A representation of Malaysian Malay women identity from a systemic functional perspective

Employing a systemic functional analysis of two selected stories written by two different Malay women writers, namely Dina Zaman and Karina Bahrin, this paper investigates the perception of Malay women from two contrasting settings, the metropolitan Kuala Lumpur and a kampong in Terengganu. The study explores the social cultural identity of Malay women within a linguistic context based on an analysis of thematic choice derived from the Hallidayan notion of grammar. In And She Became an Angel (Dina Zaman), suggesting a subordinated female identity in a Malay kampong context, findings derived from the clausal analysis concluded that the main protagonist, Mandak successfully transcended herself from a victimized role into a heroin at the end of the story. She eventually had become an angel in a fire to embrace the only one thing of her life. However, in A Subtle Degree of Restraint (Karina Bahrin), Elena and Badariah, the two representations of new Malay women living in the cosmopolitan Kuala Lumpur, encountered subtle feelings of deprivation in their contrasting life conditions through either marriage or barrenness. Applying a Hallidayan framework that looks at thematic choice in the system of Theme and Rheme and the System of Transitivity, this paper justifies its findings from the distribution and the experiential elements of thematic choices in the two short stories from a linguistic spectrum. It also signifies a refreshing approach on literary studies in the MLE

Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore

Funder: National University Cancer Institute, Singapore; FundRef: http://dx.doi.org/10.13039/501100011105Background: Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here, we describe the prevalence of rare variants in PALB2 in a population-based study of 7840 breast cancer cases and 7928 healthy Chinese, Malay and Indian women from Malaysia and Singapore, and describe the functional impact of germline missense variants identified in this population. Methods: Mutation testing was performed on germline DNA (n=15 768) using targeted sequencing panels. The functional impact of missense variants was tested in mouse embryonic stem cell based functional assays. Results: PTVs in PALB2 were found in 0.73% of breast cancer patients and 0.14% of healthy individuals (OR=5.44; 95% CI 2.85 to 10.39, p<0.0001). In contrast, rare missense variants in PALB2 were not associated with increased risk of breast cancer. Whereas PTVs were associated with later stage of presentation and higher-grade tumours, no significant association was observed with missense variants in PALB2. However, two novel rare missense variants (p.L1027R and p.G1043V) produced unstable proteins and resulted in a decrease in homologous recombination-mediated repair of DNA double-strand breaks. Conclusion: Despite genetic and lifestyle differences between Asian and other populations, the population prevalence of PALB2 PTVs and associated relative risk of breast cancer, are similar to those reported in European populations

Monsoon History: Transitivity and the Question of Identity

In this study, we discuss the identity of a StraitsbornChinese poet, Shirley Lim, through a systemic-functionalanalysis of one of her poems, Monsoon History. Focusing on thetransitivity system of the Hallidayan framework, we demonstratehow the poet uses nature to represent her identity, makingherself one with the surroundings. The experiential elements inthe analysis show how the poet, notwithstanding her externalidentity as a Chinese immersed in a mix of cultures andinfluences, uses the description of the weather and naturalsurroundings to project her inner identity with the mother land.Our analysis suggests that the Hallidayan transitivity frameworkis a valuable resource for construing not merely our experience ofthe world, but our ideals at a deeper level

Whose Story? A Systemic Functional Perspective on Mariah

AbstractThrough a systemic functional analysis of Che Husna's Mariah, this paper argues that Mariah is not the protagonist of the story. The study intends to explore the social cultural identity of a Malaysian woman in the linguistic context deriving from the analysis of semantic structure and lexical grammar features. Employing the Hallidayan framework, particularly thematic choice in the system of Theme and Rheme, this paper justifies its findings from the distribution and the experiential elements in these thematic choices. The distribution of thematic choice in the story shows that Mariah, who is supposed to be the Protagonist of the story is indeed an object, a muted shadow, suggesting a subordinated female identity in the Malaysian and Islamic context

Characterisation of protein-truncating and missense variants in PALB2 in 15 768 women from Malaysia and Singapore.

BACKGROUND: Rare protein-truncating variants (PTVs) in partner and localiser of BRCA2 (PALB2) confer increased risk to breast cancer, but relatively few studies have reported the prevalence in South-East Asian populations. Here, we describe the prevalence of rare variants in PALB2 in a population-based study of 7840 breast cancer cases and 7928 healthy Chinese, Malay and Indian women from Malaysia and Singapore, and describe the functional impact of germline missense variants identified in this population. METHODS: Mutation testing was performed on germline DNA (n=15 768) using targeted sequencing panels. The functional impact of missense variants was tested in mouse embryonic stem cell based functional assays. RESULTS: PTVs in PALB2 were found in 0.73% of breast cancer patients and 0.14% of healthy individuals (OR=5.44; 95% CI 2.85 to 10.39, p<0.0001). In contrast, rare missense variants in PALB2 were not associated with increased risk of breast cancer. Whereas PTVs were associated with later stage of presentation and higher-grade tumours, no significant association was observed with missense variants in PALB2. However, two novel rare missense variants (p.L1027R and p.G1043V) produced unstable proteins and resulted in a decrease in homologous recombination-mediated repair of DNA double-strand breaks. CONCLUSION: Despite genetic and lifestyle differences between Asian and other populations, the population prevalence of PALB2 PTVs and associated relative risk of breast cancer, are similar to those reported in European populations