Migratory movements of rhinoceros auklets in the northwestern Pacific: connecting seasonal productivities

Spatial and temporal variability in marine biological productivity may drive heterogeneity in seasonal resources available for marine animals in temperate waters. Migratory seabirds are expected to adjust their annual cycle of breeding activities and migratory movements to exploit seasonally available resources efficiently. We studied the movement and trophic position of rhinoceros auklets Cerorhinca monocerata breeding at Teuri Island, Japan Sea, during the nonbreeding and early breeding periods over 2 yr. After breeding, the auklets moved northward from the colony to the Sea of Okhotsk, where phytoplankton blooms enhanced biological productivity in autumn. The birds then moved southward to the southwestern Japan Sea (~1470 km from the colony), where major epipelagic fish and squid concentrations have been reported in winter. Stable isotope analyses suggest that the auklets fed on higher-trophic level prey, including fish and/or squid during the autumn and winter nonbreeding periods. The auklets moved northward and returned to the colony in mid-March. During the early breeding period, the birds foraged close to the colony (~380 km) on lower-trophic level prey including fish and/or krill, which were available during the spring phytoplankton bloom. The timing of the return migration does not match with the northward migration of warm-water anchovy, a profitable prey during summer, but may be related to timing the chick-rearing period to correspond with anchovy arrival. We suggest that rhinoceros auklets follow spatial and seasonal changes in prey availability by a distinctive ‘3-step’ migration (first northward, second southward, third northward) in the temperate marine system of the northwestern Pacific

HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

APOBEC3 (A3) family proteins are DNA cytosine deaminases recognized for contributing to HIV-1 restriction and mutation. Prior studies have demonstrated that A3D, A3F, and A3G enzymes elicit a robust anti-HIV-1 effect in cell cultures and in humanized mouse models. Human A3H is polymorphic and can be categorized into three phenotypes: stable, intermediate, and unstable. However, the anti-viral effect of endogenous A3H in vivo has yet to be examined. Here we utilize a hematopoietic stem cell-transplanted humanized mouse model and demonstrate that stable A3H robustly affects HIV-1 fitness in vivo. In contrast, the selection pressure mediated by intermediate A3H is relaxed. Intriguingly, viral genomic RNA sequencing reveled that HIV-1 frequently adapts to better counteract stable A3H during replication in humanized mice. Molecular phylogenetic analyses and mathematical modeling suggest that stable A3H may be a critical factor in human-to-human viral transmission. Taken together, this study provides evidence that stable variants of A3H impose selective pressure on HIV-1

New Technique for Introducing a Surgical Stapler during Robot-Assisted Lobectomy for Lung Cancer

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Analysis of the outer divertor hot spot activity in the protection video camera recordings at JET

Hot spots on the divertor tiles at JET result in overestimation of the tile surface temperature which causes unnecessary termination of pulses. However, the appearance of hot spots can also indicate the condition of the divertor tile surfaces. To analyse the behaviour of the hot spots in the outer divertor tiles of JET, a simple image processing algorithm is developed. The algorithm isolates areas of bright pixels in the camera image and compares them to previously identified hot spots. The activity of the hot spots is then linked to values of other signals and parameters in the same time intervals. The operation of the detection algorithm was studied in a limited pulse range with high hot spot activity on the divertor tiles 5, 6 and 7. This allowed us to optimise the values of the controlling parameters. Then, the wider applicability of the method has been demonstrated by the analysis of the hot spot behaviour in a whole experimental campaign

Improved neutron activation dosimetry for fusion

Neutron activation technique has been widely used for the monitoring of neutron fluence at the Joint European Torus (JET) whereas it is foreseen to be employed at future fusion plants, such as ITER and DEMO. Neutron activation provides a robust tool for the measurement of neutron fluence in the complex environment encountered in a tokamak. However, activation experiments previously performed at JET showed that the activation foils used need to be calibrated in a real fusion environment in order to provide accurate neutron fluence data. Triggered by this challenge, an improved neutron activation method for the evaluation of neutron fluence at fusion devices has been developed. Activation assemblies similar to those used at JET were irradiated under 14 MeV neutrons at the Frascati Neutron Generator (FNG) reference neutron field. The data obtained from the calibration experiment were applied for the analysis of activation foil measurements performed during the implemented JET Deuterium-Deuterium (D-D) campaign. The activation results were compared against thermoluminescence measurements and a satisfactory agreement was observed. The proposed method provides confidence on the use of activation technique for the precise estimation of neutron fluence at fusion devices and enables its successful implementation in the forthcoming JET Deuterium-Tritium (D–T) campaign