Behavioural risk factors associated with oral cancer: assessment and prevention in primary care dental practices in Scotland

The incidence of oral cancer continues to rise in the UK and in Scotland, with a steady increase in oral cavity cancer rates and a rapid increase in oropharyngeal cancer rates in the last decade. These rates are projected to increase further over the next decade, so there is a pressing need to optimise oral cancer prevention strategies. Tobacco and alcohol use are recognised as the major modifiable risk factors for developing oral cancer (both oral cavity and oropharyngeal). In addition, there is a significant increased risk for oral cancer among lower socioeconomic groups, males, and older age groups. Recently there has been recognition of the role of human papillomavirus in the aetiology of oropharyngeal cancers. The major behavioural risk factors (tobacco and alcohol) implicated in oral cancer risk are also associated with a wide range of diseases affecting oral and general health and are thus termed ‘common risk factors’, increasing the public health benefit should they be tackled. Given the pivotal role in oral cancer and wider disease prevention of reducing tobacco and alcohol use, there is a clear need to optimise the role of primary care dental professionals in delivering behavioural interventions. However, there are uncertainties about the best evidence for particular strategies and approaches to assess risk factors, advise and/or refer in the dental practice setting, with a particular lack of clarity in terms of the specific form and content of such interventions (for example: duration, tailoring to need, who delivers). In addition, the barriers and facilitators to implementation in primary care dental practice - from both the dental professional and patient perspectives - is relatively under-explored. This thesis describes studies undertaken to address these gaps in the knowledge and evidence-base. First a systematic overview was undertaken of systematic reviews and published (international) clinical guidelines. This aimed to identify the evidence on the best practice for the assessment of the major behavioural risk factors associated with oral cancer and for delivering effective behaviour change preventive interventions (in relation to, for example: advice, counselling, signposting/referral to preventive services) by dental professionals in primary care dental practice setting. This evidence was then explored via a study in primary care dental practices in Scotland utilising qualitative in-depth interviews with dental professionals, to identify barriers and facilitators to implementation, and to gather suggestions to inform the development of interventions to support dental professionals in delivering prevention. Finally, a small qualitative survey of patients attending primary care dental practice was conducted to explore barriers, facilitators, and acceptability of risk factor assessment and preventive interventions from the patients’ perspective. The overview shows a lack of direct evidence from the dental practice setting (one high-quality systematic review relating to tobacco prevention and none relating to alcohol). However, relatively strong evidence and recommendations from other primary care (medical/pharmacy) settings were identified and synthesised, which could potentially be adapted and adopted by dental professionals. Overall the findings show that robust risk factor assessment is an important first step in any prevention intervention. There is a clear indication of the effectiveness of a “brief”, in-person, motivational intervention for sustained tobacco abstinence and reduced alcohol consumption. The lack of detail particularly in relation to duration made it difficult to make a conclusion regarding precise specification of the duration of element of the “brief” interventions. For tobacco users, though longer (10-20 minutes) and intensive (more than 20 minutes, with follow-up visits) interventions have shown to be effective in increasing quit rates compared to no intervention, very brief (less than 5 minutes) interventions in a single session also showed comparable effectiveness to the longer brief or intensive interventions. While, for alcohol users, 10-15 minutes multi-contact interventions were most effective, compared to no intervention or very brief intervention or intensive intervention; brief interventions of 5 minutes duration were also reported to be equally effective. Thus, very brief or brief advice of up to 5 minutes, should be trialled for tobacco and alcohol respectively in a dental practice setting, tailored to patient motivational status. Exploring use of the dental team is supported, as effectiveness was generally independent of primary care provider (i.e. general practice physician or nurse). The qualitative studies on feasibility showed time and resources to be the major barriers from the dental professional perspective. Dental professionals also reported social barriers for a) using cancer as a term to frame preventive consultations and b) in delivering alcohol advice which may not be welcome by patients. Professionals were willing to receive training to overcome confidence issues in approaching behavioural aspects of both main risk factors. Patients however generally supported explicit conversations on oral cancer, and were amenable to alcohol as well as smoking advice, provided their stage-of-change (motivational readiness) was incorporated. The use of formal risk assessment tools to frame discussions was broadly supported by patients and professionals alike. Recommendations are made for testing a model of preventive consultation that draws from this best available evidence and addresses barriers for professionals and patients alike to help shape practice and support this important area of public health going forward

Assessment and prevention of behavioural and social risk factors associated with oral cancer: protocol for a systematic review of clinical guidelines and systematic reviews to inform primary care dental professionals

Background: Tobacco and alcohol are recognised as the major risk factors for both oral cavity (mouth) and oropharyngeal (throat) cancers, with increasing acceptance of the role of human papillomavirus (HPV) in the aetiology of oropharyngeal cancers. In addition, there is a significant increased risk for oral cancer among lower socioeconomic groups, males and older age groups. There is a growing evidence for the potential role of primary care professionals in smoking cessation and reducing alcohol-related harm. However, there are uncertainties about the best approaches/strategies to assess risk factors associated with oral cancer, effective components of preventive interventions for behaviour change and implementation strategies in primary care dental settings. Thus, in order to contribute to the prevention of oral cancer effectively, dental professionals need to assess patients on the major risk factors (tobacco, alcohol and HPV/sexual behaviours) and deliver appropriate prevention, taking into account the patient’s sociodemographic context. Aim: The study aims to synthesise evidence on the best practice for undertaking an assessment of major behavioural risk factors associated with oral cancer and delivering effective behaviour change preventive interventions (e.g. advice, counselling, patient recall, signposting/referral to preventive services) by dental professionals in primary care dental settings. Method: The study involves a systematic review and evidence appraisal. We will search for clinical guidelines and systematic reviews from the following databases: Cochrane Library, Ovid MEDLINE, EMBASE, Web of Science, PsychINFO, PubMed, TRIP and Google Scholar. We will also search websites of professional organisations/agencies and bibliographies/reference lists of selected papers. Quality will be assessed with the AGREE II (Appraisal of Guidelines for Research & Evaluation II) instrument for included clinical guidelines and the AMSTAR (A Measurement Tool to Assess Systematic Reviews) and ROBIS instruments for included systematic reviews. The best practice evidence will be assessed via a narrative synthesis of extracted data, considering publication quality. Discussion: This systematic review will synthesise evidence on the best practice for oral cancer risk factor assessment and prevention and evaluate the relationship between available clinical guidelines and the review evidence base. This collation of evidence will be useful for making recommendations for future intervention, research and guideline development

Oral Cancer Prevention: Overview of Systematic Reviews and Clinical Guidelines

No abstract available

A convenient one-pot preparation of <i style="">N</i>-substituted thioamides

1225-1228A convenient one-pot preparation of N-substituted thioamides from acyl halides, amines and H2O/PSCl3/Et3N in good to excellent yield has been reported through a solvent-free, microwave assisted method

Systematic overview of systematic reviews and clinical guidelines: assessment and prevention of behavioural risk factors associated with oral cancer to inform dental professionals in primary care dental practices

Aims/objectives: Tobacco and alcohol are recognised as the major modifiable risk factors for oral cancer, the incidence of which is rising globally and predicted to increase. This paper aimed to: 1) appraise and synthesise best practice evidence for assessing the major behavioural risk factors for oral cancer and delivering behaviour change interventions (for example, advice, counselling, signposting/referral to preventive services); and 2) assess appropriateness for implementation by dental professionals in primary care. Methods: A systematic overview was undertaken of systematic reviews and international clinical guidelines. This involved: systematically searching and collating the international literature on assessing oral cancer risk and delivering preventive interventions within primary care; quality appraising and assessing the risk of bias using validated tools; synthesising the evidence for best practice; and assessing application of key findings to the dental setting. Results and conclusions: There is clear evidence for the effectiveness of a 'brief', in-person, motivational intervention for sustained tobacco abstinence or reduced alcohol consumption, following risk factor assessment. Evidence for combined behavioural interventions is lacking. There is no firm conclusion with regards to optimal duration of brief interventions (range 5-20 minutes). For tobacco users, longer (10-20 minutes) and intensive (more than 20 minutes, with follow-up visits) interventions are more effective in increasing quit rates compared to no intervention; very brief (less than five minutes) interventions in a single session show comparable effectiveness to the longer/more intensive interventions. For alcohol users, 10-15-minute multi-contact interventions were most effective, compared to no intervention or very brief (less than five minutes) intervention or intensive intervention; brief interventions of five-minute duration were equally effective. There is limited direct evidence from the dental practice setting (one high-quality systematic review relating to tobacco prevention and none relating to alcohol). Thus, very brief, or brief advice of up to five minutes, should be trialled for tobacco and alcohol respectively in a dental practice setting, after risk assessment tailored to patient motivational status. Exploring delivery by the dental team is supported, as effectiveness was generally independent of primary care provider

Three spacecraft formation control by means of electrostatic forces

This paper focuses on electrostatic orbital control in formation flying by using switching strategies for charge distribution. Natural and artificial charging effects are taken into account, and limits in charging technology and in power requirements are also considered. The case of three spacecraft formation, which is intrinsically different and more difficult than the two spacecraft problem often analyzed in literature, has been investigated. A Lyapunov based global control strategy is presented and applied to perform formation acquisition and maintenance maneuvers, producing as output the required overall charge. Then, a selective and optimized charge distribution process among the satellites is discussed for avoiding charge breakdowns to surrounding plasma, for reducing the power requirements and the number of charge switches. The results of numerical simulations show the advantages and drawbacks of the selected control technique

Additional file 5: of Assessment and prevention of behavioural and social risk factors associated with oral cancer: protocol for a systematic review of clinical guidelines and systematic reviews to inform Primary Care dental professionals

Data extraction form- details of information to be extracted from systematic reviews and clinical guidelines has been uploaded. (DOCX 20.7 kb

Additional file 1:

The PRISMA-P 2015 checklist for systematic review protocols has been completed and uploaded. (DOC 83 kb