Estimated pretreatment hemodynamic prognostic factors of aneurysm recurrence after endovascular embolization.

BACKGROUND:Hemodynamic factors play important roles in aneurysm recurrence after endovascular treatment. OBJECTIVE:Predicting the risk of recurrence by hemodynamic analysis using an untreated aneurysm model is important because such prediction is required before treatment. METHODS:We retrospectively analyzed hemodynamic factors associated with aneurysm recurrence from pretreatment models of five recurrent and five stable posterior communicating artery (Pcom) aneurysms with no significant differences in aneurysm volume, coil packing density, or sizes of the dome, neck, or Pcom. Hemodynamic factors of velocity ratio, flow rate, pressure ratio, and wall shear stress were investigated. RESULTS:Among the hemodynamic factors investigated, velocity ratio and flow rate of the Pcom showed significant differences between the recurrence group and stable group (0.630 ± 0.062 and 0.926 ± 0.051, P= 0.016; 56.4 ± 8.9 and 121.6 ± 6.7, P= 0.008, respectively). CONCLUSIONS:Our results suggest that hemodynamic factors may be associated with aneurysm recurrence among Pcom aneurysms. Velocity and flow rate in the Pcom may be a pretreatment prognostic factor for aneurysm recurrence after endovascular treatment

The Fermi energy in acceptor doped SrTiO3 and BaTiO3

In order to evaluate the presence of space charge layers and the magnitude of band bending at electrode interfaces of mixed ionic-electronic conductors we have evaluated the Fermi energies in the bulk and at interfaces of acceptor-doped SrTiO3, BaTiO3 and (Ba,Sr)TiO3. While the interface Fermi energy can be directly obtained using photoelectron spectroscopy (XPS) if conducting electrode materials are deposited, the determination of the bulk Fermi energy is more challenging due to the high resistivity of the samples. One approach is to use XPS on thin films deposited on conducting samples. In general, we observed a good agreement between upper and lower limits of Fermi energies at thin films surfaces and at interfaces. Surprisingly, the Fermi energy is hardly observed below EF-EVB≈2eV (see Fig. 1), although defect chemistry calculations predict values as low as EF-EVB≈2eV for acceptor doped samples, such as Fe-doped SrTiO3 or Mn-doped BaTiO3.c,d Even at anode interfaces of ionically polarized Fe-doped SrTiO3 single crystals,e at which the oxygen vacancy concentration should be very low, we have not observed lower Fermi energies. Please click Additional Files below to see the full abstract

Visualization and unsupervised clustering of emphysema progression using t-SNE analysis of longitudinal CT images and SNPs

Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death worldwide by 2030. A longitudinal study using CT scans of COPD is useful to assess the changes in structural abnormalities. In this study, we performed visualization and unsupervised clustering of emphysema progression using t-distributed stochastic neighbor embedding (t-SNE) analysis of longitudinal CT images, smoking history, and SNPs. The procedure of this analysis is as follows: (1) automatic segmentation of lung lobes using 3D U-Net, (2) quantitative image analysis of emphysema progression in lung lobes, and (3) visualization and unsupervised clustering of emphysema progression using t-SNE. Nine explanatory variables were used for the clustering: genotypes at two SNPs (rs13180 and rs3923564), smoking history (smoking years, number of cigarettes per day, pack-year), and LAV distribution (LAV size and density in upper lobes, LAV size, and density in lower lobes). The objective variable was emphysema progression which was defined as the annual change in low attenuation volume (LAV%/year) using linear regression. The nine-dimensional space was transformed to two-dimensional space by t-SNE, and divided into three clusters by Gaussian mixture model. This method was applied to 37 smokers with 68.2 pack-years and 97 past smokers with 51.1 pack-years. The results demonstrated that this method could be effective for quantitative assessment of emphysema progression by SNPs, smoking history, and imaging features

Association analysis of SNPs with CT image-based phenotype of emphysema progression in heavy smokers

Chronic obstructive pulmonary disease (COPD) is predicted to become the third leading cause of death worldwide by 2030. Smoking is a well-known risk factor in the development of COPD. Association between COPD genes and smoking have been studied. This paper presents an association analysis of single nucleotide polymorphisms (SNPs) with a CT image-based phenotype of emphysema progression in heavy smokers. The emphysema progression was quantitatively represented by the annual increment of low attenuation volume (LAV) on CT scans for five years. 10 candidate SNPs were selected from 316 SNPs in 125 papers of genetic studies of COPD and lung cancer. The genotypes were determined by real-time polymerase chain reaction (PCR) using deoxyribonucleic acid (DNA) extracted from saliva samples. The association analysis was performed by Fisher's exact test and logistic regression analysis. This method was applied to a dataset with 144 participants (71 smokers, 61 past smokers, and 12 non-smokers). The results showed that the genotypes of rs3923564 and rs13180 SNPs were candidate SNPs associated with the CT image based-emphysema progression

Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers.

Sex hormones and their receptors play critical roles in the development and progression of the breast and prostate cancers. Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT-RNAs), are specifically and abundantly expressed in estrogen receptor (ER)-positive breast cancer and androgen receptor (AR)-positive prostate cancer cell lines. SHOT-RNAs are not abundantly present in ER(-) breast cancer, AR(-) prostate cancer, or other examined cancer cell lines from other tissues. ER-dependent accumulation of SHOT-RNAs is not limited to a cell culture system, but it also occurs in luminal-type breast cancer patient tissues. SHOT-RNAs are produced from aminoacylated mature tRNAs by angiogenin-mediated anticodon cleavage, which is promoted by sex hormones and their receptors. Resultant 5\u27- and 3\u27-SHOT-RNAs, corresponding to 5\u27- and 3\u27-tRNA halves, bear a cyclic phosphate (cP) and an amino acid at the 3\u27-end, respectively. By devising a cP-RNA-seq method that is able to exclusively amplify and sequence cP-containing RNAs, we identified the complete repertoire of 5\u27-SHOT-RNAs. Furthermore, 5\u27-SHOT-RNA, but not 3\u27-SHOT-RNA, has significant functional involvement in cell proliferation. These results have unveiled a novel tRNA-engaged pathway in tumorigenesis of hormone-dependent cancers and implicate SHOT-RNAs as potential candidates for biomarkers and therapeutic targets

Calibration and Performance of the AKARI Far-Infrared Surveyor (FIS) -- Slow-Scan Observation Mode for Point Sources

We present the characterization and calibration of the Slow-Scan observation mode of the Far-Infrared Surveyor (FIS) onboard the AKARI satellite. The FIS, one of the two focal-plane instruments on AKARI, has four photometric bands between 50--180 um with two types of Ge:Ga array detectors. In addition to the All-Sky Survey, FIS has also taken detailed far-infrared images of selected targets by using the Slow-Scan mode. The sensitivity of the Slow-Scan mode is one to two orders of magnitude better than that of the All-Sky Survey, because the exposure time on a targeted source is much longer. The point spread functions (PSFs) were obtained by observing several bright point-like objects such as asteroids, stars, and galaxies. The derived full widths at the half maximum (FWHMs) are ~30'' for the two shorter wavelength bands and ~40'' for the two longer wavelength bands, being consistent with those expected by the optical simulation, although a certain amount of excess is seen in the tails of the PSFs. The flux calibration has been performed by the observations of well-established photometric calibration standards (asteroids and stars) in a wide range of fluxes. After establishing the method of aperture photometry, the photometric accuracy for point-sources is better than +-15% in all of the bands expect for the longest wavelength.Comment: 25 pages, 7 figures, accepted publication in PAS