65 research outputs found

    Interleukin-6 receptor pathways in abdominal aortic aneurysm

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    We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo. Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach

    Role of peptidases in bradykinin-induced increase in vascular permeability in vivo.

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    Cellular and Intercellular Transport Pathways in Exchange Vessels

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