Utility of Sea Surface Height anomaly (SSHa)in determination of Potential Fishing Zones

Physical processes in the oceans can be monitored by altimeters well before a radiometer can in terms of temperature or chlorophyll concentration. Herein we show the importance of Sea Surface Height anomaly (SSHa, retrieved with altimeter) in demarcating potential fishing zones. We also show how SSHa can help predict tuna movements, horizontally as well as vertically in the water column. Moreover, we prove these prediction with positively correlating SSHa to tuna hooking rates. In the end, we list out present and potential future sources from where SSHa can be retrieved in order to provide improved fishery advisories

Stability and Effective Process Control for Secure Email Filtering

A fantastic tool for both commercial and personal communication is electronic mail. It has increasingly become a necessary component of our working life since it is straightforward, available, and simple to use. Spam emails have started to tarnish internet experiences and threaten the integrity of email. Due to the exponential growth of spam, both people and organisations are under a great deal of financial and other strain. In order to prevent the future of email itself from being in jeopardy, a solution to the spam problem must be discovered. There is an urgent need to solve the Email spam issue since spam volume has been rising over the last several decades. As part of this effort, many effects of spam emails on businesses and people were noted and thoroughly examined. In order to properly assess current technologies, solutions, and methods, a comprehensive literature review was conducted throughout the procedures. The goals of this work is to develop new methodologies for the implementation of new strategies for the efficient management of email spam and to construct a proof-of-concept software system for the Process controlled assessment of such strategies

Laxative Property of Safoof-E-Sana, a Unani Formulation

An investigation was carried out to study the laxative property of aqueous extract Safoof-ESana in the unani formulation. Aqueous extract of Safoof-E-Sana was evaluated for laxative property and was measured by weighing the fecal out at 8th and 16th hour of drug administration. Safoof-E-Sana at 50, and 100 mg/kg showed dose dependent laxative effect. The results are compared with standard Senna. Safoof-E-Sana was showed significant laxative activity

Preliminary phytochemical screening and antimicrobial activity of Samanea saman

Samanea saman is a tropically distributed medicinal plant. Antimicrobial activity of aqueous extract of this plant was investigated by Well-diffusion method against three organisms: Escherichia coli, Staphylococcus aureus and Candida albicans. The plant extract showed inhibitory activity against all the tested organisms. Five mg/ml inhibited the growth of E. coli but slightly higher concentration of 10 mg/mL was necessary to show inhibition against S. aureus and C. albicans. Phytochemical screening of the plant revealed the presence of tannins, flavonoides, saponins, steroids, cardiac glycosides and terpenoids. The study scientifically validates the use of plant in traditional medicine

Utjecaj superdezintegratora na oslobađanje efavirenca iz tableta

Efavirenz (EFV) tablets of different doses were prepared by a wet granulation process using different superdisintegrants such as crosscarmellose sodium (CCS), sodium starch glycollate (SSG) and crosspovidone (CP) to evaluate the role of different disintegrants on the in vitro release of EFV. Further, the mode of addition of disintegrants on EFV dissolution from tablets containing 600 mg of the drug was evaluated by incorporating the disintegrant extragranularly (EG), intragranularly (IG) or distributing them equally (IG and EG). In vitro dissolution of the prepared tablets was conducted using the recommended medium and a dissolution medium developed in-house, which had the propensity to discriminate between the formulations. The t50 and t80 values were indicative of the fact that drug release was faster from tablet formulations containing CP. CP was able to release the drug faster than the other two disintegrants in both dissolution media and the drug release was unaffected by the mode of CP addition.U radu je opisana priprava tableta s različitim dozama efavirenca (EFV) metodom vlažne granulacije. Za tabletiranje korišteni su različiti superdezintegratori, poput natrijeve kroskarameloze (CCS), natrijeva škrobnog glikolata (SSG) i krospovidona (CP), kako bi se procijenio utjecaj vrste i načina dodavanja dezintegratora na oslobađanje EFV in vitro. U tu svrhu pripravljene su tablete sa 600 mg EFV, a dezintegrator je dodavan ekstragranularno (EG), intragranularno (IG) ili je bio podjednako raspršen (IG i EG). In vitro oslobađanje praćeno je u preporučenom mediju i mediju izrađenom u našem laboratoriju kako bi se uočila razlika između formulacija. Vrijednosti t50 i t80 ukazuju na to da je oslobađanje lijeka brže iz formulacija koje sadrže CP u oba medija. Način dodavanja CP nema utjecaj na oslobađanje lijeka, osim za CCS, gdje se ekstragranularno dodavanje pokazalo povoljnijim

Islet-Like Cell Aggregates Generated from Human Adipose Tissue Derived Stem Cells Ameliorate Experimental Diabetes in Mice

BACKGROUND: Type 1 Diabetes Mellitus is caused by auto immune destruction of insulin producing beta cells in the pancreas. Currently available treatments include transplantation of isolated islets from donor pancreas to the patient. However, this method is limited by inadequate means of immuno-suppression to prevent islet rejection and importantly, limited supply of islets for transplantation. Autologous adult stem cells are now considered for cell replacement therapy in diabetes as it has the potential to generate neo-islets which are genetically part of the treated individual. Adopting methods of islet encapsulation in immuno-isolatory devices would eliminate the need for immuno-suppressants. METHODOLOGY/PRINCIPAL FINDINGS: In the present study we explore the potential of human adipose tissue derived adult stem cells (h-ASCs) to differentiate into functional islet like cell aggregates (ICAs). Our stage specific differentiation protocol permit the conversion of mesodermic h-ASCs to definitive endoderm (Hnf3β, TCF2 and Sox17) and to PDX1, Ngn3, NeuroD, Pax4 positive pancreatic endoderm which further matures in vitro to secrete insulin. These ICAs are shown to produce human C-peptide in a glucose dependent manner exhibiting in-vitro functionality. Transplantation of mature ICAs, packed in immuno-isolatory biocompatible capsules to STZ induced diabetic mice restored near normoglycemia within 3-4 weeks. The detection of human C-peptide, 1155±165 pM in blood serum of experimental mice demonstrate the efficacy of our differentiation approach. CONCLUSIONS: h-ASC is an ideal population of personal stem cells for cell replacement therapy, given that they are abundant, easily available and autologous in origin. Our findings present evidence that h-ASCs could be induced to differentiate into physiologically competent functional islet like cell aggregates, which may provide as a source of alternative islets for cell replacement therapy in type 1 diabetes

Prevalence Of Catastrophic Health Expenditure Due To Out-Of-Pocket Health Care Expenses Among Households With And Without Chronic Illness In An Urban Area Bangalore, India - A Longitudinal Study

Background:India, one of the economic powerhouses of the world, is lacking in health development. And it is facing ‘Triple burden of disease’. Indians have one of highest proportion of out-of –pocket (OOP) health expenses. Salient reasons are poor quality public health care, costly private care and lack of health insurance. This has led to catastrophic health expenditure (CHE). Another contributor to this CHE is the chronic illness which require long-term follow-up. It is estimated that catastrophic health expenditure impoverishes 3.3% of Indians every year.  This study was undertaken with an aim to estimate the prevalence of catastrophic health expenditure.Methods:A longitudinal study with one year follow-up period was conducted among 350 households of an urban area in Bangalore city. Simple random sampling method was used to select the study sample. Data collection done using pre-tested, semi-structured questionnaire by interview method.Results:Chronic illness mean health expenditure was 1155.67 INR. 56.09% of the direct cost was spent on drugs. In acute illness, mean health expenditure was 567.45 INR. 59.54% of the direct cost was spent on drugs. 48 (14.86%) of the households experienced CHE in the one year. Statistically significant association was found between socio-economic status and catastrophic health expenditure. 85.42% of the households who experienced CHE had a member with chronic illness in it.Conclusion:Reducing the financial burden of high health care expenses is possible by improving the government health care system, free quality regular supply of medications to chronic disease patients and also to improve the beneficiaries under insurance schemes. Keywords:Government health care, financial burden, direct costs

A REVIEW OF COMPLEXITIES OF DISSOCIATIVE IDENTITY DISORDER

<p><i>The complicated mental health disorder known as dissociative identity disorder(DID), originally calledMultiple Personality Disorder, is defined by the existence of two or more separate identities or personalitystates within an individual. Every identityhas a distinct set of behaviour, recollections, and worldviews.These personalities frequently take charge of a person'sbehaviour and may or may not be aware of oneanother. Chronic,severe trauma, especially in early childhood, is usually linked to the beginning of DID. Becausethere is a break in the regular integration of consciousness, memory, and identity, it is classified as a dissociative disorder. Due to DID's covert natureand symptoms that can coincide with those of other mental health issues, diagnosing it can be difficult. mostly for treatment include ongoing psychotherapy with the goal of combining the several identities into a single, coherent sense of self. A key component of treatment is attending to any co-occurring mental health conditions, such as anxiety, depression, or post-traumatic stressdisorder. The fundamental processes and efficacious therapies for DID are still being investigated. Helping people with DID enjoy happy, productive lives requires a thorough and caring approach to treatment. For those impacted by this illness, friends, family,and mental health experts' understanding and support are crucialelements of the recovery process.</i></p&gt