Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Hydrological Process Simulation of Inland River Watershed: A Case Study of the Heihe River Basin with Multiple Hydrological Models

Simulating the hydrological processes of an inland river basin can help provide the scientific guidance to the policies of water allocation among different subbasins and water resource management groups within the subbasins. However, it is difficult to simulate the hydrological processes of an inland river basin with hydrological models due to the non-consistent hydrological characteristics of the entire basin. This study presents a solution to this problem with a case study about the hydrological process simulation in an inland river basin in China, Heihe River basin. It is divided into the upper, middle, and lower reaches based on the distinctive hydrological characteristics in the Heihe River basin, and three hydrological models are selected, applied, and tested to simulate the hydrological cycling processes for each reach. The upper reach is the contributing area with the complex runoff generation processes, therefore, the hydrological informatic modeling system (HIMS) is utilized due to its combined runoff generation mechanisms. The middle reach has strong impacts of intensive human activities on the interactions of surface and subsurface flows, so a conceptual water balance model is applied to simulate the water balance process. For the lower reach, as the dissipative area with groundwater dominating the hydrological process, a groundwater modeling system with the embedment of MODFLOW model is applied to simulate the groundwater dynamics. Statistical parameters and water balance analysis prove that the three models have excellent performances in simulating the hydrological process of the three reaches. Therefore, it is an effective way to simulate the hydrological process of inland river basin with multiple hydrological models according to the characteristics of each subbasin

Changes in Different Classes of Precipitation and the Impacts on Sediment Yield in the Hekouzhen-Longmen Region of the Yellow River Basin, China

The sediment yield of the Yellow River Basin has obviously decreased since the 1980s, and the impacts of precipitation on sediment yield changes have become increasingly important with the global climate change. The spatial and temporal variations in annual precipitation and different classes of precipitation in the Hekouzhen-Longmen region (HLR) in the middle reaches of the Yellow River Basin were investigated using data collected from 301 rainfall stations from 1966 to 2016. The impacts of precipitation variation on sediment yield were evaluated, and the hydrological modeling method was used to quantitatively assess the attribution of precipitation and other factors to sediment yield changes in the HLR. The results show that the annual precipitation and P10 increased from the northwest to the southeast of the HLR, suggesting it was drier in the northwest region of the HLR. P25 and P50 were mainly concentrated in the northwestern and southwestern parts of the HLR, reflecting that heavy rain was more likely to occur in these regions of the HLR. All of the annual precipitation and different classes of precipitation had no significant changing trends from 1966 to 2016, and the relationship between rainfall and sediment yield obviously changed in 2006. Compared with the average annual mean values from 1966 to 2016, both the annual precipitation and the different classes of precipitation were higher in the HLR during 2007–2016. The sediment yield decrease during 1990–1999 was mainly influenced by precipitation, while other factors were the main driving factor for the sediment yield decrease in the periods of 1980–1989, 2000–2009, and 2010–2016, and other factors have become the dominant driving factors of the sediment yield change in the HLR since 2000