Bone eQTL data (R/qtl format)

Residual bone and fecundity phenotypes (adjusted for body weight), preprocessed gene expression data and genotypes of the 127 individuals of the bone eQTL study in R/qtl csv input format

Comb eQTL data (R/qtl format)

Residual comb masses, preprocessed gene expression data and genotypes of the 39 individuals of the comb eQTL study in R/qtl csv input format

Bone microarray data (raw and RMA preprocessed)

Microarray data for the 127 individual bone samples. This files contains the raw as well as RMA preprocessed gene expression values, and design files for the custom NimbleGen gene expression chip used

RJF x OS bone phenotypes (QTL express format)

Bone phenotypes (residual values after adjusting for body weight) from the Red Junglefowl x Obese strain White Leghorn intercross in QTL Express format

RJF x OS genetic map (QTL Express format)

Genetic map file for the Red Junglefowl x Obese strain White Leghorn intercross in QTL Express format

RJF x OS genotypes (QTL Express format)

Genotype data from the Red Jungefowl x Obese strain White Leghorn intercross in QTL Express format

Chromosome 3 QTL peaks and confidence intervals (C.I.) from the F₂-L13 (blue line) and F₈-L13 (dark red line) crosses.

<p>In the case of the F₂-L13, the horizontal arrow indicates the 1.8 LOD drop C.I. of the QTL position. The location of the F₈-L13 C.I. has been expanded below the graph to show the location of the two candidate genes and the selective sweep, and the overlap with the F₂-L13 C.I.</p

Additional fecundity and bone morphometric traits correlated with <i>HAO1</i> and <i>BMP2</i> expression in bone samples.

<p>Genotype (QTL) effect and body weight were included in each GLM.</p

General Linear Model results for gene expression and QTL effect on comb mass.

<p>All variables were modelled on comb mass, with the t-statistic and p-value shown for each variable included in each of the models (shown as t-statistic/p-value). ‘-’ is used to indicate where a variable is not included in that particular model. AIC stands for the Akaike Information Criterion of each model. A full description of each model is given in the methods section.</p

Illustration of male and female RJF (lower left) and WL (upper right) comb size.

<p>CT pictures of two diaphyseal bone sections are shown in (A) and (B), with the cortical and medullary bone marked. The correlation between female comb mass relative to body mass and diaphyseal trabecular area shown in (C), and the correlation between relative male comb mass and cortical content is shown in (D).</p