723 research outputs found
Oriëntatie en zelfbestemming. Existentiële psychotherapie als leidraad voor een existentieel-fenomenologisch verhaal over humanistische geestelijke begeleiding
In deze scriptie onderzoek ik welke inhoudelijke en methodische elementen uit de existentiële psychotherapie relevant en bruikbaar zijn voor het humanistisch geestelijk werk en stel ik voor het existentialistische perspectief op het HGW verder uit te werken. Aan de basis van dit zogenaamde existentieel-fenomologische verhaal over HGW, plaats ik het gedachtegoed van Van Praag. Van Praags humanistisch mensbeeld en ideeën over het menselijk functioneren monden uit in een visie op geestelijke begeleiding waarin de cliënt ondersteund wordt in oriëntatie en zelfbestemming.
In mijn scriptie verdiep ik me in vier benaderingen van ‘de existentiële psychotherapie’: de Daseinsanalyse (Boss en Binswanger), de logotherapie (Frankl), de existentieel-humanistische benadering (May, Yalom en Bugental) en de Britse school voor Existentiële Analyse (Van Deurzen en Spinelli). Met name de inzichten met betrekking tot menselijke vrijheid en verantwoordelijkheid, het lijden en de grenzen van het bestaan worden in deze scriptie benoemd als belangrijke aanvullingen voor het HGW. Daarnaast zijn verschillende methodische elementen als relevant aangewezen, zoals inzichten met betrekking tot het aangaan van een ‘echte’ relatie, de verhouding tussen empathie, normativiteit en neutraliteit en het begeleiden van een (her)oriëntatieproces
Intrapleural administration of tumour necrosis factor-alpha (TNFalpha) in patients with mesothelioma: cytokine patterns and acute-phase protein response
村の歴史を調べる : 大字誌の発行に向けて
textabstractPatients with connective tissue disease (CTD) who are prone to developed isolated pulmonary hypertension (PH) are primarily young females with a history of Raynaud's phenomenon associated with an exertional dyspnoea. From the start of the disease, pulmonary function tests show a decreased diffusing capacity for carbon monoxide, while X-ray examination shows no obvious abnormalities such as interstitial fibrosis. All patients show, on electrocardiographic examination, evidence of right axis deviation and right ventricular hypertrophy. It has been suggested that PH is found mostly in patients with systemic scerlosis characterized by the CREST syndrome. The histopathological findings are intimal proliferation, narrowing of the vessel lumen and medial fibrosis. These are not specific for CTD. One would expect more signs of vasculitis. Neither signs of lung fibrosis, nor signs of pulmonary emboli are described
Churg-Strauss Syndrome following PTU Treatment
Propylthiouracil (PTU) is a frequently prescribed drug in the treatment
of hyperthyroidism. The use of PTU is, however, accompanied by numerous potentially
serious side effects including vasculitis. PTU-related vasculitides can present as
haematuria, pulmonary haemorrhage, or cutaneous lesion together with aspecific
symptoms such as fever, myalgia, arthralgia, and fatigue. Cerebral involvement is
seldom observed. We present a 49-year-old female with Graves' disease and
asthma, who developed paresis of the proximal extremities, eosinophilia, pulmonary, and cutaneous lesions following treatment with PTU. A cerebral vasculitis consistent with Churg-Strauss syndrome (CSS) was suspected. Although cerebral involvement is seldom observed with PTU treatment, cerebral vasculitis should be considered in patients developing CNS symptoms
Anaemia of chronic disease in rheumatoid arthritis - Raised serum interleukin-6 (IL-6) levels and effects of IL-6 and anti-IL-6 on in vitro erythropoiesis
Serum and bone marrow from 21 patients with rheumatoid arthritis (RA) were studied in order to establish the pathogenetic role of interleukin-6 (IL-6) in anemia of chronic disease (ACD). Erythroid colony growth, using burst forming units of erythroblasts (BFUe) as a parameter, was impaired in ACD and not in nonanemic RA controls. Serum IL-6 was elevated in ACD and it correlated well with parameters of disease activity such as erythrocyte sedimentation rate and C-reactive protein. IL-6 addition to bone marrow cultures had inconsistent effects while anti-IL-6 addition resulted in impaired erythroid colony growth, suggesting stimulatory effects of IL-6 produced in the medium, which may be masked by simultaneous production of cytokines with suppressive effects. It was concluded that elevated serum IL-6 in ACD reflects disease activity. It probably plays no pathogenetic role in ACD. Its stimulatory effects on erythroid growth might counteract suppressive effects of other interleukins
No detection of macrophage erythropoietin production in bone marrow from rheumatoid arthritis patients with and without anaemia and controls
Intrapleural administration of tumour necrosis factor alpha (TNFα) in patients with mesothelioma: Cytokine patterns and acute-phase protein response
Reducing the Risk of Secondary Lung Cancer in Treatment Planning of Accelerated Partial Breast Irradiation
Purpose: Adjuvant accelerated partial breast irradiation (APBI) results in low local
recurrence risks. However, the survival benefit of adjuvant radiotherapy APBI for low-risk
breast cancer might partially be offset by the risk of radiation-induced lung cancer.
Reducing the lung dose mitigates this risk, but this could result in higher doses to
the ipsilateral breast. Different external beam APBI techniques are equally conformal
and homogenous, but the intermediate to low dose distribution differs. Thus, the risk
of toxicity is different. The purpose of this study is to quantify the trade-off between
secondary lung cancer risk and breast dose in treatment planning and to compare an
optimal coplanar and non-coplanar technique.
Methods: A total of 440 APBI treatment plans were generated using automated
treatment planning for a coplanar VMAT beam-setup and a non-coplanar robotic
stereotactic radiotherapy beam-setup. This enabled an unbiased comparison of two
times 11 Pareto-optimal plans for 20 patie
Systemic toxicity and cytokine/acute phase protein levels in patients after isolated limb perfusion with tumor necrosis factor-alpha complicated by high leakage
BACKGROUND: Since the introduction of high-dose tumor necrosis
factor-alpha (TNFalpha) in the setting of isolated limb perfusion (ILP) in
the clinic, prevention of leakage to the body of the patient is monitored
with great precision for fear of TNF-mediated toxicity. That we observed
remarkably little toxicity in patients with and without leakage prompted
us to determine patterns of cytokines and acute phase proteins in patients
with high leakage and in patients without any leakage. METHODS: TNFalpha,
interleukin (IL)-6, IL-8, C-reactive protein, and secretory
(s)-phospholipase A2 were measured at several time points during and after
(until 7 days) ILP in 10 patients with a leakage to the systemic
circulation varying in percentage from 12% to 65%. As a control, the same
measurements, both in peripheral blood and in perfusate, were performed in
nine patients without systemic leakage. RESULTS: In patients with systemic
leakage, levels of TNFalpha increased during ILP, reaching values to 277
ng/ml. IL-6 and IL-8 peaked 3 hours after ILP with values significantly
higher compared with patients without systemic leakage. C-reactive protein
and s-phospholipase A2 peaked at day 1 in both patient groups,
s-phospholipase A2 with significant higher levels and C-reactive protein,
in contrast, with lower levels in the leakage patients. CONCLUSIONS: High
leakage of TNFalpha to the systemic circulation, caused by a complicated
ILP, led to 10-fold to more than 100-fold increased levels of TNFalpha,
IL-6, and IL-8 in comparison with patients without leakage. The increase
of the acute phase proteins was limited. Even when high leakage occurs,
this procedure should not
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