GC-380 DineNGo Application

This project aims to upgrade the DineNGo application, a software tool for restaurant management, with new features specified by the client, The Driven Software Solutions. The upgraded version includes enhancements to users\u27 roles, such as implementing Role-Based Access Control (RBAC), and adding a payment required feature before order placement. Additionally, the new features aim to improve payment processing, reduce trips back and forth to the POS terminal, and provide a secure payment experience for customers. This document provides an overview of the project\u27s scope, objectives, and system overview, along with the operational policies and constraints

EVALUATION OF WOUND HEALING ACTIVITY WITH A NEW FORMULATION OF DRY MANGIFERA INDICA AND HONEY USING SWISS ALBINO MICE

ABSTRACTObjective: A new formulation was made with dry M. indica power in combination with honey to understand the activity of wound healing on Swissalbino mice.Methods: Initially, animals were grouped into four groups, and a wound of 150 mm was created. All the groups were taken for the study, and woundcontraction was studied on different days. The control group was treated with saline, Vitamin E was used as standard of the care, and other groupswere treated with 200 mg/kg and 500 mg/kg of the new formulation.Results: Wound healing started after 4th2 day in the standard treated group, and the other formulation treated groups also started wound contractionfrom 2nd day onward, whereas control did not show any wound contraction after 2 day. However, significant wound contraction observed aftertreatment with 500 mg of formulation on the 10thnd day, and this cannot be compared with the standard group on the 12 day. Even good woundcontraction observed with 200 mg/kg of the formulation which is similar to that of standard treated groups. The control group showed woundcontraction of about 34.72 mm2, whereas the standard group showed 9.58 mm and the formulation-treated groups 200 mg/kg and 500 mg/kgshowed 15.39 mm2 and 8.48 mm2.2Conclusion: This observation showed that a good wound contraction observed with a new formulation.Keywords: Mangifera indica, Honey, Wound healing, Wound contraction, Swiss albino mice.t

Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer

Metabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of function of the mitochondrial tricarboxylic acid (TCA) cycle enzyme subunit succinate dehydrogenase B (SDHB) results in various forms of cancer typified by pheochromocytoma (PC). Here we delineate a signaling cascade where the loss of SDHB induces the Warburg effect, triggers dysregulation of [Ca2+]i, and aberrantly activates calpain and protein kinase Cdk5, through conversion of its cofactor from p35 to p25. Consequently, aberrant Cdk5 initiates a phospho-signaling cascade where GSK3 inhibition inactivates energy sensing by AMP kinase through dephosphorylation of the AMP kinase γ subunit, PRKAG2. Overexpression of p25-GFP in mouse adrenal chromaffin cells also elicits this phosphorylation signaling and causes PC. A potent Cdk5 inhibitor, MRT3-007, reverses this phospho-cascade, invoking a senescence-like phenotype. This therapeutic approach halted tumor progression in vivo. Thus, we reveal an important mechanistic feature of metabolic sensing and demonstrate that its dysregulation underlies tumor progression in PC and likely other cancers

Collective photonic response of high refractive index dielectric metasurfaces

Sub-wavelength periodic nanostructures give rise to interesting optical phenomena like efective refractive index, perfect absorption, cloaking, etc. However, such structures are usually metallic which results in high dissipative losses and limitations for usetherefore, dielectric nanostructures are increasingly considered as a strong alternative to plasmonic (metallic) materials. In this work, we show light-matter interaction in a high refractive index dielectric metasurface consisting of an array of cubic dielectric nano-structures made of very high refractive index material, Te in air, using computer modelling. We observe a distinct band-like structure in both transmission and refection spectra resulting from the near-feld coupling of the feld modes from neighboring dielectric structures followed by a sharp peak in the transmission at higher frequencies. From the spatial distribution of the electric and magnetic felds and a detailed multipole analysis in both spherical harmonics and Cartesian components, the dominant resonant modes are identifed to be electric and magnetic dipoles. Specifcally at lower frequency (60 THz) a novel anapole-like state characterized by strong-suppression in refection and absorption is observed, reported very recently as ‘lattice-invisibility’ state. Diferently, at higher frequency (62 THz), strong absorption and near-zero far feld scattering are observed, which combined with the feld profles and the multipole analysis of the near-felds indicate the excitation of an anapole. Notably the observed novel modes occur in the simple geometry of dielectric cubes and are a result of collective response of the metasurfaces. Periodicity of the cubic metasurface is shown as the signifcant material tuning parameter, allowing for the near-feld and far-feld coupling efects of anapole metasurface. More generally, our work is a contribution towards developing far-fetching applications based on metamaterials such as integrated devices and waveguides consisting of non-radiating modes

Multi-frequency Variability Study of Flat-Spectrum Radio Quasar PKS 0346-27

We have presented a multiwavelength temporal and spectral study of the Blazar PKS 0346-27 between the time period 2019 January-2021 December (MJD 58484-59575). We analysed the data collected by Fermi-LAT (gamma-rays), Swift-XRT (x-rays) and Swift-UVOT (ultra-violet). Flaring episodes are identified by analysing the gamma-ray lightcurve. Flares are fitted using polynomial fit. We have found rapid variability on time scales of hours during brightest flaring activity, which implies that the emission region is very compact. The broadband emission mechanism was studied by modelling the simultaneous multi waveband Spectral Energy Distributions (SED) using leptonic emission mechanism. We found that the optical-UV and X-ray data can be explained by the synchrotron emission. However, the high energy peak is best fitted with external Compton of disk photon rather than the BLR or DT. Our modeling also suggest that the flare 1 and flare 5 have more jet power than flare 2 and 3 which can be caused by different processes. It also suggest that all the flares are produced in different situation. An auto correlation of gamma-ray lightcure was done and concluded the possibility of the source being gravitationally lensed. We have also produced the power spectral density for this source and a powerlaw seems to produce the best fit with slope 2.15+/-0.87 suggesting variability in this source is dominated by stochastic process. This source could be a promising target for upcoming CTA for its harder spectrum at lower energies (tens of GeV)

External validation of four Pancreatic Fistula Risk Score models in the Deep South US: Do racial disparities affect pancreatic fistula prediction?

Fistula Risk Score (FRS) models often lack adequate discrimination for clinically relevant postoperative pancreatic fistula (CR-POPF) on external validation. We tested four FRS models in the Deep South United States and sought to determine if CR-POPF discrimination was affected by racial disparities. A single-institution retrospective cohort study of patients who underwent pancreatoduodenectomies between 2013 and 2019 was performed. FRS discrimination for CR-POPF was assessed using ROC curves for both the entire patient population, and for Black vs White patients. The Alternative FRS maintains adequate CR-POPF discrimination when considering the patient population as a whole, but inadequately predicts CR-POPF when applied to the Black patient population. The Sun-FRS provides adequate CR-POPF discrimination for Black patients when considering risk grade. Only soft pancreatic gland texture and small duct size were significantly associated with CR-POPF in this patient population. Institutions should assess their preferred FRS model to determine if it provides adequate CR-POPF discrimination among a racially diverse patient population. Further studies are needed to determine how racial disparities influence CR-POPF prediction to better guide postoperative management

Supplemental Material - Resection Versus Observation for Small (≤2 cm) Pancreatic Neuroendocrine Tumors

Supplemental Material for Resection Versus Observation for Small (≤2 cm) Pancreatic Neuroendocrine Tumors by Ahmer Irfan, Frank Gleason, Sushanth Reddy, Martin J Heslin, and J Bart Rose in The American Surgeon</p