Interpretation of Secondary Predicates by L1 and L2 Acquisition of Japanese

This study reports the experimental data dealing with differences of the acquisition sequence of Japanese secondary depictive predicates and affectedness of Japanese verbs between Japanese speaking young children (L1 acquisition) and Mandarin Chinese speaking adults learning Japanese (L2 acquisition). The results support Schwartz and Sprouse’s (1996) and Eubank’s (1996) hypothesis that L2 grammar is derived from learners’ L1 grammar at an early stage of L2 acquisition

One Is Concerned Because One Is A Human Being

I am a nomad. I have not had a place to call home in almost two decades. I wander around the world searching for a place to belong, only to discover the forgotten lives and silenced voices. I have come to realize that to find a home, I need to first create a world in which to belong to. My recent works are investigations of possibilities for another world, a world of compassion, through a critique of our current society. I create as I rediscover the forgotten histories and lives. My work captures my process of remembering and celebrating while simultaneously imagining our capacity to function as philanthropists

A Syntactic Analysis of Clefts with Multiple Foci in English

論文Article

Large outdoor fires and the built environment: summary of kick-off workshop

Presentacions del Workshop celebrat com una part del 11th Asia-Oceania Symposium on Fire Science and Technology (AOSFST) a Taipei, Taiwan.The kickoff workshop of the new permanent working group, sponsored by the International Association for Fire Safety Science (IAFSS), entitled Large Outdoor Fires and the Built Environment was held from 3:00 pm to 4:30 pm on Sunday October 21, 2018. The workshop was held as a part of the 11th Asia-Oceania Symposium on Fire Science and Technology (AOSFST) in Taipei, Taiwan. The working group is co-led by Sara McAllister of the U.S. Forest Service (unable to come to Taiwan), Sayaka Suzuki of National Research Institute of Fire and Disaster, and Samuel L. Manzello of NIST’s Engineering Laboratory. The IAFSS permanent working group consists of three subgroups, with subleaders appointed by Manzello, McAllister, and Suzuki, and these are prioritized into the following topics: Ignition Resistant Communities (IRC – led by Elsa Pastor, UPC, unable to come to Taiwan), Emergency Management and Evacuation (EME, led by Enrico Ronchi, Lund University, unable to come to Taiwan), and Large Outdoor Firefighting (LOFF, led by Raphaele Blanchi, CSIRO). The IRC subgroup is focused on developing the scientific basis for new standard testing methodologies indicative of large outdoor fire exposures, including the development of necessary testing methodologies to characterize wildland fuel treatments adjacent to communities. The EME subgroup is focused on developing the scientific basis for effective emergency management strategies for communities exposed to large outdoor fires. The LOFF subgroup is providing a review of various tactics that are used, as well as the various personal protective equipment (PPE), and suggest pathways for research community engagement, including environmental issues in suppressing these fires. The overall objectives are to bring the full depth of knowledge of the IAFSS community to work on these priority topics. At the kickoff workshop, detailed ideas were presented regarding the planned activities of the working group, especially the large workshop to be held at IAFSS 2020.Peer ReviewedPostprint (published version

大規模データを用いた耳鼻咽頭・頭頸部外科領域の稀少イベントに関する介入後短期アウトカム評価

学位の種別: 論文博士審査委員会委員 : （主査）東京大学教授 田中 栄, 東京大学教授 小林 廉毅, 東京大学准教授 池田 均, 東京大学准教授 星 和人, 東京大学講師 吉田 昌史University of Tokyo(東京大学

Characterization of the chromosomal inversion associated with the Koa mutation in the mouse revealed the cause of skeletal abnormalities

<p>Abstract</p> <p>Background</p> <p>Koala (<it>Koa</it>) is a dominant mutation in mice causing bushy muzzle and pinna, and is associated with a chromosomal inversion on the distal half of chromosome 15. To identify the gene responsible for the <it>Koa </it>phenotypes, we investigated phenotypes of <it>Koa </it>homozygous mice and determined the breakpoints of the inversion with a genetic method using recombination between two different chromosomal inversions.</p> <p>Results</p> <p>Skeletal preparation of <it>Koa </it>homozygotes showed marked deformity of the ribs and a wider skull with extended zygomatic arches, in addition to a general reduction in the lengths of long bones. They also had open eyelids at birth caused by a defect in the extension of eyelid anlagen during the embryonic stages. The proximal and distal breakpoints of the <it>Koa </it>inversion were determined to be 0.8-Mb distal to the <it>Trsps1 </it>gene and to 0.1-Mb distal to the <it>Hoxc4 </it>gene, respectively, as previously reported. The phenotypes of mice with the recombinant inverted chromosomes revealed the localization of the gene responsible the <it>Koa </it>phenotype in the vicinity of the proximal recombinant breakpoint. Expression of the <it>Trsps1 </it>gene in this region was significantly reduced in the <it>Koa </it>homozygous and heterozygous embryos.</p> <p>Conclusion</p> <p>While no gene was disrupted by the chromosomal inversion, an association between the <it>Koa </it>phenotype and the proximal recombinant breakpoint, phenotypic similarities with <it>Trps1</it>-deficient mice or human patients with <it>TRSP1 </it>mutations, and the reduced expression of the <it>Trsps1 </it>gene in <it>Koa </it>mice, indicated that the phenotypes of the <it>Koa </it>mice are caused by the altered expression of the <it>Trps1 </it>gene.</p

EGFR Mutations in NSCLC treated with Afatinib

Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors such as afatinib are used for non-small cell lung cancer (NSCLC) and show varying efficacy depending on EGFR gene mutation. Few studies have examined the relationship between EGFR gene mutations and the adverse events of afatinib in NSCLC. This retrospective study included 32 Japanese patients with NSCLC with EGFR gene mutation who were treated with afatinib between May 2014 and August 2018 at Kagawa University Hospital. Among the 32 Japanese patients with NSCLC treated with afatinib, 19 patients were positive for exon 19 deletion mutation (Del 19) and 13 patients were negative for Del 19. The incidence of grade ≥ 2 skin rash was slightly higher in patients positive for Del 19 (42.1% vs. 7.7%, P = 0.050). No significant differences were detected in other adverse events between the two patient groups. Patients positive for Del 19 also showed significantly longer median progression-free survival (288 vs. 84 days, P = 0.049). Our study indicates a higher incidence of skin rash associated with afatinib treatment in Japanese patients with NSCLC positive for Del 19 compared with patients without Del 19. The Del 19 positive patient group also showed better progression-free survival

Summary of workshop large outdoor fires and the built environment

Large outdoorfires present a risk to the built environment. Wildfires that spread into communities, referred to as Wildland-Urban Interface (WUI)fires, havedestroyed communities throughout the world, and are an emerging problem infire safety science. Other examples are large urbanfires including those that haveoccurred after earthquakes. Research into large outdoorfires, and how to potentially mitigate the loss of structures in suchfires, lags other areas offire safety scienceresearch. At the same time, common characteristics betweenfire spread in WUIfires and urbanfires have not been fully exploited. In this paper, an overview of thelarge outdoorfire risk to the built environment from each region is presented. Critical research needs for this problem in the context offire safety scienceare provided.The present paper seeks to develop the foundation for an international research needs roadmap to reduce the risk of large outdoorfires to the built environment.Peer ReviewedPreprin