A microeconomic model for subsidies allocation: The case of Belarus

The paper develops a microeconomic methodological framework that allows approaching subsidy allocation across the types of assets and impact of subsidies on agricultural outputs and profits. The methodology is based on a non-parametric production frontier estimation. The empirical application is made to 1084 Belarusian corporate farms. The results suggest targeting governmental support at grain and milk production. In this case, 4.14 trillion Belarusian roubles of subsidies increase the overall profit of the sample farms by 1.46 trillion. In the case of targeting, the farms with higher overall efficiency are more sensitive to the support and are able to absorb larger amount of subsidies. The opposite is true in the absence of targeting. --Microeconomic model,data envelopment,subsidies,Belarus

Possibility of local pair existence in optimally doped SmFeAsO(1-x) in pseudogap regime

We report the analysis of pseudogap Delta* derived from resistivity experiments in FeAs-based superconductor SmFeAsO(0.85), having a critical temperature T_c = 55 K. Rather specific dependence Delta*(T) with two representative temperatures followed by a minimum at about 120 K was observed. Below T_s = 147 K, corresponding to the structural transition in SmFeAsO, Delta*(T) decreases linearly down to the temperature T_AFM = 133 K. This last peculiarity can likely be attributed to the antiferromagnetic (AFM) ordering of Fe spins. It is believed that the found behavior can be explained in terms of Machida, Nokura, and Matsubara (MNM) theory developed for the AFM superconductors.Comment: 5 pages, 2 figure

Use of iodine and selenium enriched fodder rations for production of fortified young lamb

The article is devoted to preventive measures to eliminate the problem of dysmicroelementosis in order to increase the productivity of young sheep. The article presents the results of studies of the influence of feeding rations on the growth and development of young sheep of the Edilbaev breed, on the level of their meat productivity and the qualitative characteristics of biologically fortified lamb. Feed additives based on Yoddar-Zn and DAFS-25 were added to the main ration of lambs at the age of four months, once a day, being added into a fodder mixture with concentrates. For the experiment the herd of lambs was divided to four groups of 25 heads each.The changes in live weight at the age of four, five, six and seven months were analyzed, and it was found that at the age of seven months, the absolute average weight gain in the experimental groups varied from 3.45 kg to 4.49 kg, in the control group it was 3.1 kg, while the largest live weight gain was recorded in group III which received both feed additives based on Yoddar-Zn and DAFS-25.There were no significant differences in the parameters of body measurements, with the exception of group III, where the chest circumference increased by 7.2%, and the height of a lamb at the withers increased in average by 8.1%. It was found that group III had the highest meat density coefficient, equal to 3.9, and the cross-sectional area of m. Longissimus dorsi was equal to 13.61 cm2. It was noted that the amount of free amino acids of the lamb group III is 18.8% higher than the meat of the control group. The lamb obtained from the animals of the experimental groups showed a higher protein content and less fat. The ratio of water to protein in all samples was slightly higher than 3.7, which corresponds to the Federa number for meat raw materials. Enriching the rations of the Edilbaevskoy sheep with feed additives Yoddar-Zn and DAFS-25 promotes the stimulation of growth and development of animals, increases the productivity and nutritional value of lamb

Structure–property relationships in halogenbenzoic acids: Thermodynamics of sublimation, fusion, vaporization and solubility

© 2016 Elsevier LtdTemperature dependences of vapor pressures for 2-, 3-, and 4-bromobenzoic acid, as well as for five isomeric bromo-methylbenzoic acids were studied by the transpiration method. Melting temperatures and enthalpies of fusion for all isomeric bromo-methylbenzoic acids and 4-bromobenzoic acid were measured with a DSC. The molar enthalpies of sublimation and vaporization were derived. These data together with results available in the literature were collected and checked for internal consistency using a group-additivity procedure and results from X-ray structural diffraction studies. Specific (hydrogen bonding) interactions in the liquid and in the crystal phase of halogenbenzoic acids were quantified based on experimental values of vaporization and sublimation enthalpies. Structure-property correlations of solubilities of halogenobenzoic acids with sublimation pressures and sublimation enthalpies were developed and solubilities of bromo-benzoic acids were estimated. These new results resolve much of the ambiguity in the available thermochemical and solubility data on bromobenzoic acids. The approach based on structure property correlations can be applied for the assessment of water solubility of sparingly soluble drugs

Роль методов визуализации для обеспечения безопасности пациента в анестезиологической практике (обзор)

Medical imaging deals with physical examination and visual monitoring the organs and tissues. The main advantage of the imaging is capability to get quick and informative diagnostic data on the state of the main body systems in real time. In addition, imaging system using can reduce the risk of complications during manipulations. In this review, the potential of various imaging techniques, their advantages and disadvantages, and features of their application in anesthesiology are discussed.Медицинская визуализация, как комплекс мер, основанный на применении физических методов обследования и направленный на осуществление зрительного контроля за состоянием исследуемого органа и ткани или изменением его вследствие внешнего воздействия является одной из основ современной безопасной анестезиологической практики. Главным преимуществом визуализации является возможность быстро, информативно, в режиме реального времени получить необходимые диагностические данные о состоянии основных систем организма. Кроме того, ее применение позволяет уменьшить риски развития осложнений при выполнении манипуляций. В настоящем обзоре указаны возможности различных методов визуализации, их положительные и отрицательные стороны, особенности применения

Thermochemistry of halogenobenzoic acids as an access to PC-SAFT solubility modeling

© 2015 Elsevier B.V. Absolute vapor pressures and molar sublimation enthalpies of 2-, 3-, and 4-monohalogenobenzoic acids (halogen = fluorine and iodine) were derived from transpiration measurements. Molar enthalpies of fusion were measured by DSC. Thermochemical data available in the literature were collected, evaluated, and combined with own experimental results in order to recommend sets of sublimation and fusion enthalpies. Further, the recommended data were used to estimate PC-SAFT pure-component parameters. These parameters were applied to predict the solubility of the monohalogenobenzoic acids in water at 298.15 K, yielding satisfying prediction results. This approach proved the capability of PC-SAFT to predict solid-liquid phase equilibria if precise data on sublimation pressures and fusion properties is available

RNA polymerase gate loop guides the nontemplate DNA strand in transcription complexes

Upon RNA polymerase (RNAP) binding to a promoter, the s factor initiates DNA strand separation and captures the melted nontemplate DNA, whereas the core enzyme establishes interactions with the duplex DNA in front of the active site that stabilize initiation complexes and persist throughout elongation. Among many core RNAP elements that participate in these interactions, the beta' clamp domain plays the most prominent role. In this work, we investigate the role of the beta gate loop, a conserved and essential structural element that lies across the DNA channel from the clamp, in transcription regulation. The gate loop was proposed to control DNA loading during initiation and to interact with NusG-like proteins to lock RNAP in a closed, processive state during elongation. We show that the removal of the gate loop has large effects on promoter complexes, trapping an unstable intermediate in which the RNAP contacts with the nontemplate strand discriminator region and the downstream duplex DNA are not yet fully established. We find that although RNAP lacking the gate loop displays moderate defects in pausing, transcript cleavage, and termination, it is fully responsive to the transcription elongation factor NusG. Together with the structural data, our results support a model in which the gate loop, acting in concert with initiation or elongation factors, guides the nontemplate DNA in transcription complexes, thereby modulating their regulatory properties

Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance

Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant mechanism of resistance to macrolides is dimethylation of the 23S rRNA nucleotide A2058, located in the drug-binding site, a reaction catalyzed by Erm-type rRNA methyltransferases. Here, we present the crystal structure of the Erm-dimethylated 70S ribosome at 2.4 Å resolution, together with the structures of unmethylated 70S ribosome functional complexes alone or in combination with macrolides. Altogether, our structural data do not support previous models and, instead, suggest a principally new explanation of how A2058 dimethylation confers resistance to macrolides. Moreover, high-resolution structures of two macrolide antibiotics bound to the unmodified ribosome reveal a previously unknown role of the desosamine moiety in drug binding, laying a foundation for the rational knowledge-based design of macrolides that can overcome Erm-mediated resistance

Structure of RNA polymerase bound to ribosomal 30S subunit

In bacteria, mRNA transcription and translation are coupled to coordinate optimal gene expression and maintain genome stability. Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and the translational machinery. We present cryo-EM structures of E. coli RNAP core bound to the small ribosomal 30S subunit. The complex is stable under cell-like ionic conditions, consistent with functional interaction between RNAP and the 30S subunit. The RNA exit tunnel of RNAP aligns with the Shine-Dalgarno-binding site of the 30S subunit. Ribosomal protein S1 forms a wall of the tunnel between RNAP and the 30S subunit, consistent with its role in directing mRNAs onto the ribosome. The nucleic-acid-binding cleft of RNAP samples distinct conformations, suggesting different functional states during transcription-translation coupling. The architecture of the 30S*RNAP complex provides a structural basis for co-localization of the transcriptional and translational machineries, and inform future mechanistic studies of coupled transcription and translation