Das glagolitische Missale von Kopenhagen

Das glagolitische Missale von Kopenhagen Verf. beschreibt, datiert und ubiziert in diesem Aufsatz ein Missale Romanum lingua slavonica charactere glagolitico, das sich in der Königlichen Bibliothek zu Kopenhagen befindet. (Ny kongelig Samling 41 b, 2°). - Abschnitt I berichtet von den Umständen, unter welchen dieses Missale hafniense (Mh) 1839 aus der Hofbibliothek Wien nach Dänemark gereit. Es wird besprochen, wie eine Notiz, die im Jahre 1499 von dem bekannten Schreiber Simun Greblić in das Mh eingeführt wurde, zeigt dass sich der Kodex damals in Roč in Istrien befand. - Abschnitt II zeigt den Inhalt und den Umfang des Messbuchs. - Abschnitt III enthält eine paläographische Charakteristik, die es zusammen mit des Paschaltafel im Mh wahrscheinlich macht, dass der Kodex zu Ende des 14. Jahrhunderts zu datieren ist. Schon 1839, als Mh in dänischen Besitz überging, hatte man mit "saec. XIV" die Handschrift datiert. - Im Abschnitt IV versucht Verf. auf Grund einer Reihe von sprachlichen, vor allem phonetisch-dialektalen Erscheinungen im Texte darzulegen, dass das Mh wahrscheinlich auf Krk geschrieben oder jedenfalls von Mundarten dieser Insel beeinflusst wurde. Sowohl dies als auch die spätere Überführung nach Istrien spiegelt sich, so scheint es, in dem Kalender des Messbuchs ab. - Über die Art der im Mh enthaltenen Texte wird im Abschnitt V erwähnt, dass sie in einigen Punkten gewisse Ähnlichkeiten mit den Kodexen des Schreibers Bartol aus der Krbava haben, jedoch ohne dass es möglich wäre, auf Grund dieser Übereinstimmunegn das Mh demselben Bartol zuzuschreiben. Ferner wird kurz gezeit, dass der Messkanon der Handschrift (fragmentarisch) in wichtigen Punkten mit dem Canon missae des Vatikaner Kodex\u27 aus dem Beginn des 14. Jahrhunderts übereinstimmt; ihre Bibeltexte aber sind - wie auch die Lektionen in Novaks Messbuch oder im Ročer Kodex - gewissermassen einer Revision unterworfen, wobei man sich an die Vulgata oder das lateinische Missale gehalten hat. Man spürt demnach jedenfalls zwei Traditionen in dem Kopenhagener Messbuch

Immune checkpoint inhibitor treatment and ophthalmologist consultations in patients with malignant melanoma or lung cancer—A nationwide cohort study

SIMPLE SUMMARY: Immune checkpoint inhibitors are increasingly being used for treating advanced malignant cutaneous melanoma and lung cancer. Immune-related side effects in multiple organs are common but the frequencies of ophthalmic side effects in national cohorts of unselected patients are undescribed. This study estimated frequencies of first-time ophthalmologist consultations and inflammatory conditions in consecutive patients with malignant melanoma or lung cancer treated with immune checkpoint inhibitors in Denmark from 2011–2018. The one-year risks of first-time consultation and ocular inflammation were 6% and 1%, respectively. These numbers were increased compared with patients with the same type of cancer who were not treated with immune checkpoint inhibitiors. ABSTRACT: Purpose: To estimate the frequency of first-time ocular events in patients treated with immune checkpoint inhibitors (ICI). Methods: Patients with cancer in 2011–2018 in Denmark were included and followed. The outcomes were first-time ophthalmologist consultation and ocular inflammation. One-year absolute risks of outcomes and hazard ratios were estimated. Results: 112,289 patients with cancer were included, and 2195 were treated with ICI. One year after the first ICI treatment, 6% of the patients with cancer, 5% and 8% of the lung cancer (LC) and malignant cutaneous melanoma (MM) patients, respectively, had a first-time ophthalmologist consultation. The risk of ocular inflammation was 1% (95% confidence interval (CI) 0.4–1.2). Among patients with MM, ICI was associated with ocular inflammation in women (HR 12.6 (95% CI 5.83–27.31) and men (4.87 (95% CI 1.79–13.29)). Comparing patients with and without ICI treatment, the risk of first-time ophthalmologist consultation was increased in patients with LC (HR 1.74 (95% CI 1.29–2.34) and MM (HR 3.21 (95% CI 2.31–4.44). Conclusions: The one-year risks of first-time ophthalmologist consultation and ocular inflammation were 6% and 1%, respectively, in patients treated with ICI. In patients with LC and MM, the risk was increased in patients with ICI compared with patients without ICI

Potassium, chlorine, and sulfur in ash, particles, deposits, and corrosion during wood combustion in a circulating fluidized-bed boiler

The effect of the addition of chlorine and/or sulfur to the fuel on fly ash composition, deposit formation, and superheater corrosion has been studied during biomass combustion in a circulating fluidized-bed boiler. The chlorine (HCl (aq)) and sulfur (SO2 (g)) were added in proportions of relevance for the potassium chemistry. The composition of the bottom and the fly ashes was analyzed. Gas and particle measurements were performed downstream of the cyclone before the convection pass and the flue gas composition was recorded in the stack with a series of standard instruments and an FTIR analyzer. At the position downstream of the cyclone, a deposit probe was situated, simulating a superheater tube. Deposits on the probe and initial corrosion were examined. It is concluded that addition of sulfur and chlorine increases the formation of submicron particles leading to deposition of potassium sulfate and chloride. The results compare well with earlier work based on laboratory-scale experiments concerning effects of chlorine and sulfur on potassium chemistry

Sudden cardiac death among persons with diabetes aged 1-49 years:a 10-year nationwide study of 14 294 deaths in Denmark

Aims The aim of this study was to compare nationwide incidence rate (IR) of sudden cardiac death (SCD) in persons aged 1–49 years with and without diabetes mellitus (DM). Methods and results The study population consisted of all persons in Denmark aged 1–49 years in 2000–09, which equals 27.1 million person-years. All 14 294 deaths in the 10-year period were included. By using the highly descriptive Danish death certificates, 1698 cases of sudden and unexpected death were identified. Through review of autopsy reports, discharge summaries, and the Danish registries, we identified 1363 cases of SCD. The Danish Register of Medicinal Product Statistics was used to identify persons with type 1 DM and type 2 DM. Among the 14 294 decedents, there were 669 with DM, of which 118 suffered SCD (9% of all SCD), making SCD the leading cause of death among young persons with DM. Among those aged 1–35 years, the IR of SCD-DM was 21.9 per 100 000 person-years compared to 2.6 per 100 000 person-years among persons without DM [IR ratio 8.6, 95% confidence interval (CI) 5.8–28.6]. Within the age range 36–49 years, the IR among persons with DM was 119.8 per 100 000 person-years compared to 19.7 per 100 000 person-years among persons without DM (IR ratio 6.1, 95% CI 4.7–7.8). Conclusion We found that young persons with DM aged 1–35 years had >8-fold higher SCD IR compared to young persons without DM. Our study highlights the need for early cardiovascular risk monitoring and assessment in young persons with DM.This work was supported by the Novo Nordisk Foundation, Copenhagen, Denmark [NNFOC140011573]. JS, reciewed salary from the Department of Forensic Medicine, Univiserty of Copenhagen

Ethnic disparities in out-of-hospital cardiac arrest:A population-based cohort study among adult Danish immigrants

BACKGROUND: Ethnicity might impact out-of-hospital cardiac arrest (OHCA) risk, but it has scarcely been studied in Europe. We aimed to assess whether ethnicity influenced the risk of OHCA of cardiac cause in Danish immigrants and its interplay with risk factors for OHCA and socioeconomic status. METHODS: This nationwide study included all immigrants between 18 and 80 years present in Denmark at some point between 2001 and 2020. Regions of origin were defined as Africa, Arabic countries, Asia, Eastern Europe, Latin America, and Western countries. OHCAs with presumed cardiac cause were identified from the Danish Cardiac Arrest Registry. FINDINGS: Overall, among 1,011,565 immigrants, a total of 1,801 (0.2%) OHCAs (median age 64 (Q1-Q3 53–72) years, 72% males) occurred. The age- and sex- standardized (reference: Western countries) incidence of OHCA (/1,00,000 person-years) was 34.6 (27.8–43.4) in African, 34.1 (30.4–38.4) in Arabic, 33.5 (29.3–38.2) in Asian, 35.6 (31.9–39.6) in Eastern European, and 16.2 (9.0–27.2) in Latin American immigrants. When selecting Western origin as a reference, and after adjusting on OHCA risk factors, Arabic (HR 1.18, 95%CI 1.04–1.35; P=0.01), Eastern European (HR 1.28, 95%CI 1.13–1.46; P<0.001), and African origin (HR 1.34, 95%CI 1.10–1.63; P<0.01) were associated with higher risk of OHCA, whereas Latin American origin (HR 0.58, 95%CI 0.35–0.0.96; P=0.03) was associated with lower risk of OHCA. Comparable results were observed when adjusting on education level and economic status. INTERPRETATION: This study emphasizes that ethnicity is associated with OHCA risk, even when considering traditional cardiac arrest risk factors. FUNDING: R Garcia received a grant from the Fédération Française de Cardiologie for his post-doctoral fellowship and this work was supported by the Novo Nordisk Foundation Tandem Programme 2022 (grant# 31364)

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