Relative risks of stroke associated with menopausal symptoms.

<p>Basic model: adjusted for age and non-established cardiovascular risk factors; Fully-adjusted model, adjusted for established cardiovascular risk factors and potential mediators. VMS, vasomotor symptoms; vasomotor symptoms include hot flashes and /or night sweats; All, includes vasomotor and other menopausal symptoms; Other, includes menopausal symptoms such as depression, insomnia, and panic attacks. Assessment of heterogeneity for basic model: All symptoms, X² ₂ = 3.26, I² = 39%, 0 to 81%; <i>P</i> = 0.196; other symptoms, X² ₁ = 2.03, I² = 51%, 0 to 87%; <i>P</i> = 0.154. Assessment of heterogeneity for full-adjusted model: All symptoms, X² ₂ = 1.86, I² = 0%, 0 to 90%; <i>P</i> = 0.395; other symptoms, X² ₁ = 1.72, I² = 42%; <i>P</i> = 0.189.</p

Assessment of study quality through the Newcastle-Ottawa Scale.

<p>Assessment of study quality through the Newcastle-Ottawa Scale.</p

Relative risks of coronary heart disease associated with menopausal symptoms.

<p>Basic model: adjusted for age and non-established cardiovascular risk factors; Fully-adjusted model, adjusted for established cardiovascular risk factors and potential mediators. VMS, vasomotor symptoms; vasomotor symptoms include hot flashes and /or night sweats; All, includes vasomotor and other menopausal symptoms; Other, includes menopausal symptoms such as depression, insomnia, and panic attacks. Assessment of heterogeneity for basic model: All symptoms, X2 7 = 81.22, I2 = 91%, 85 to 95%; P < 0.001; vasomotor symptoms, X2 1 = 1.55, I2 = 35%; P = 0.213; other symptoms, X2 5 = 63.48, I2 = 92%, 86 to 96%; P < 0.001. Assessment of heterogeneity for fully-adjusted model: All symptoms, X2 6 = 29.20, I2 = 79%, 58 to 90%; P < 0.001; vasomotor symptoms, X2 1 = 0.09, I2 = 0%; P = 0.762; other symptoms, X2 4 = 22.63, I2 = 82%, 59 to 92%; P < 0.001.</p

Flow diagram of studies included in the current review.

<p>Flow diagram of studies included in the current review.</p

Relative risks of cardiovascular disease associated with menopausal symptoms.

<p>Basic model: adjusted for age and non-established cardiovascular risk factors; Fully-adjusted model, adjusted for established cardiovascular risk factors and potential mediators. VMS, vasomotor symptoms; vasomotor symptoms include hot flashes and /or night sweats; All, includes vasomotor and other menopausal symptoms; Other, includes menopausal symptoms such as depression, insomnia, and panic attacks. Assessment of heterogeneity for basic model: All symptoms, X2 3 = 9.95, I2 = 70%, 13 to 90%; P = 0.019; other symptoms, X2 2 = 7.05, I2 = 72%, 4 to 92%; P = 0.045. Assessment of heterogeneity for full-adjusted model: All symptoms, X2 3 = 8.68, I2 = 65%, 0 to 88%; P = 0.034; other symptoms, X2 2 = 8.67, I2 = 77%, 25 to 93%; P = 0.013.</p

General characteristics of prospective studies of cardiovascular disease outcomes included in review.

<p>General characteristics of prospective studies of cardiovascular disease outcomes included in review.</p