetics Implementation Consortium (CPIC). The results of ongoing clinical studies on the effect of gene polymorphism on drug safety will soon allow for higher personalisation of the choice of pharmacotherapy and prevention of many ADRs, including DIDs

On stress drops in the sources of moderate and weak earthquakes: features of distribution in time

An analysis has been performed of the change in stress drops over time during the period of foreshock activity of strong earthquakes for two seismically active regions with different geodynamic settings: the Northern Tien Shan and the Southern Kuril Islands. The catalogs of earthquake dynamic parameters, DP (source ones in English publications), in these regions, with a number of events, were used as initial data. The DP catalog for the Northern Tien Shan includes 183 records of source parameters of earthquakes with magnitudes of 2.6–6.0, and the catalog for the Southern Kurils – 264 records. The stress drop values throughout a general sampling were analyzed as well as that in foreshock periods of 500 days length before the strongest earthquakes. For each region 12 such meaningful events have been specified, the magnitudes were М > 5 for the Northern Tien Shan, and М ≥ 6.5 for the Southern Kurils. The median average values of stress drops during 500-day period have been determined. The temporal variations of stress drops have been compared with changes in the b-value parameter (angular coefficient of earthquake recurrence plot) in the same observation periods. The computation of b-value for the case of the Northern Tien Shan involved the catalog data of KNET seismological network (1994–2021, more than 10 000 events), and the catalog of International Seismological Center (ISC, 1964–2000) for the Southern Kurils. In both cases, b-values were determined in 500-day moving interval with one day step. The computation gave the result that the well-known effect of b-value growth before strong earthquakes manifested itself explicitly in the considered regions. It has been established that such increase in b-value is accompanied by a decrease in the averaged stress drop values. The obtained results showed that the monitoring of the stress drop values can be used to identify the non stationary stage of the seismic regime

Current and future use of remdesivir in patients with COVID-19

There are prerequisites for the use of remdesivir against SARS-CoV-2 in stationary conditions. Remdesivir is not registered in the Russian Federation. The preliminary results of randomized clinical trials on the efficacy of remission are contradictory

Is it possible to use riamilovir to prevent infection and treat COVID-19?

Routine clinical use of riamilovir in COVID-19 is not recommended. The use of riamilovir is possible in clinical trials