Effectiveness of Dietary Interventions in the Treatment of Endometriosis: a Systematic Review

A patients’ increasing interest in dietary modifications as a possible complementary or alternative treatment of endometriosis is observed. Unfortunately, the therapeutic potential of dietary interventions is unclear and to date no guidelines to assist physicians on this topic exist. The aim of this study, therefore, was to systematically review the existing studies on the effect of dietary interventions on endometriosis. An electronic-based search was performed in MEDLINE and COCHRANE. We included human and animal studies that evaluated a dietary intervention on endometriosis-associated symptoms or other health outcomes. Studies were identified and coded using standard criteria, and the risk of bias was assessed with established tools relevant to the study design. We identified nine human and 12 animal studies. Out of the nine human studies, two were randomized controlled trials, two controlled studies, four uncontrolled before-after studies, and one qualitative study. All of them assessed a different dietary intervention, which could be classified in one of the following principle models: supplementation with selected dietary components, exclusion of selected dietary components, and complete diet modification. Most of the studies reported a positive effect on endometriosis; they were however characterized by moderate or high-risk bias possibly due to the challenges of conducting dietary intervention trials. According to the available level of evidence, we suggest an evidence-based clinical approach for physicians to use during consultations with their patients. Further well-designed randomized controlled trials are needed to accurately determine the short-term and long-term effectiveness and safety of different dietary interventions

Radiofrequency Ablation for Adenomyosis.

Adenomyosis is a common benign gynecologic condition characterized by ectopic endometrial glands and stroma in the myometrium causing pain (dysmenorrhea) and abnormal uterine bleeding. New interventional techniques have been introduced over recent years. This study evaluates the treatment success and side effects of radiofrequency ablation. An electronic literature search in the PubMed, Scopus, and ScienceDirect databases was carried out on the outcomes of pain reduction and, secondarily, on abnormal uterine bleeding, reintervention, reproductive outcome, imaging outcome, and complications. There was a mean decrease in dysmenorrhea pain scores by -63.4 ± 9.0% at 12 months. Data on other outcome parameters were sparse. No major complications were reported. Radiofrequency ablation represents a promising minimally invasive and organ-preserving treatment in patients with symptomatic adenomyosis. It is associated with clinically meaningful improvement of adenomyosis-related pain in the short term

After the interaction: an efficiently star-forming molecular disk in NGC 5195

We present new molecular gas maps of NGC 5195 (alternatively known as M51b) from the Combined Array for Research in Millimeter Astronomy, including ^(12)CO(1–0), ^(13)CO(1–0), CN(1_(0,2)–0_(0,1)), CS(2–1), and 3 mm continuum. We also detected HCN(1–0) and HCO^+(1–0) using the Onsala Space Observatory. NGC 5195 has a ^(12)CO/^(13)CO ratio (R_(12/13) = 11.4 ± 0.5) consistent with normal star-forming galaxies. The CN(1–0) intensity is higher than is seen in an average star-forming galaxy, possibly enhanced in the diffuse gas in photo-dissociation regions. Stellar template fitting of the nuclear spectrum of NGC 5195 shows two stellar populations: an 80% mass fraction of old (≳10 Gyr) and a 20% mass fraction of intermediate-aged (≈1 Gyr) stellar populations. This provides a constraint on the timescale over which NGC 5195 experienced enhanced star formation during its interaction with M51a. The average molecular gas depletion timescale in NGC 5195 is τ_(dep) = 3.08 Gyr, a factor of ≈2 larger than the depletion timescales in nearby star-forming galaxies, but consistent with the depletion seen in CO-detected early-type galaxies. While radio continuum emission at centimeter and millimeter wavelengths is present in the vicinity of the nucleus of NGC 5195, we find it is most likely associated with nuclear star formation rather than radio-loud AGN activity. Thus, despite having a substantial interaction with M51a ~1/2 Gyr ago, the molecular gas in NGC 5195 has resettled and is currently forming stars at an efficiency consistent with settled early-type galaxies

Warm H2_2 as a probe of massive accretion and feedback through shocks and turbulence across cosmic time

Galaxy formation depends on a complex interplay between gravitational collapse, gas accretion, merging, and feedback processes. Yet, after many decades of investigation, these concepts are poorly understood. This paper presents the argument that warm H$_2$ can be used as a tool to unlock some of these mysteries. Turbulence, shocks and outflows, driven by star formation, AGN activity or inflows, may prevent the rapid buildup of star formation in galaxies. Central to our understanding of how gas is converted into stars is the process by which gas can dissipate its mechanical energy through turbulence and shocks in order to cool. H$_2$ lines provide direct quantitative measurements of kinetic energy dissipation in molecular gas in galaxies throughout the Universe. Based on the detection of very powerful H$_2$ lines from z = 2 galaxies and proto-clusters at the detection limits of {\it Spitzer}, we are confident that future far-IR and UV H$_2$ observations will provide a wealth of new information and insight into galaxy evolution to high-z. Finally, at the very earliest epoch of star and galaxy formation, warm H$_2$ may also provide a unique glimpse of molecular gas collapse at 7 $<$ z $<$ 12 in massive dark matter (DM) halos on their way to forming the very first galaxies. Such measurements are beyond the reach of existing and planned observatories.Comment: Submitted as a science White Paper to the Astronomy and Astrophysics Astro 2020 Decadal Survey call issued by the National Academies of Sciences, Engineering and Medicine (March 11 2019

The genomic origins of the world’s first farmers

The precise genetic origins of the first Neolithic farming populations in Europe and Southwest Asia, as well as the processes and the timing of their differentiation, remain largely unknown. Demogenomic modeling of high-quality ancient genomes reveals that the early farmers of Anatolia and Europe emerged from a multiphase mixing of a Southwest Asian population with a strongly bottlenecked western hunter-gatherer population after the last glacial maximum. Moreover, the ancestors of the first farmers of Europe and Anatolia went through a period of extreme genetic drift during their westward range expansion, contributing highly to their genetic distinctiveness. This modeling elucidates the demographic processes at the root of the Neolithic transition and leads to a spatial interpretation of the population history of Southwest Asia and Europe during the late Pleistocene and early Holocene.Open access articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Warm H₂ as a probe of massive accretion and feedback through shocks and turbulence across cosmic time

Galaxy formation depends on a complex interplay between gravitational collapse, gas accretion, merging, and feedback processes. Yet, after many decades of investigation, these concepts are poorly understood. This paper presents the argument that warm H₂ can be used as a tool to unlock some of these mysteries. Turbulence, shocks and outflows, driven by star formation, AGN activity or inflows, may prevent the rapid buildup of star formation in galaxies. Central to our understanding of how gas is converted into stars is the process by which gas can dissipate its mechanical energy through turbulence and shocks in order to cool. H₂ lines provide direct quantitative measurements of kinetic energy dissipation in molecular gas in galaxies throughout the Universe. Based on the detection of very powerful H₂ lines from z = 2 galaxies and proto-clusters at the detection limits of Spitzer, we are confident that future far-IR and UV H₂ observations will provide a wealth of new information and insight into galaxy evolution to high-z. Finally, at the very earliest epoch of star and galaxy formation, warm H₂ may also provide a unique glimpse of molecular gas collapse at 7 < z < 12 in massive dark matter (DM) halos on their way to forming the very first galaxies. Such measurements are beyond the reach of existing and planned observatories

Warm H_2 as a probe of massive accretion and feedback through shocks and turbulence across cosmic time

Galaxy formation depends on a complex interplay between gravitational collapse, gas accretion, merging, and feedback processes. Yet, after many decades of investigation, these concepts are poorly understood. This paper presents the argument that warm H_2 can be used as a tool to unlock some of these mysteries. Turbulence, shocks and outflows, driven by star formation, AGN activity or inflows, may prevent the rapid buildup of star formation in galaxies. Central to our understanding of how gas is converted into stars is the process by which gas can dissipate its mechanical energy through turbulence and shocks in order to cool. H_2 lines provide direct quantitative measurements of kinetic energy dissipation in molecular gas in galaxies throughout the Universe. Based on the detection of very powerful H_2 lines from z = 2 galaxies and proto-clusters at the detection limits of Spitzer, we are confident that future far-IR and UV H_2 observations will provide a wealth of new information and insight into galaxy evolution to high-z. Finally, at the very earliest epoch of star and galaxy formation, warm H_2 may also provide a unique glimpse of molecular gas collapse at 7 < z < 12 in massive dark matter (DM) halos on their way to forming the very first galaxies. Such measurements are beyond the reach of existing and planned observatories