Bioactive Carbazole Alkaloids from <i>Clausena wallichii</i> Roots

Abstract

Four new carbazole alkaloids, clausenawallines C–F (<b>1</b>–<b>4</b>), along with 18 known compounds (<b>5</b>–<b>22</b>) were isolated from the roots of <i>Clausena wallichii</i>. Compounds <b>3</b>, <b>9</b>, and <b>22</b> exhibited significant antibacterial activity against methicillin-resistant <i>Staphylococcus aureus</i> SK1 (MRSA SK1) and <i>Staph. aureus</i> TISTR 1466 with MIC values in the range 4–16 μg/mL, whereas compound <b>4</b> showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC₅₀ values of 10.2 and 4.5 μM, respectively