Growth of Neurospora

Growth of Neurospor

Using formative research to develop a hospital-based perinatal public health intervention in the US: The Thirty Million Words Initiative Newborn Parent Education Curriculum

Parents and caregivers do not exist in a vacuum, and with regard to crafting impactful interventions, it is increasingly being recognized that there are no one-size-fits-all approaches to behavior change. Implementing research to practice is a complex endeavor and requires the adaptation of basic research findings to different cultural and environmental contexts of intended beneficiaries (Sepinwall, 2002; Weisner & Hay, 2014). The practice of formative research allows for the systematic assessment of diverse implementation contexts and provides insights into responsive adaptations of content and delivery. In this study, we detail the use of formative testing to inform the development of a curriculum designed to support the Universal Newborn Hearing Screening (UNHS): the Thirty Million Words Initiative Newborn (TMW-Newborn) Parent Education Curriculum provides caregivers of newborns with information on the UNHS and illustrates the importance of identifying if a newborn is deaf or hard of hearing (D/HH) to ensure that caregivers learn how to promote early language development. The information provided could potentially reduce lost-to-follow up (LFU) rates for newborns who may be D/HH. Using qualitative methods, we collected and responded to feedback obtained from caregivers of newborns and were able to gear content, messaging and delivery of the intervention to stakeholder needs. A subsample of participants also completed a knowledge survey testing their understanding of intervention content prior to receiving the intervention, as well as the day after. The results showed that participant scores increased significantly post-intervention

Conformal Tightness of Holographic Scaling in Black Hole Thermodynamics

The near-horizon conformal symmetry of nonextremal black holes is shown to be a mandatory ingredient for the holographic scaling of the scalar-field contribution to the black hole entropy. This conformal tightness is revealed by semiclassical first-principle scaling arguments through an analysis of the multiplicative factors in the entropy due to the radial and angular degrees of freedom associated with a scalar field. Specifically, the conformal SO(2,1) invariance of the radial degree of freedom conspires with the area proportionality of the angular momentum sums to yield a robust holographic outcome.Comment: 23 pages, 1 figure. v2 & v3: expanded explanations and proofs, references added, typos corrected; v3: published versio

Casimir Energy of the Universe and New Regularization of Higher Dimensional Quantum Field Theories

Casimir energy is calculated for the 5D electromagnetism and 5D scalar theory in the {\it warped} geometry. It is compared with the flat case. A new regularization, called {\it sphere lattice regularization}, is taken. In the integration over the 5D space, we introduce two boundary curves (IR-surface and UV-surface) based on the {\it minimal area principle}. It is a {\it direct} realization of the geometrical approach to the {\it renormalization group}. The regularized configuration is {\it closed-string like}. We do {\it not} take the KK-expansion approach. Instead, the position/momentum propagator is exploited, combined with the {\it heat-kernel method}. All expressions are closed-form (not KK-expanded form). The {\it generalized} P/M propagators are introduced. We numerically evaluate \La(4D UV-cutoff), \om(5D bulk curvature, warp parameter) and $T$(extra space IR parameter) dependence of the Casimir energy. We present two {\it new ideas} in order to define the 5D QFT: 1) the summation (integral) region over the 5D space is {\it restricted} by two minimal surfaces (IR-surface, UV-surface) ; or 2) we introduce a {\it weight function} and require the dominant contribution, in the summation, is given by the {\it minimal surface}. Based on these, 5D Casimir energy is {\it finitely} obtained after the {\it proper renormalization procedure.} The {\it warp parameter} \om suffers from the {\it renormalization effect}. The IR parameter $T$ does not. We examine the meaning of the weight function and finally reach a {\it new definition} of the Casimir energy where {\it the 4D momenta(or coordinates) are quantized} with the extra coordinate as the Euclidean time (inverse temperature). We examine the cosmological constant problem and present an answer at the end. Dirac's large number naturally appears.Comment: 13 paes, 8 figures, proceedings of 1st Mediterranean Conf. on CQ

Collaborative design of accessible information with people with aphasia

Background: People with aphasia report preferences for specially formatted health information materials, but there is little evidence that modified materials result in improved comprehension. Potential explanations for this include language included not taking account of aphasic processing difficulties, topics unrelated to aphasia, lack of clarity regarding the use of images, and the lack of end-user involvement in the design. Additionally, no definitive criteria for production of accessible information have been identified. Aims: The first aim of this study was to collaborate with people with aphasia in an iterative design process to develop and finalise accessible information materials. The second aim was to identify definitive criteria for use in the future production of information materials for people with aphasia. Methods and procedure: Prototype materials were developed for the study, were based on criteria identified from the existing research into aphasia-accessible information, and on the evidence base concerning language processing in aphasia. Fourteen people with aphasia took part in two rounds of consensus group meetings and viewed information about aphasia presented within the prototype materials. Consensus points were identified within the groups through discussion and through ratings using Likert scales. The set of consensus points and ratings were adapted into criteria for graphic designers to incorporate into subsequent designs of the materials, in order to generate a final version, and related criteria. Outcomes and results: The group discussions and the ratings of materials led to the identification of an agreed layout within which to present information, and specific criteria for the following: information consisting of one proposition expressed via everyday words and canonical syntactic forms; one or two images relating directly to keywords; sans serif typography with keyword emphasis. Individual preferences with regard to image types were identified. Novel criteria were identified in the study, relating to layout, language, images and typography. These were added to the original set of criteria to form definitive criteria for use in the development of accessible aphasia materials. Conclusions: This study successfully involved people with aphasia in the design process to produce novel materials, and related design criteria. The resulting materials and criteria differ from those previously proposed, by reflecting directly people with aphasia’s views and preferences, and by incorporating language and images suitable for people with aphasia, based on the existing research evidence and the outcomes of this study. The materials and criteria have the potential to improve people with aphasia’s understanding of health information

Maternal microchimerism in the livers of patients with Biliary atresia

BACKGROUND: Biliary atresia (BA) is a neonatal cholestatic disease of unknown etiology. It is the leading cause of liver transplantation in children. Many similarities exist between BA and graft versus host disease suggesting engraftment of maternal cells during gestation could result in immune responses that lead to BA. The aim of this study was to determine the presence and extent of maternal microchimerism (MM) in the livers of infants with BA. METHODS: Using fluorescent in situ hybridization (FISH), 11 male BA & 4 male neonatal hepatitis (NH) livers, which served as controls, were analyzed for X and Y-chromosomes. To further investigate MM in BA, 3 patients with BA, and their mothers, were HLA typed. Using immunohistochemical stains, the BA livers were examined for MM. Four additional BA livers underwent analysis by polymerase chain reaction (PCR) for evidence of MM. RESULTS: By FISH, 8 BA and 2 NH livers were interpretable. Seven of eight BA specimens showed evidence of MM. The number of maternal cells ranged from 2–4 maternal cells per biopsy slide. Neither NH specimen showed evidence of MM. In addition, immunohistochemical stains confirmed evidence of MM. Using PCR, a range of 1–142 copies of maternal DNA per 25,000 copies of patients DNA was found. CONCLUSIONS: Maternal microchimerism is present in the livers of patients with BA and may contribute to the pathogenesis of BA