Polish publications on jujutsu (1906-2020): bibliometric analysis

RESUMEN: El objetivo fue realizar un análisis bibliométrico de las publicaciones polacas sobre jujutsu centrado en los aspectos de productividad, asuntos y colaboración. Así, se consultaron la Biblioteca Nacional de Polonia, la Base de Revistas Científicas Polacas, la Web of Science y Scopus. Los resultados fueron filtrados y exportados a Excel 2016 para el análisis estadístico. Los documentos polacos sobre jujutsu alcanzaron los 123, publicados entre 1906 y 2020. Ciencias de la Vida fue el campo más representado, mientras que la colaboración predominó durante la última década. Cynarski fue el autor más productivo, mientras que Wojdat obtuvo el índice de colaboración más alto. Ido Movement for Culture fue el principal divulgador de estas publicaciones. En conclusión, las publicaciones polacas sobre jujutsu mostraron, durante el siglo XX, un predominio de libros técnicos escritos por autores individuales desde un abordaje de las Ciencias de la Vida, mientras que los artículos científicos escritos en colaboración y representando también otros enfoques han dominado en el siglo XXI.ABSTRACT: The aim was to perform a bibliometric analysis of Polish jujutsu publications focused on productivity, topics, and collaboration. Thus, the National Library of Poland, Polish Scientific Journals Database, Web of Science and Scopus were consulted. Results were filtered and exported to Excel 2016 for statistical analysis. 123 Polish jujutsu documents were published from 1906 to 2020. Life Sciences had the highest representation, while collaboration predominated during the last decade. Cynarski was the most productive author, while Wojdat achieved the highest collaboration index. Ido Movement for Culture was the main source for disseminating these publications. In conclusion, technical books written by single authors from a Life Sciences approach prevailed in Polish jujutsu publications during the 20th century, while scientific articles written in collaboration and also representing other approaches have prevailed in the 21st century

Through-space spin-spin coupling constants involving fluorine:benchmarking DFT functionals

Through-space spin–spin coupling constants (SSCCs) involving fluorine are computed applying Density Functional Theory and compared with experimental data to benchmark the performance of various functionals. In addition to the most often analysed J(FF) constants, we consider examples of J(FN), J(FP), J(FC) and J(FSe) constants. Basis sets optimised for the study of SSCCs are applied and thus we find the choice of the functional to be more important than the choice of the basis set. Different performance of DFT functionals is observed for different SSCCs, with the hybrid DFT functionals generally superior for the through-space couplings. When all the SSCCs are considered, PBE0 appears to be the most robust functional.</p

Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders

Recent studies have demonstrated that patients with myeloproliferative disorders (MPDs) frequently have acquired activating mutations in the JAK2 tyrosine kinase. A multikinase screen determined that lestaurtinib (formerly known as CEP-701) inhibits wild type JAK2 kinase activity with a concentration that inhibits response by 50% (IC50) of 1 nM in vitro. We hypothesized that lestaurtinib would inhibit mutant JAK2 kinase activity and suppress the growth of cells from patients with MPDs. We found that lestaurtinib inhibits the growth of HEL92.1.7 cells, which are dependent on mutant JAK2 activity for growth in vitro and in xenograft models. Erythroid cells expanded from primary CD34+ cells from patients with MPDs were inhibited by lestaurtinib at concentrations of 100 nM or more in 15 of 18 subjects, with concomitant inhibition of phosphorylation of STAT5 and other downstream effectors of JAK2. By contrast, growth of erythroid cells derived from 3 healthy controls was not significantly inhibited. These results demonstrate that lestaurtinib, in clinically achievable concentrations, inhibits proliferation and JAK2/STAT5 signaling in cells from patients with MPDs, and therefore holds promise as a therapeutic agent for patients with these disorders