Ventricular tachycardia after administration of sildenafil citrate: a case report

<p>Abstract</p> <p>Background</p> <p>It has not previously been reported that sildenafil citrate causes malignant arrhythmias in humans.</p> <p>Case presentation</p> <p>A 41-year-old man developed sustained ventricular tachycardia following sildenafil citrate administration.</p> <p>Conclusion</p> <p>It cannot be dismissed that this patient experienced ventricular tachycardia as an adverse effect of sildenafil citrate administration.</p

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Intermediatry steps in Acetobacter xylinum cellulose synthesis: studies with whole cells and cell-free preparations of the wild type and a celluloseless mutant

Intermediatry steps in cellulose synthesis in Acetobacter xylinum were studied with resting cells and particulate-membranous preparations of the wild-type strain and of a celluloseless mutant. Exogenously supplied [1-14C]glucose was rapidly converted by resting cells of both types into glucose 6-phosphate, glucose 1-phosphate, and uridine glucose 5'-diphosphate (UDP)-glucose and incorporated into lipid-, water-, and alkali-soluble cellular fractions. The decrease in the level of labeled hexose-phosphates and UDP-glucose upon depletion of the exogenous substrate was accounted for by a continuous incorporation of [14C]glucose into cellulose in the wild type and into the above-mentioned cellular components in the mutant. [14C]glucose retained in the alkali- and water-soluble fractions of pulse-labeled wild-type cells was quantitatively chased into cellulose. Sonic extracts of both strains catalyzed the transfer of glucose from UDP-glucose into lipid-, water-, and alkali-soluble materials, as well as into an alkali-insoluble cellulosic beta-1,4-glucan. The results strongly support the sequence glucose leads to glucose 6-phosphate leads to glucose 1-phosphate leads to UDP-glucose leads to cellulose and indicate that lipid- and protein-linked cellodextrins may function as intermediates between UDP-glucose and cellulose in A. xylinum.</jats:p

Mckittrick-Wheelock Syndrome and Diabetes Insipidus Case Report

Abstract Secretory villous adenoma is characterized with watery diarrhea, which may lead to dehydration, with resulting volume depletion, electrolyte imbalance, circulatory failure and renal dysfunction. We hereby report a case of villous adenoma associated with severe electrolyte imbalance complicated by diabetes insipidus. Successful management is available by strict preoperative monitoring and surgical resection of the tumor. The pathophysiology of this syndrome and the therapeutic implications are reviewed. Keywords: Villous adenoma; Hyperkalemia; Depletion Syndrome A sixty-one year old woman was admitted with a one-month history of weakness, confusion and a 5 kg weight loss. On examination she had 30 breaths per minute and was dehydrated. The blood pressure was 110/70 mmHg. Neurological examination indicated mild confusional state. The abdomen was soft and non-tender. No masses were felt on palpation or rectal examination. The patient&apos;s blood count and biochemistry on presentation is shown in Depletion syndrome is defined by villous adenoma of the colon associated with profuse watery diarrhea leading to serum electrolyte depletion, most often marked hyponatremia and hypokalemia and metabolic acidosis and is also known as McKittrick-Wheelock syndrome Discussio