Thoracic metastasis in advanced ovarian cancer: comparison between computed tomography and video-assisted thoracic surgery.

OBJECTIVE: To determine which computed tomography (CT) imaging features predict pleural malignancy in patients with advanced epithelial ovarian carcinoma (EOC) using video-assisted thoracic surgery (VATS), pathology, and cytology findings as the reference standard. METHODS: This retrospective study included 44 patients with International Federation of Obstetrics and Gynecology (FIGO) stage III or IV primary or recurrent EOC who had chest CT ≤30 days before VATS. Two radiologists independently reviewed the CT studies and recorded the presence and size of pleural effusions and of ascites; pleural nodules, thickening, enhancement, subdiaphragmatic tumour deposits and supradiaphragmatic, mediastinal, hilar, and retroperitoneal adenopathy; and peritoneal seeding. VATS, pathology, and cytology findings constituted the reference standard. RESULTS: In 26/44 (59%) patients, pleural biopsies were malignant. Only the size of left-sided pleural effusion (reader 1: rho=-0.39, p=0.01; reader 2: rho=-0.37, p=0.01) and presence of ascites (reader 1: rho=-0.33, p=0.03; reader 2: rho=-0.35, p=0.03) were significantly associated with solid pleural metastasis. Pleural fluid cytology was malignant in 26/35 (74%) patients. Only the presence (p=0.03 for both readers) and size (reader 1: rho=0.34, p=0.04; reader 2: rho=0.33, p=0.06) of right-sided pleural effusion were associated with malignant pleural effusion. Interobserver agreement was substantial (kappa=0.78) for effusion size and moderate (kappa=0.46) for presence of solid pleural disease. No other CT features were associated with malignancy at biopsy or cytology. CONCLUSION: In patients with advanced EOC, ascites and left-sided pleural effusion size were associated with solid pleural metastasis, while the presence and size of right-sided effusion were associated with malignant pleural effusion. No other CT features evaluated were associated with pleural malignancy

INTERPERSONAL SPACE OF VITAL FUNCTIONS AS THE SYSTEM OF MINDFULNESS DEVELOPMENT

Исследование, представленное в статье, призвано внести вклад в решение важной проблемы социальной адаптации личности на этапах профессионального становления, развития и совершенствования. В связи с этим, перед современной системой профессионального образования возникает ряд вопросов, связанных, в первую очередь, с эффективностью работы в области взаимодействия всех субъектов профессионального образования. Развитие личностной осознанности – важная задача личностного совершенствования. Проблема развития осознанности – ключевой аспект развития Личности. Понятие «Осознание» как совокупность процесса и результата («осознанность») интеграции информационного потенциала, проявленное как целостная структура отдельных интеграционных потенциалов в индивидуальном свободном сознании.Цель работы заключается в разработке и апробации метода IAI (интроспективный анализ интерперсоны) жизнедеятельности человека, который является инновационным инструментом мониторинговых исследований профессионально-педагогических проблем и задач, а также отправной точкой для создания унифицированной системы развития осознанности с целью профилактики внутриличностных и межличностных конфликтов.Результаты исследования показали, что в процессе применения метода IAI (интроспективный анализ интерперсоны) повысился уровень понимания к педагогическим требованиям, проявились явные формы осознанного поведения. Взаимоотношения людей в процессе эксперимента строятся на основе осознанного восприятия личности партнера, с четким осознанием именно коммуникативной цели, полноценной ответственностью за коммуникативный процесс и твердым намерением решить поставленную коммуникативную задачу.The study presented in the article is intended to contribute to the solution of the important problem of social adaptation of a person at the stages of professional development and improvement. In this regard, a number of questions arise in front of the modern system of vocational education related to the effectiveness of work in the field of interaction of all subjects of vocational education. Development of personal mindfulness is an important task of personal development. The problem of development of mindfulness is a key aspect of personal development. The concept of “Mindfulness” as a set of process and result (“mindfulness”) of the integration of information potential, manifested as an integral structure of individual integration potentials in the individual free consciousness.The aim of the work is to develop and test the IAI method (introspective analysis of interpersons) of human life, which is an innovative tool for monitoring research of professional and pedagogical problems and tasks, as well as a starting point for creating a unified system for developing awareness to prevent intrapersonal and interpersonal conflicts.The results of the study showed that in the process of applying the method of IAI (introspective analysis of interpersonal) the level of understanding of pedagogical requirements increased, manifested clear forms of conscious behavior. Relationships between people in the experiment are based on a conscious perception of the partner’s personality, with a clear understanding of the communicative purpose, full responsibility for the communicative process and a firm intention to solve the communicative tasks

Ambiente educacional como recurso de desenvolvimento para o processo de aprendizagem

Following overseas examples, educational institutions in Russia are trying to interact with other organizations implementing practical competence approach. The relevance of the topic lies in the fact that modern educational environment is constantly changing both due to the dynamics of everyday and professional conditions. Due to competence approach constant monitoring and new resources are required for the development of each subject in this educational environment. The goal of the work is to create means for open social and educational environment realization which allows achieving positive results for all participants in the project. In this article, the authors raise the issue of modern educational environment creation as a resource for each subject of the educational process development.The article attempts to improve students’, teachers’ and others participants’ interested in educational environment development interaction. We try to achieve a qualitatively new level of participants’ skills and competencies development in this process. For this, analysis of the essence and structure of educational process in a higher educational institution was carried out. After that, the authors propose, within the framework of a project implemented by Nizhny Novgorod State Pedagogical University on the organization and development of the social and educational environment, to conduct special computer literacy courses for the elderly. The courses offered combine the activities of a large number of people who, working for a common result, achieve the development of individual qualities. The results obtained are the basis for further improvement of educational environment.Siguiendo ejemplos en el extranjero, las instituciones educativas en Rusia están tratando de interactuar con otras organizaciones implementando un enfoque de competencia práctica. La relevancia del tema radica en el hecho de que el entorno educativo moderno está cambiando constantemente debido a la dinámica de las condiciones cotidianas y profesionales. Debido al enfoque de competencia, el monitoreo constante y nuevos recursos son necesarios para el desarrollo de cada asignatura en este entorno educativo. El objetivo del trabajo es crear medios para la realización de un entorno social y educativo abierto que permita lograr resultados positivos para todos los participantes en el proyecto. En este artículo, los autores plantean el tema de la creación de un entorno educativo moderno como un recurso para cada tema del desarrollo del proceso educativo.El artículo intenta mejorar la interacción entre los estudiantes, los maestros y otros participantes interesados en el desarrollo del entorno educativo. Intentamos alcanzar un nivel cualitativamente nuevo de desarrollo de habilidades y competencias de los participantes en este proceso. Para ello, se realizó un análisis de la esencia y estructura del proceso educativo en una institución de educación superior. Posteriormente, los autores proponen, en el marco de un proyecto implementado por la Universidad Pedagógica Estatal Nizhny Novgorod sobre la organización y el desarrollo del entorno social y educativo, realizar cursos especiales de alfabetización informática para personas mayores. Los cursos ofrecidos combinan las actividades de un gran número de personas que, trabajando por un resultado común, logran el desarrollo de cualidades individuales.Na sequência de exemplos no exterior, instituições educacionais na Rússia estão tentando interagir com outras organizações implementando uma abordagem de competência prática. A relevância do tema reside no fato de que o ambiente educacional moderno está em constante mudança, tanto devido à dinâmica das condições cotidianas e profissionais. Devido à abordagem de competência, monitoramento constante e novos recursos são necessários para o desenvolvimento de cada disciplina nesse ambiente educacional. O objetivo do trabalho é criar meios para a realização de um ambiente social e educacional aberto que permita alcançar resultados positivos para todos os participantes do projeto. Neste artigo, os autores levantam a questão da criação de ambientes educacionais modernos como recurso para cada sujeito do processo de desenvolvimento educacional.O artigo tenta melhorar a interação dos alunos, professores e outros participantes interessados na interação do desenvolvimento do ambiente educacional. Tentamos alcançar um nível qualitativamente novo de desenvolvimento de habilidades e competências dos participantes neste processo. Para isso, foi realizada a análise da essência e estrutura do processo educacional em uma instituição de ensino superior. Em seguida, os autores propõem, no âmbito de um projeto implementado pela Universidade Pedagógica Estadual Nizhny Novgorod, a organização e desenvolvimento do ambiente socioeducacional, para a realização de cursos especiais de alfabetização em informática para idosos. Os cursos oferecidos combinam as atividades de um grande número de pessoas que, trabalhando por um resultado comum, alcançam o desenvolvimento de qualidades individuai

Water-soluble hybrid materials based on {Mo₆X₈}⁴⁺ (X = Cl, Br, I) cluster complexes and sodium polystyrene sulfonate

Development of water-soluble forms of octahedral molybdenum clusters {Mo₆X₈}⁴⁺ (X = Cl, Br, I) is strongly motivated by the tremendous potential that these complexes have for biological applications, namely as agents for bioimaging and photodynamic therapy. In these work we report the first water-soluble hybrid materials, which represent sodium polystyrene sulfonate doped by molybdenum clusters, and evaluation of their photophysical and biological properties (dark and photoinduced cytotoxicity and cellular uptake) with the use of cervical cancer (HeLa) and human epidermoid larynx carcinoma (Hep-2) cell-lines as models

Bacterial Nitric Oxide Extends the Lifespan of C. elegans

SummaryNitric oxide (NO) is an important signaling molecule in multicellular organisms. Most animals produce NO from L-arginine via a family of dedicated enzymes known as NO synthases (NOSes). A rare exception is the roundworm Caenorhabditis elegans, which lacks its own NOS. However, in its natural environment, C. elegans feeds on Bacilli that possess functional NOS. Here, we demonstrate that bacterially derived NO enhances C. elegans longevity and stress resistance via a defined group of genes that function under the dual control of HSF-1 and DAF-16 transcription factors. Our work provides an example of interspecies signaling by a small molecule and illustrates the lifelong value of commensal bacteria to their host

CRITERIA FOR DEVELOPMENT OF THE PERSONAL POTENTIAL OF SPECIALISTS

Актуальность настоящей работы обусловлена потребностями в исследованиях критериев развития личностного потенциала специалистов в условиях современных тенденций развития профессионального образования. В процессе исследования авторами определено, что личностный потенциал специалиста, обладающего сформированными общепрофессиональными и профессиональными компетенциями состоит из ценностных ориентаций, психологических свойств личности, психологических и социальных особенностей, профессионально-значимых личностных качеств, трудового потенциала и творческой активности. Личностный потенциал предполагает способность не только к профессиональным формам творчества, но и к социальным, потребность в которых в условиях глубоких политических и социально-экономических преобразований в нашем обществе становится все более очевидной. Определено, что современные тенденции развития профессионального образования предопределяют создание нового стереотипа личности специалиста, умеющего уметь мысленно опережать реальные производственные ситуации, анализировать их и принимать своевременные компетентные, профессиональные зрелые решения.In the process of research, the authors found that the personal potential of a specialist with well-formed professional and professional competences, consisting of value orientations, psychological properties of the individual, psychological and social characteristics, professionally significant personal qualities, labor potential and creative activity. Personal potential implies the ability not only to professional forms, but also to social ones, but in those cases when they become more and more obvious. It is determined that modern trends in the development of vocational education, skills, abilities, abilities, abilities, abilities and skills

ФОРМИРОВАНИЕ ЭКОЛОГИЧЕСКОЙ НАПРАВЛЕННОСТИ МИРОВОЗЗРЕНИЯ СТУДЕНТОВ

The motivational core of the formation of the environmental orientation of a professional is a strategic factor in the development of personal potential, determining the role in a qualified professional activity, and is the product of this activity.The aim of the work is to study the ways of formation of environmental orientation of student’s mentality during training.The methodological basis of the study was a comparative analysis, empirical methods and modeling.The authors consider the practice-oriented professional ecological education of students as one of the system methods of ecological education.The study of the ecological orientation of student’s mentality suggests that modern trends in the development of vocational education predetermine the creation of a new personality stereotype of a specialist who is able to mentally anticipate real environmental situations of a situation, analyze them and make timely, competent and professional decisions.Мотивационное ядро формирования экологической направленности профессионала является системообразующим фактором развития личностного потенциала, определяя роль в квалифицированной профессиональной деятельности, и является продуктом этой деятельности.Цель работы заключается в исследовании способов формирования экологической направленности обучающихся в процессе профессиональной подготовки.Методической основой исследования послужили сравнительный анализ, группа эмпирических методов, моделирование.Авторами рассматривается практико-ориентированное профессионально-экологическое образование студентов, как один из системных методов экологического образования.Результаты исследования сформированности экологической направленности мировоззрения обучающихся позволяет говорить о том, что современные тенденции развития профессионального образования предопределяют создание нового стереотипа личности специалиста, умеющего мысленно опережать реальные экологические ситуации, анализировать их и принимать своевременные компетентные, профессиональные зрелые решения

DESCRIPTION OF ATTENTION FUNCTION FEATURES IN ARCTIC POPULATION

Abstract. The states of the Cold area similarly unfavorably influence the condition of higher types of willfulconsideration among all inhabitants, leveling the factor of individual contrasts. An individual's stay in the Ice locale is joined by change of the utilitarian asymmetry of the cerebrum and a lessening in the ordinary capacity of the overwhelming side of the equator. The got discoveries recommend a particular right asymmetry of consideration among agents of indigenous populace of the Cold district. The agents of the non-indigenous populace with age and an expansion in the term of their stay in the Ice locale altogether increment the extent of individuals with a fractional kind of consideration asymmetry, which additionally mirrors the difference in hemispheric collaboration, because of the expanded impact of the correct half of the globe. The got information are reliable with the suppositions about the insecurity of practical asymmetry and the likelihood of its change affected by distressing occasions, which incorporatethe general population's stay in the Ice locale.Keywords: attention function, the Arctic Region, encephalic asymmetry, aborigines of the North

Synthesis of Molecular Dodecanuclear Carbon-centered Rhenium Cluster Re12CS17 and its Conducting Properties

The unique dodecanuclear cluster compound Re12CS17 was prepared and studied by X-ray, complex impedance method and density functional theory (DFT). The compound is amorphous, possesses semiconducting properties. Computer simulations showed that the Re and S atoms at the external borders of the neighboring molecules Re12CS17 can form sufficiently strong Re•••S intermolecular bonds, similar to the Mo•••S intermolecular bonds of cuboctahedron Mo6S8 molecules in the Chevrel phases. (doi: 10.5562/cca1973