2 research outputs found
Rearranged Benzophenones and Prenylated Xanthones from <i>Garcinia propinqua</i> Twigs
The first phytochemical investigation of <i>Garcinia
propinqua</i> has led to the isolation and identification of
three new compounds,
including two rearranged benzophenones, doitunggarcinones A (<b>1</b>) and B (<b>2</b>), and a xanthone, doitunggarcinone
C (<b>3</b>), together with seven known compounds (<b>4</b>–<b>10</b>). The structures of <b>1</b>–<b>3</b> were elucidated on the basis of spectroscopic methods, including
UV, IR, NMR, and MS. The antibacterial activity of the 10 isolates
was evaluated against <i>Escherichia coli</i> TISTR 780, <i>Salmonella typhimurium</i> TISTR 292, <i>Staphylococcus
aureus</i> TISTR 1466, and methicillin-resistant <i>Staphylococcus
aureus</i> (MRSA) SK1
Bioactive Carbazole Alkaloids from <i>Clausena wallichii</i> Roots
Four new carbazole alkaloids, clausenawallines C–F
(<b>1</b>–<b>4</b>), along with 18 known compounds
(<b>5</b>–<b>22</b>) were isolated from the roots
of <i>Clausena wallichii</i>. Compounds <b>3</b>, <b>9</b>, and <b>22</b> exhibited significant antibacterial
activity
against methicillin-resistant <i>Staphylococcus aureus</i> SK1 (MRSA SK1) and <i>Staph. aureus</i> TISTR 1466 with
MIC values in the range 4–16 μg/mL, whereas compound <b>4</b> showed the highest cytotoxicity against oral cavity cancer
(KB) and small-cell lung cancer (NCI-H187) with IC<sub>50</sub> values
of 10.2 and 4.5 μM, respectively