<p>Basic model: adjusted for age and non-established cardiovascular risk factors; Fully-adjusted model, adjusted for established cardiovascular risk factors and potential mediators. VMS, vasomotor symptoms; vasomotor symptoms include hot flashes and /or night sweats; All, includes vasomotor and other menopausal symptoms; Other, includes menopausal symptoms such as depression, insomnia, and panic attacks. Assessment of heterogeneity for basic model: All symptoms, X2 7 = 81.22, I2 = 91%, 85 to 95%; P < 0.001; vasomotor symptoms, X2 1 = 1.55, I2 = 35%; P = 0.213; other symptoms, X2 5 = 63.48, I2 = 92%, 86 to 96%; P < 0.001. Assessment of heterogeneity for fully-adjusted model: All symptoms, X2 6 = 29.20, I2 = 79%, 58 to 90%; P < 0.001; vasomotor symptoms, X2 1 = 0.09, I2 = 0%; P = 0.762; other symptoms, X2 4 = 22.63, I2 = 82%, 59 to 92%; P < 0.001.</p
